[Changes in the glucocorticoid function of the adrenal cortex in patients with myocardial infarct treated with trioxazine and aminazine]. / Izmeneniia gliukokortikoidnoi funktsii kory nadpochechnikov u bol'nykh infarktom miokarda, lechennykh trioksazinom i aminazinom

A protracted observation over the glucocorticoid function of the adrenal gland in patients with myocardial infarction educed a biphasic nature of changes in the concentration of the plasma and urine corticosteroids in this affection. Most informative are shown to be the evidences of activation of the hypothalamo-hypophysial-adrenal system furnished by the biologically active 11-oxycorticosteroids in the peripheral blood plasma. Psychopharmacological drugs produced a less intensive activation of the glucocorticoid function of the adrenal cortex in the acute period of myocardial infarction and they smooth down a renewed rise in the level of steroid during the subacute period of the disease. Chlorpromazine displays a stronger antistress action than does trioxazine, but the available data justify recommending both these drugs for the treatment of patients with myocardial infarction.