[Obtaining human tumor cell line passaged in tissue culture from strains transplanted into nude mice]. / Poluchenie kletochnykh linii opukholei cheloveka, perevivaemykh v kul'ture tkani, iz shtammov, transplantiruemykh na bestimusnykh myshakh.

Cell lines of uterine cancer and Wilmson tumors have been obtained from human tumor strains serially transplanted to nude mice. These monolayer cell lines were subject to 40 passages in the tissue culture, they possess stable growth parameters and cytological characteristics. It has been shown cytogenetically that the cell lines obtained have human karyotype. Histological description of tumors developing in nude mice upon the administration of those cell lines to them has demonstrated that they correspond to human tumor strains they were derived from.

[Effect of chemotherapy on human tumor heterografts and lymphocytes in athymic mice]. / Vliianie khimioterapii na geterotransplantaty opukholei cheloveka i limfotsity u bestimusnykh myshei.

Sensitivity of human serially transplanted tumours (melanoma, hepatoma, lung, stomach and bladder cancer) to monochemotherapy was studied in nude mice. The following groups of nude mice were examined: intact and those with human xenografts (control and mice treated with alkylating agents). Changes in peripheral blood morphology have been revealed and functional activity of the energetic enzymes (SDH and alpha-GPDH) has been cytochemically discovered.