Multi-domain CT translation by a routable translation network.

Objective.To unify the style of computed tomography (CT) images from multiple sources, we propose a novel multi-domain image translation network to convert CT images from different scan parameters and manufacturers by simply changing a routing vector.Approach.Unlike the existing multi-domain translation techniques, our method is based on a shared encoder and a routable decoder architecture to maximize the expressivity and conditioning power of the network.Main results.Experimental results show that the proposed CT image conversion can minimize the variation of image characteristics caused by imaging parameters, reconstruction algorithms, and hardware designs. Quantitative results and clinical evaluation from radiologists also show that our method can provide accurate translation results.Significance.Quantitative evaluation of CT images from multi-site or longitudinal studies has been a difficult problem due to the image variation depending on CT scan parameters and manufacturers. The proposed method can be utilized to address this for the quantitative analysis of multi-domain CT images.

Free-breathing dynamic T1WI using compressed sensing-golden angle radial sparse parallel imaging for liver MRI in patients with limited breath-holding capability.

PURPOSE: Evaluating the performance of free-breathing dynamic T1-weighted imaging (T1WI) using compressed sensing golden-angle radial sparse parallel imaging (CS-GRASP) in non-cooperative patients compared with a general group. METHOD: This retrospective study included patients who underwent gadoxetic acid-enhanced liver MRI using CS-GRASP at 3 T between March 2018 and October 2019. Patients were divided chronologically, into one of two groups: Group 1, who underwent MRI during the sequence implementation period regardless of breath-hold capability; and Group 2, who underwent MRI from June 2018 due to limited breath-hold capability. Three radiologists evaluated motion and streak artifacts as well as overall image quality on a four-point scale at the precontrast phase, late arterial phase (LAP) and portal venous phase (PVP). Intra-individual comparisons were made between sequences in each group. RESULTS: We identified 102 patients, who were divided into either Group 1 (n = 41) or 2 (n = 61). For the LAP, the former group had higher image quality (3.22 ± 0.65 vs. 2.95 ± 0.61, P < 0.001) and less streak artifact (2.96 ± 0.56 vs. 2.74 ± 0.57, P = 0.001) than the latter. However, there was no significant difference between the two groups regarding either the proportion of patients with acceptable motion artifact, at 92.7% (38/41) for Group 1 vs. 96.7% (59/61) for Group 2, or that of patients with acceptable image quality at 80.5% (33/41) for Group 1 vs. 65.6% (40/61) for Group 2 (P > 0.05). In intra-individual comparisons, portal phase showed the highest image quality than the others in both groups (P < 0.001). CONCLUSIONS: Acceptable image quality for the LAP in non-cooperative patients was provided with a success rate of over 50% via free-breathing T1WI using CS-GRASP.

Body CT and PET/CT detection of extracranial lymphoma in patients with newly diagnosed central nervous system lymphoma.

BACKGROUND: We aimed to investigate the detection rate of body CT or PET/CT for sites of extracranial disease in patients with a new pathological diagnosis of CNS DLBCL and to identify factors associated with sites of extracranial disease. METHODS: An international multicenter cohort study of consecutive immunocompetent patients with a new diagnosis of CNS DLBCL confirmed by brain biopsy who underwent CT and/or PET/CT to evaluate for sites of extracranial disease between 1998 and 2019. The primary outcome was the detection rate of extracranial lymphoma by CT or PET/CT. Subgroup analyses according to age and EBV status were also performed. Logistic regression analyses were performed to determine factors related to sites of extracranial disease. Detection rates of CT and PET/CT were compared. RESULTS: One thousand and forty-three patients were included. The overall detection rate of CT or PET/CT was 2.6% (27/1043). The treatment approach was adjusted in 74% of these patients. Multivariable analysis demonstrated that age >61 years (OR, 3.10; P = .016) and EBV positivity (OR, 3.78; P = .045) were associated with greater odds of extracranial lymphoma. There was no statistically significant difference in detection rate between CT and PET/CT (P = .802). In patients ≤61 years old, the false-referral rates were significantly higher than the detection rates (P < .001). CONCLUSION: Our results showed increased odds of extracranial lymphoma in patients with older age or EBV-positive lymphoma. Treatment was adjusted in a majority of patients diagnosed with extracranial lymphoma, thereby supporting the current guidelines for the use of contrast-enhanced body CT or PET/CT in patients with newly diagnosed CNS DLBCL.

Empyema in a Patient with Schizophrenia Using Clozapine: A Case Report.

Schizophrenia is associated with a high risk of thoracic infections and pneumonia. The use of atypical antipsychotics clozapine may also increase the risk of pulmonary infection. However, psychotic patients are less likely to report physical symptoms, and these dangerous conditions may go undetected. In this case report, we present 47-year-old woman with schizophrenia who had been using clozapine and did not complain of respiratory symptoms. After admission, she was diagnosed with streptococcus intermedius empyema. Although empyema has a high mortality rate, thanks to the timely admission and proper diagnosis, the patient recovered after 3 weeks of medical and surgical treatment.

Diterpenes from the roots of Oryza sativa L. and their inhibition activity on NO production in LPS-stimulated RAW264.7 macrophages.

Two new pimarane diterpenoids, momilactone D (3) and momilactone E (5), along with three known diterpenoids, momilactone A (1), sandaracopimaradien-3-one (2), and oryzalexin A (4) were isolated from Oryza sativa roots. The chemical structures of the compounds were determined by spectroscopic data analysis. The isolated diterpenoids were evaluated for their ability to inhibit NO production and iNOS mRNA and protein expression in LPS-stimulated RAW264.7 macrophages. Compound 4 showed strong inhibition activity on NO production, and compounds 1 and 4 decreased the expression of iNOS mRNA and protein levels.

The development of a new training system for improving equilibrium sense using a virtual bicycle simulator.

In this paper, a new rehabilitation training system was developed to improve equilibrium sense control by combining virtual reality technology with a fixed exercise bicycle. In order to evaluate the effectiveness of the training system, twenty normal healthy adults participated as test subjects in the investigation of the influence of different the parameters on equilibrium sensory control. Several factors including path deviation, cycling time, cycling velocity, center of pressure were evaluated and analyzed quantitatively. Also, we investigated the usefulness of virtual feedback information for weight shift on the improvement of the effect of equilibrium training. After conducting repeated tests, we found improvements not only in of the ability to controlling balance and weight shift but also in the overall cycling capabilities such as cycling speed. Therefore, the new training system utilizing an excise bike and a virtual reality system is found to be effective on the improvement of equilibrium sense, and the technology we have developed seems to have a good prospect in the rehabilitation field.