ABSTRACT
Hyperferremia is shown to affect antioxidant system of the body, oxidation-reduction reactions in the cells seen as shifts in lymphocyte chemiluminescence. Dynamic changes in lymphocyte chemiluminescence reflect the level of hyperferremia.
Subject(s)
Iron/blood , Lymphocytes/metabolism , Antioxidants , Combined Modality Therapy , Deferoxamine/therapeutic use , Dose-Response Relationship, Drug , Ferritins/pharmacology , Free Radicals/blood , Hemochromatosis/blood , Hemochromatosis/therapy , Humans , Iron/pharmacology , Luminescent Measurements , Lymphocyte Activation/drug effects , Lymphocytes/drug effects , Myelodysplastic Syndromes/blood , Myelodysplastic Syndromes/therapy , Plasmapheresis , Transferrin/analysisABSTRACT
Iron metabolism was studied in anemia patients with no iron deficiency. The data obtained have suggested that iron transport to blood-synthesizing cells i disturbed in such patients with normal iron reserves. Basing on the study of iron metabolism and red blood parameters in the patients after the treatment by hypoxic hypoxia it is shown that this method combined with iron therapy can be successfully used for the treatment of this form of iron deficiency anemia.
Subject(s)
Anemia/blood , Iron/blood , Adult , Female , Humans , Iron Deficiencies , Male , Middle AgedABSTRACT
Iron metabolism was studied in patients with refractory anemia. It is shown that continuous transfusions of erythrocytes result in a sharp rise of iron reserves that plays an important role in the development of hemosiderosis. To prevent iron oxidative action it is recommended that the patients should be subjected to therapy with chelating agents and antioxidants simultaneously with transfusions of erythrocytes. A relationship has been noted between blood antioxidant capacity decrease and iron-overloading.
Subject(s)
Anemia, Refractory, with Excess of Blasts/blood , Erythrocytes/metabolism , Iron/blood , Malondialdehyde/blood , Aged , Anemia, Refractory, with Excess of Blasts/therapy , Antioxidants/administration & dosage , Blood Transfusion , Erythrocytes/drug effects , Female , Humans , Male , Malondialdehyde/antagonists & inhibitors , Middle Aged , Oxidation-Reduction/drug effects , Rutin/administration & dosage , Rutin/bloodABSTRACT
A total of 440 clinically normal children aged from 1 month to 1 year, whose parents are indigenes of the Zabaikalye, were investigated to elucidate the influence of the climatic conditions of the Zabaikalye on the erythrocytic system state. It has been found that the total number of red blood cells, the mean volume of cells containing fetal hemoglobin and methemoglobin, and the number of highly-resistant, i.e. young, red cells, are increased in the children of the Zabaikalye, as compared to those living under conditions of a moderate climate. Methemoglobin reductase activity in them is decreased. The data obtained have evidenced that under conditions of chronic hypoxia erythropoiesis in children living in the Zabaikalye is in the state of high tension.