1.
Ann Otol Rhinol Laryngol
; 97(2 Pt 1): 186-91, 1988.
Article
in English
| MEDLINE
| ID: mdl-3355047
ABSTRACT
We studied the fine structure of nasal and middle ear mucosa in 18 patients with chronic otitis media, comparing them with ten age-matched control patients. Electron microscopy revealed no single fundamental defect of cilia in the tissue samples; however, patients with chronic otitis media had a significantly higher incidence of abnormal cilia in the middle ear without correlating abnormalities of nasal cilia. These findings indicated that ciliary anomalies, including deletion of ciliary microtubules, presence of supernumerary tubules, and fusion of cilia, occur as a result of infection or inflammation. Such abnormalities would impair normal mucociliary clearance and exacerbate clinical complications.
Subject(s)
Ear, Middle/ultrastructure , Otitis Media/pathology , Adult , Chronic Disease , Cilia/pathology , Cilia/ultrastructure , Ear, Middle/pathology , Female , Humans , Male , Microscopy, Electron , Middle Aged , Mucous Membrane/pathology , Mucous Membrane/ultrastructure , Nasal Mucosa/ultrastructure
2.
Lab Invest
; 31(1): 6-14, 1974 Jul.
Article
in English
| MEDLINE
| ID: mdl-4367228
Subject(s)
Amino Acids/pharmacology , Glycoproteins/biosynthesis , Golgi Apparatus/drug effects , Nucleosides/pharmacology , Animals , Body Weight , Carbon Radioisotopes , Fucose/metabolism , Glucosamine/metabolism , Golgi Apparatus/enzymology , Golgi Apparatus/metabolism , Inclusion Bodies , Liver/cytology , Male , Membranes/cytology , Microscopy, Electron , Microtubules , Organ Size , Rats , Transferases/metabolism , Tritium
3.
Biochim Biophys Acta
; 320(1): 123-32, 1973 Aug 17.
Article
in English
| MEDLINE
| ID: mdl-4127103