ABSTRACT
The case of a 17-year-old man with Hodgkin's lymphoma who presented with paraneoplastic sensory neuropathy is presented. The patient visited our hospital because of acute progression of dysesthesiae in the bilateral face and extremities. He also developed an ataxic gait due to decreased deep sensation. Post-contrast T1-weighted MRI showed enhancement of both trigeminal nerves and the cauda equina. Cerebrospinal fluid examination was unremarkable. Intravenous immunoglobulin therapy and subsequent steroid pulse therapy did not improve his symptoms. Laboratory data showed an elevated serum soluble interleukin-2 receptor level. His chest X-ray and CT showed enlarged lymph nodes in the mediastinum, and the histopathologic examination of a lymph node biopsy specimen showed classical Hodgkin's lymphoma. He was treated with chemotherapy. His symptoms of neuropathy improved promptly while the lymphoma was being successfully treated, and he was able to walk with a cane. The present case was characterized by paraneoplastic sensory neuropathy as the initial clinical feature in association with Hodgkin's lymphoma. It is necessary to consider a paraneoplastic neurological syndrome even in a young patient with acute/subacute sensory neuropathy. Paraneoplastic sensory neuropathy associated with Hodgkin's lymphoma could be expected to improve with oncotherapy, and examination of the malignancy and early treatment are important.
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Hodgkin Disease/complications , Hodgkin Disease/drug therapy , Mediastinal Neoplasms/complications , Mediastinal Neoplasms/drug therapy , Paraneoplastic Polyneuropathy/drug therapy , Paraneoplastic Polyneuropathy/etiology , Paresthesia/drug therapy , Paresthesia/etiology , Acute Disease , Adolescent , Antineoplastic Combined Chemotherapy Protocols/administration & dosage , Ataxia/drug therapy , Ataxia/etiology , Bleomycin/administration & dosage , Dacarbazine/administration & dosage , Doxorubicin/administration & dosage , Hodgkin Disease/diagnosis , Humans , Magnetic Resonance Imaging , Male , Mediastinal Neoplasms/diagnosis , Tomography, X-Ray Computed , Treatment Outcome , Vinblastine/administration & dosageABSTRACT
Alkoxycarbonylation of arylsulfoniums has been developed with the aid of a catalytic amount of a palladium-Xantphos complex under an atmospheric pressure of CO gas. Various functional groups such as carbonyl, cyano, halo, and sulfonyl groups were well tolerated under the present catalysis. Since aryldimethylsulfoniums were readily prepared from the corresponding aryl methyl sulfides and methyl triflate, one-pot alkoxycarbonylation of aryl methyl sulfides could be accomplished.
ABSTRACT
Mizoroki-Heck-type alkenylation of monoaryldialkylsulfoniums has been accomplished by means of palladium catalysts. Various combinations of monoarylsulfoniums and alkenes were adapted to the present reaction. Because monoaryldimethylsulfoniums were readily prepared from the corresponding aryl methyl sulfides and methyl triflate, one-pot alkenylation of aryl methyl sulfide could also be executed.
