ABSTRACT
Corona virus disease 2019(COVID-19)epidemic has been effectively controlled,but its related complications still cannot be ignored,especially the cardiovascular circulatory system is the active site of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Angiotensin-converting enzyme 2(ACE2)is a type Ⅰ transmembrane glycoprotein that is highly expressed in heart,kidney and testis.Spike protein of SARS-CoV-2 invades host cells by binding to the cell surface receptor ACE2.However,there are still many deficiencies in the clinical application of vaccines and drugs developed based on this target.As a molecular chaperone,cyclophilin A(CypA)promotes protein folding and T cell activation.CD147 is one of the most widely studied CypA receptors,and the interaction of CypA/CD147 plays an important role in the entry of SARS-CoV-2 into host cells.However,there are few reports on the invasion of SARS-CoV-2 into the cardiovascular system through the CypA/CD147 signaling pathway.Based on this,this article summarizes the previous research evidence and the research basis of the research group,and reviews the structure and function of CypA/CD147,the role of CypA/CD147 in cardiovascular disease,and the cardiovascular disease caused by SARS-CoV-2 targeting CypA/CD147 signal pathway,in order to provide reference for the diagnosis and treatment of the COVID-19 complicated with cardiovascular system diseases.
ABSTRACT
MicroRNA is a type of widely distributed endogenous small single-stranded non-coding RNA that regulates important biological processes. It complements the target mRNA sequence, degrades the target mRNA and inhibits protein translation, and plays a regulatory role at the transcription level. Studies have confirmed that microRNAs in circulation are present in various body fluids in a stable form and can be used as biomarkers of disease. miR-144 is highly conservative in structure, exists in the form of miR-144/miR-451 gene cluster in the genome, and participates in the occurrence and development of erythroid differentiation, tumors, and cardiovascular diseases. With the continuous progress of life sciences, miR-144 pathogenic mechanism and role in cardiovascular disease have been gradually revealed. This article gathers the relationship between miR-144 and the pathogenesis of cardiovascular disease and the diagnosis and treatment plan, starting from the relationship between miR-144 and coronary atherosclerotic heart disease, arrhythmia and structural heart disease, combing related research progress, with a view to providing new ideas and methods for the diagnosis and treatment of cardiovascular diseases.