Correlation of degenerative meniscus injury with lower limb alignment:a clinical report of 90 cases / 陆军军医大学学报

Objective To compare the differences in lower limb force line between degenerative medial meniscus injuries and lateral meniscus injuries and investigate their correlation.Methods A total of 90 patients who underwent arthroscopic treatment for meniscal injuries between March 2019 and March 2022 were enrolled in the study.They were 45 males and 45 females,at a median age of 52 years(ranging from 40 to 59 years).Of these patients,47 had medial meniscus injuries,while 43 had lateral meniscus injuries.The hip-knee-ankle(HKA)angle was measured on full-length films,and the differences were compared between the 2 groups.Results There were no significant differences in terms of gender,age,lower limb laterality,body mass index,site of injury,and type of injury between the medial meniscus injury group and the lateral meniscus injury group.Statistical difference was observed in the mean HKA angle,with a value of(177.20±2.46)° in the medial meniscus injury group and of(181.05±3.13)° in the lateral meniscus injury group(P＜0.01).Conclusion There is a significant difference in HKA angle between medial meniscus injury group and the lateral meniscus injury group.A correlation is found between lower limb alignment and degenerative meniscus injury.

Combined application of adductor canal block and local infiltration anesthesia in primary total knee arthroplasty: an updated meta-analysis of randomized controlled trials.

BACKGROUND: Perioperative pain after total knee arthroplasty (TKA) may seriously affect the rapid recovery of patients. The purpose of this study was to assess whether the combined use of adductor canal block (ACB) and local infiltration anesthesia (LIA) can further reduce postoperative pain and improve early functional recovery. MATERIALS AND METHODS: PubMed, Web of Science, EMBASE, and Cochrane Central Register of Controlled Trials were systematically searched for randomized controlled trials (RCTs) comparing ACB + LIA and LIA alone in primary TKA. The primary outcomes were visual analog scale (VAS) scores at rest and walking, morphine consumption, range of motion (ROM) at 24 and 48 h postoperatively and distance walked. The secondary outcomes were the length of stay, the incidence of nausea and vomiting, and the total complications. Subgroup analyses were performed on the VAS at rest and walking, morphine consumption, and distance walked at 24, 48, and 72 h postoperatively. RESULTS: A total of 10 RCTs involving 797 patients were enrolled in this meta-analysis. The results demonstrated that the combined application of ACB + LIA had a lower resting VAS at 24 h postoperatively (p = 0.02) and the walking score at 24 (p = 0.0002) and 48 h (p = 0.02) postoperatively compared with LIA alone. Similarly, the combined ACB + LIA group also had less morphine consumption at 48 h postoperatively (p = 0.0005) and had a higher ROM score at 24 h (p = 0.01) postoperatively compared to the LIA group. There were no statistical differences in length of stay, distance walked, and incidence of nausea and vomiting. CONCLUSION: The current meta-analysis showed that ACB + LIA significantly reduced postoperative walking pain and morphine consumption and promoted rapid recovery in the early postoperative period. There is no statistical difference in the length of stay and ROM after 72 h in the two groups.

Study the toxicology damage of melamine(cyanuric acid) to rats kidney / 重庆医科大学学报

Objective: Study the toxicology damage of melamine(cyanuric acid) to rats' kidney.Methods: Divided the newborn rats and adult rats into high dose group of melamine(NM,M),low dose group of melamine(Nm,m),high dose group of cyanuric acid(NA,A),low dose group of cyanuric acid(Na,a),high dose group of melamine-cyanuric acid(NMA,MA),low dose group of melamine-cyanuric acid(Nma,ma) and normal control group(NN,N).The corresponding dose of melamine(cyanuric acid) was given by oral gavage and lasted two months.Rats were killed at 3 day,15 day and 60 day.The body weight and kidney weight were collected.Renal function was detected and the microscopic and ultra-microscopic renal histology structural changes were observed.Results: The body weight of NMA group and Nma group increased first,and then reduced.The body weight of MA group and ma group reduced gradually.The number of kidney crystal increased with the administration time extension.The electron microscope demonstrated that the tubules which contained stones microvilli reduced or disappeared,granulocyte infiltration and other inflammatory response.The kidney weight/body weight,urea nitrogen,creatinine,uric acid value increased in administration groups.Conclusion: Melamine(cyanuric acid) could produce insoluble crystals in rat kidney and lead to renal dysfunction.The toxicity of melamine(cyanuric acid) was greater in adult rats than in newborn.The number of melamine(cyanuric acid) crystals was positively correlated with dose and time.The toxicity of melamine was greater than cyanuric acid.Melamine(cyanuric acid) mixture toxicity was greater than the monomer.Melamine(cyanuric acid) toxicity had individual differences and brood diffenence.