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NF-kappaB: the inducible factors of HIV-1 transcription and their inhibitors.

Mingyan, Yu; Xinyong, Liu; De Clercq, Erik.

Mini Rev Med Chem ; 9(1): 60-9, 2009 Jan.

Article in English | MEDLINE | ID: mdl-19149660

ABSTRACT

NF-kappaB (NF-kappaB), the transcription factors of HIV-1, play an important role in triggering HIV transcription. The inhibition of NF-kappaB activation and their signaling pathway offers a potential anti-HIV therapy strategy. This review reports the mode of action of NF-kappaB in triggering HIV-1 transcription and the status of the inhibitors.

Subject(s)

Anti-HIV Agents/chemistry , HIV-1/genetics , NF-kappa B/antagonists & inhibitors , Anti-HIV Agents/pharmacology , HIV Infections/drug therapy , HIV-1/drug effects , HIV-1/metabolism , Humans , I-kappa B Proteins/antagonists & inhibitors , I-kappa B Proteins/chemistry , I-kappa B Proteins/metabolism , NF-kappa B/chemistry , NF-kappa B/metabolism , Signal Transduction , Transcription Factors/antagonists & inhibitors , Transcription Factors/chemistry , Transcription Factors/metabolism , Transcription, Genetic

ABSTRACT

Subject(s)

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