Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Obstet Gynecol ; 117(2 Pt 2): 501-503, 2011 Feb.
Article in English | MEDLINE | ID: mdl-21252804

ABSTRACT

BACKGROUND: Sticky platelet syndrome is an autosomal-dominant thrombophilia characterized by platelet hyperaggregability in the presence of adenosine diphosphate or epinephrine. The result clinically can be widespread thromboses, often arterial, in patients without apparent risk factors for thrombotic disease. Limited data exist regarding its role in adverse pregnancy outcomes. CASE: A gravid woman with two previous first-trimester miscarriages presented at 11 weeks of gestation with a deep venous thrombosis. Despite anticoagulation, she developed extensive and progressive arterial and venous thromboses and suffered a fetal demise. A thrombophilia panel was unremarkable, but platelet aggregometry demonstrated hyperactive platelets in the presence of adenosine diphosphate and epinephrine consistent with sticky platelet syndrome. CONCLUSION: Sticky platelet syndrome causes arterial thromboses and may be an underappreciated etiology for adverse pregnancy outcomes.


Subject(s)
Blood Platelet Disorders/complications , Fetal Death/etiology , Pregnancy Trimester, First , Thrombosis/etiology , Abdomen/diagnostic imaging , Anticoagulants/therapeutic use , Blood Platelet Disorders/drug therapy , Dilatation and Curettage , Embolectomy , Female , Humans , Leg/blood supply , Leg/diagnostic imaging , Middle Aged , Platelet Aggregation/drug effects , Pregnancy , Pregnancy Outcome , Radiography, Abdominal , Thrombophilia/complications , Thrombophilia/drug therapy , Thrombosis/drug therapy , Thrombosis/surgery , Ultrasonography , Venous Thrombosis/etiology
SELECTION OF CITATIONS
SEARCH DETAIL
...