[Advantages of topical therapy with polydeoxyribonucleotide in reparative processes after cauterization: experience at a center for early diagnosis of genital neoplasms]. / Vantaggi della terapia topica con polidesossiribonucleotide sui processi riparativi post DTC: esperienza di un centro di diagnosi precoce delle neoplasie genitali.

This paper evaluates the common practice of a topic medical treatment following cautery (or other kinds of microsurgery) of the uterine cervix. Firstly, a controlled clinical trial on 116 patients treated with kanamycin sulphate alternated to polydeoxyribonucleotide vaginal suppositories, and 124 controls has been conducted. Subjective parameters (leukorrhea, bloody discharge, odorous discharge, more than three weeks vaginal discharge, itching, pain, burning) and colposcopy (Schiller test reactivity, squamo-columnar junction location, abnormal transformation zones, vascular striae, deepithelialized areas or frail epithelium) appeared more favorable in the treated group, the colposcopic finding of phlogosis being the only unfavorable finding more frequent among the treated patients. Successively, a controlled double blind clinical trial with kanamycin sulphate alternated to placebo vs PDRN at different dosages has shown an increase in number of epithelial cells in the treated patients and a better stimulation of fibroblasts by higher dosages of active substance. These results show the efficacy of the studied post cautery treatment schedule, and of PDRN in particular.

[Contraception and the desire for pregnancy in the adolescent]. / Contraccezione e desiderio di gravidanza nell'adolescente.

PIP: During a 3 year period, 1982-85, 851 adolescents approached the Voluntary Abortion Service of the L. Mangiagali clinic in Milan. The observations resulting from the clinical and psychological work as well as current international literature on the subject of attitudes towards birth control methods among adolescents are reported. A study by Zelnick and Kantner in 1979 and a study by Furstenberg in 1978 are discussed. Here percentages of nonmarried adolescents between 15-19 with sexual experience are researched concerning their use of contraceptives and frequency of sexual relations according to race and educational level of mother or of tutor. The research by the clinic itself centers on the psychological experiences relative to the possibility of becoming pregnant. In the majority of the pre-voluntary abortion cases, 78% of the adolescents rely on ineffective methods (e.g., coitus interruptus), 14% used the barrier method, 7.7% oral contraceptives and 0.3% IUDs. It is concluded that the adolescent today initiates sexual relations at a much earlier age and confronts the problems of contraceptives without making a decisive and secure choice. One reason is that there does not seem to be suitable institutions where questions relating to sexuality and contraception can be directed. Another reason consists in the conflict between a subconscious desire for pregnancy versus a rational desire to avoid it. During an adolescent's developing years the counsel and support from parents, instructors and institutions of society are important.^ieng