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1.
Dig Liver Dis ; 50(5): 475-481, 2018 May.
Article in English | MEDLINE | ID: mdl-29544764

ABSTRACT

BACKGROUND AND AIMS: There are few prospective data about the use of surveillance colonoscopy and the risk of recurrent neoplasia in first degree relatives (FDRs) of colorectal cancer (CRC) patients. We examined the use and yield of surveillance colonoscopy in a population-based screening program (Trentino, Italy) METHODS: 1252 FDRs have been included in this study. We calculated compliance (percentage of FDRs who underwent surveillance colonoscopy among those eligible), appropriateness of colonoscopy (appropriate if performed within 6 months of the guidelines recommended interval) and diagnostic yield for neoplasia. We compared these data with those of 765 individuals without a family history (FH) of CRC who underwent screening colonoscopy in the same period (controls). RESULTS: Compliance and appropriateness were higher in FDRs than in controls (93.0% vs. 48.0%; p < 0.001; 59.6% vs. 18.8%; p < 0.0001, respectively). Younger age, female sex, FH of CRC and both non-advanced adenomas (nAA) and advanced adenomas (AA) at screening colonoscopy were predictors of appropriate surveillance. The cumulative incidence of nAA and AA was similar in FDRs and controls (31.7% and 4.9% in FDRs, including three invasive cancers; 32.4% and 5.8% in controls, respectively). CONCLUSION: FH does not increase the risk of AA in a 5-year follow-up; appropriate surveillance practices in FDRs could be highly expected in an organized screening program.


Subject(s)
Adenoma/diagnostic imaging , Colonoscopy , Colorectal Neoplasms/diagnostic imaging , Colorectal Neoplasms/epidemiology , Population Surveillance/methods , Adenoma/genetics , Age Factors , Aged , Colorectal Neoplasms/genetics , Early Detection of Cancer/standards , Female , Follow-Up Studies , Guidelines as Topic , Humans , Incidence , Italy/epidemiology , Male , Middle Aged , Patient Compliance , Pedigree , Prospective Studies , Sex Factors , Time Factors
2.
Gut ; 66(11): 1949-1955, 2017 11.
Article in English | MEDLINE | ID: mdl-27507903

ABSTRACT

OBJECTIVE: Miss rate of polyps has been shown to be substantially lower with full-spectrum endoscopy (FUSE) compared with standard forward-viewing (SFV) colonoscopy in a tandem study at per polyp analysis. However, there is uncertainty on whether FUSE is also associated with a higher detection rate of colorectal neoplasia, especially advanced lesions, in per patient analysis. METHODS: Consecutive subjects undergoing colonoscopy following a positive faecal immunochemical test (FIT) by experienced endoscopists and performed in the context of a regional colorectal cancer population-screening programme were randomised between colonoscopy with either FUSE or SFV colonoscopy in seven Italian centres. Randomisation was stratified by gender, age group and screening history. Primary outcomes included detection rates of advanced adenomas (A-ADR), adenomas (ADR) and sessile-serrated polyps (SSPDR). RESULTS: Of 741 eligible subjects, 658 were randomised to either FUSE (n=328) or SFV (n=330) colonoscopy and included in the analysis. Overall, 293/658 and 143/658 subjects had at least one adenoma (ADR 44.5%) and advanced adenoma (A-ADR 21.7%), respectively, while SSP was the most advanced lesion in 18 cases (SSPDR 2.7%). ADR and A-ADR were 43.6% and 19.5% in the FUSE arm, and 45.5% and 23.9% in the SFV arm, with no difference for both ADR (OR for FUSE: 0.96, 95% CI 0.81 to 1.14) and A-ADR (OR for FUSE: 0.82, 95% CI 0.61 to 1.09). No difference in SSPDR or multiplicity was detected between the two arms. In the per polyp analysis, the mean number of adenomas and proximal adenomas per patient was 0.81±1.25 and 0.47±0.93 in the FUSE arm, and 0.85±1.33 and 0.48±0.96 in the SFV colonoscopy arm (p=NS for both comparisons). CONCLUSIONS: No statistically significant difference in ADR and A-ADR between FUSE and SFV colonoscopy was detected in a per patient analysis in FIT-positive patients. TRIAL REGISTRATION NUMBER: ISRCTN10357435.


Subject(s)
Adenoma/diagnostic imaging , Colonoscopy/methods , Colorectal Neoplasms/diagnostic imaging , Early Detection of Cancer/methods , Mass Screening/methods , Aged , Female , Humans , Italy , Male , Middle Aged , Models, Statistical , Single-Blind Method
3.
Assist Inferm Ric ; 32(2): 84-91, 2013.
Article in Italian | MEDLINE | ID: mdl-23877495

ABSTRACT

INTRODUCTION: The phosphate-containing enemas are widely used, both to manage constipation and as a preparation for endoscopic procedures and surgery in adults and children. Many studies report that the use of these laxatives can be dangerous. OBJECTIVE: To identify possible prevention strategies starting from a severe adverse reaction due to repeated administrations of phosphate enemas. METHODS: A working group was started, the literature was reviewed and recommendations for an appropriate use of enemas were discussed and implemented, to improve patients' safety. RESULTS: Phosphate-containing enemas were replaced with 125 ml water enemas; recommendations were spread to strongly limit the use of phosphate containing enemas and the use of laxative in the first and second semester of 2012, were confronted showing a change in habits and a reduction in the use of phosphate containing enemas. CONCLUSIONS: The implementation of several strategies, originated from an adverse event, succeeded in modifying the use of laxatives and phosphate-containing enemas.


Subject(s)
Constipation/nursing , Enema/nursing , Laxatives/adverse effects , Phosphoric Monoester Hydrolases/adverse effects , Adult , Aged , Algorithms , Child, Preschool , Constipation/therapy , Enema/adverse effects , Female , Humans , Laxatives/administration & dosage , Nursing Audit , Phosphoric Monoester Hydrolases/administration & dosage , Practice Guidelines as Topic , Risk Assessment , Risk Factors
4.
Ann Surg ; 256(5): 788-94; discussion 794-5, 2012 Nov.
Article in English | MEDLINE | ID: mdl-23095623

ABSTRACT

OBJECTIVE: To establish the incidence and risk factors for progression to high-grade intraepithelial neoplasia (HG-IEN) or Barrett's esophageal adenocarcinoma (BAc) in a prospective cohort of patients with esophageal intestinal metaplasia [(BE)]. BACKGROUND: BE is associated with an increased risk of BAc unless cases are detected early by surveillance. No consistent data are available on the prevalence of BE-related cancer, the ideal surveillance schedule, or the risk factors for cancer. METHODS: In 2003, a regional registry of BE patients was created in north-east Italy, establishing the related diagnostic criteria (endoscopic landmarks, biopsy protocol, histological classification) and timing of follow-up (tailored to histology) and recording patient outcomes. Thirteen centers were involved and audited yearly. The probability of progression to HG-IEN/BAc was calculated using the Kaplan-Meier method; the Cox regression model was used to calculate the risk of progression. RESULTS: HG-IEN (10 cases) and EAc (7 cases) detected at the index endoscopy or in the first year of follow-up were considered to be cases of preexisting disease and excluded; 841 patients with at least 2 endoscopies {median, 3 [interquartile range (IQR): 2-4); median follow-up = 44.6 [IQR: 24.7-60.5] months; total 3083 patient-years} formed the study group [male/female = 646/195; median age, 60 (IQR: 51-68) years]. Twenty-two patients progressed to HG-IEN or BAc (incidence: 0.72 per 100 patient-years) after a median of 40.2 (26.9-50.4) months. At multivariate analysis, endoscopic abnormalities, that is, ulceration or nodularity (P = 0.0002; relative risk [RR] = 7.6; 95% confidence interval, 2.63-21.9), LG-IEN (P = 0.02, RR = 3.7; 95% confidence interval, 1.22-11.43), and BE length (P = 0.01; RR = 1.16; 95% confidence interval, 1.03-1.30) were associated with BE progression. Among the LG-IEN patients, the incidence of HG-IEN/EAc was 3.17 patient-years, that is, 6 times higher than in BE patients without LG-IEN. CONCLUSIONS: These results suggest that in the absence of intraepithelial neoplastic changes, BE carries a low risk of progression to HG-IEN/BAc, and strict surveillance (or ablative therapy) is advisable in cases with endoscopic abnormalities, LG-IEN or long BE segments.


Subject(s)
Adenocarcinoma/epidemiology , Adenocarcinoma/pathology , Barrett Esophagus/epidemiology , Barrett Esophagus/pathology , Esophageal Neoplasms/epidemiology , Esophageal Neoplasms/pathology , Precancerous Conditions/epidemiology , Precancerous Conditions/pathology , Adenocarcinoma/diagnosis , Aged , Barrett Esophagus/diagnosis , Disease Progression , Esophageal Neoplasms/diagnosis , Esophagoscopy , Female , Humans , Incidence , Italy/epidemiology , Male , Middle Aged , Precancerous Conditions/diagnosis , Proportional Hazards Models , Registries , Risk Factors , Statistics, Nonparametric
5.
Gastrointest Endosc ; 73(3): 527-534.e2, 2011 Mar.
Article in English | MEDLINE | ID: mdl-21353850

ABSTRACT

BACKGROUND: A screening colonoscopy is recommended in first-degree relatives (FDRs) of colorectal cancer patients; few prospective, controlled studies have evaluated colorectal findings in a population-based screening program. OBJECTIVE: To evaluate the prevalence of colorectal neoplasia (adenomas and adenocarcinomas) in this increased-risk population, to compare it with that of average-risk individuals, and to identify features that might allow risk stratification for neoplasia among FDRs. DESIGN: Cross-sectional study. SETTING: Population-based screening program in Trentino, Italy. PATIENTS: FDRs of colorectal cancer patients between 45 and 75 years of age with no history of hereditary colorectal cancer syndromes or inflammatory bowel disease. CONTROLS: Average-risk individuals undergoing screening colonoscopy. INTERVENTION: Screening colonoscopy. RESULTS: Neoplasia was found in 33.4% of 1252 FDRs and in 30.3% of 765 controls; advanced neoplasia was found in 11.3% of FDRs and in 6.3% of controls. Odds ratios (ORs) from the multivariate logistic regression analysis adjusted for age, sex, cecal intubation rates, and colon cleansing showed an increased risk of advanced neoplasia (OR 2.41; 95% CI, 1.69-3.43; P < .0001) in FDRs. Age older than 56 years (OR 1.83; 95% CI, 1.15-2.99; P = .013) and male sex (OR 2.17; 95% CI, 1.39-3.10; P < .001) are independent predictors of advanced neoplasia. LIMITATIONS: Italian subjects living in the same geographic area; of 4301 FDRs, 2521 were excluded. CONCLUSIONS: The increased risk of advanced neoplasia supports the current recommendation for colonoscopic screening in this group; age and sex may assist in risk stratification of these individuals.


Subject(s)
Adenocarcinoma/epidemiology , Adenoma/epidemiology , Colonoscopy , Colorectal Neoplasms/epidemiology , Genetic Predisposition to Disease , Adenocarcinoma/genetics , Adenocarcinoma/pathology , Adenoma/pathology , Aged , Colorectal Neoplasms/genetics , Colorectal Neoplasms/pathology , Cross-Sectional Studies , Early Detection of Cancer , Female , Humans , Incidence , Italy/epidemiology , Logistic Models , Male , Mass Screening , Middle Aged , Multivariate Analysis , Pedigree , Population Surveillance , Prevalence , Risk Factors
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