Quantification of temporomandibular joint space in patients with juvenile idiopathic arthritis assessed by cone beam computerized tomography.

OBJECTIVE: To describe a method to calculate the total intra-articular volume (inter-osseous space) of the temporomandibular joint (TMJ) determined by cone-beam computed tomography (CBCT). This could be used as a marker of tissue proliferation and different degrees of soft tissue hyperplasia in juvenile idiopathic arthritis (JIA) patients. MATERIALS AND METHODS: Axial single-slice CBCT images of cross-sections of the TMJs of 11 JIA patients and 11 controls were employed. From the top of the glenoid fossa, in the caudal direction, an average of 26 slices were defined in each joint (N = 44). The interosseous space was manually delimited from each slice by using dedicated software that includes a graphic interface. TMJ volumes were calculated by adding the areas measured in each slice. Two volumes were defined: Ve-i and Vi , where Ve-i is the inter-osseous space, volume defined by the borders of the fossa and Vi is the internal volume defined by the condyle. An intra-articular volume filling index (IF) was defined as Ve-i /Vi , which represents the filling of the space. RESULTS: The measured space of the intra-articular volume, corresponding to the intra-articular soft tissue and synovial fluid, was more than twice as large in the JIA group as in the control group. CONCLUSION: The presented method, based on CBCT, is feasible for assessing inter-osseus joint volume of the TMJ and delimits a threshold of intra-articular changes related to intra-articular soft tissue proliferation, based on differences in volumes. Intra-articular soft tissue is found to be enlarged in JIA patients.

Atypical Magnetic Behavior in the Incommensurate (CH3NH3)[Ni(HCOO)3] Hybrid Perovskite.

A plethora of temperature-induced phase transitions have been observed in (CH3NH3)[M(HCOO)3] compounds, where M is Co(II) or Ni(II). Among them, the nickel compound exhibits a combination of magnetic and nuclear incommensurability below Néel temperature. Despite the fact that the zero-field behavior has been previously addressed, here we study in depth the macroscopic magnetic behavior of this compound to unveil the origin of the atypical magnetic response found in it and in its parent family of formate perovskites. In particular, they show a puzzling magnetization reversal in the curves measured starting from low temperatures, after cooling under zero field. The first atypical phenomenon is the impossibility of reaching zero magnetization, even by nullifying the applied external field and even compensating it for the influence of the Earth's magnetic field. Relatively large magnetic fields are needed to switch the magnetization from negative to positive values or vice versa, which is compatible with a soft ferromagnetic system. The atypical path found in its first magnetization curve and hysteresis loop at low temperatures is the most noticeable feature. The magnetization curve switches from more than 1200 Oe from the first magnetization loop to the subsequent magnetization loops. A feature that cannot be explained using a model based on unbalanced pair of domains. As a result, we decipher this behavior in light of the incommensurate structure of this material. We propose, in particular, that the applied magnetic field induces a magnetic phase transition from a magnetically incommensurate structure to a magnetically modulated collinear structure.

Sample size bias in the empirical assessment of the acute risks associated with daylight saving time transitions.

The assessment of the acute impact of daylight saving time (DST) transitions is a question of great interest for an understanding of the benefits and inconveniences of a practice that is now under public scrutiny in Europe and America. Here, we report a thorough analysis of a record of 13 well-known research studies that reported increased risks associated with DST transitions in health issues - acute myocardial infarction, ischemic strokes and trauma admissions - and in societal issues - accidents, traffic accidents and fatal motor vehicle accidents. We found that a five percent increase of the risks suffices to understand the reported increased risks associated with the spring transition. Reported values above this threshold are impacted by the sample size of the study. In the case of the autumn transition, no increase in the risks is found.

New mathematical model based on geometric algebra for physical power flow in theoretical two-dimensional multi-phase power circuits.

This study proposes an explanation for the physical power flow in planar circuits by analogy to theoretical two-dimensional circuits using a new mathematical model based on Geometric Algebra (GA) and 2D Maxwell's equations. In contrast with traditional 3D physics in the observable real world, the magnetic field can be defined as a bivector instead of an axial vector allowing to obtain the Poynting Vector directly in a 2D flat world, where physical variables of planar circuits can be obtained. This approach is presented here for the first time to the best of the author's knowledge. Previous investigations have focused on simplifications and symmetries of real 3D circuits studied mainly in the phasor and frequency domain. In this work, the electromagnetic power flow phenomenon is analyzed on a completely 2D time-domain basis and derived directly from the undisputed Maxwell equations, formulated in two dimensions. Several cases of special interest in AC multi-phase circuits are presented using the proposed technique, bringing a new simplified approach to the measurement of power flow exchange between the source and the load. It suggests a new way to understand energy propagation from a purely physical point of view.

Assessing the risk of pandemic outbreaks across municipalities with mathematical descriptors based on age and mobility restrictions.

By March 14th 2022, Spain is suffering the sixth wave of the COVID-19 pandemic. All the previous waves have been intimately related to the degree of imposed mobility restrictions and its consequent release. Certain factors explain the incidence of the virus across regions revealing the weak locations that probably require some medical reinforcements. The most relevant ones relate with mobility restrictions by age and administrative competence, i.e., spatial constrains. In this work, we aim to find a mathematical descriptor that could identify the critical communities that are more likely to suffer pandemic outbreaks and, at the same time, to estimate the impact of different mobility restrictions. We analyze the incidence of the virus in combination with mobility flows during the so-called second wave (roughly from August 1st to November 30th, 2020) using a SEIR compartmental model. After that, we derive a mathematical descriptor based on linear stability theory that quantifies the potential impact of becoming a hotspot. Once the model is validated, we consider different confinement scenarios and containment protocols aimed to control the virus spreading. The main findings from our simulations suggest that the confinement of the economically non-active individuals may result in a significant reduction of risk, whose effects are equivalent to the confinement of the total population. This study is conducted across the totality of municipalities in Spain.

TMJ contrast enhancement in CBCT images using a new algorithm.

Magnetic resonance imaging (MRI) is considered the gold standard to reliably diagnose inflammation in the temporomandibular joint (TMJ) of patients with juvenile idiopathic arthritis (JIA). However, even MRI imaging is dependent on the familiarity of the radiologist with the normal appearance of the TMJ; therefore, new approaches are needed. Our purpose here is to improve imaging quality of cone beam computed tomography (CBCT) as a tool to help in the diagnosis of JIA in the TMJ. We have designed and applied a filter (the Stacking Enhancement Filter) over a stock of CBCT images from the TMJs of two patients with JIA. We then made a visual comparison of the results with archival images from MRI of the same patients, to show that the filter substantially improves the visual quality of the image. The work on the image contrast and the increase of the difference of appearance between tissues of different densities (all the anatomical structures that are present within the joint) leads to an improvement of the resulting images of the TMJ without the use of a chemical contrast agent. We conclude that CBCT could be used as a filter tool for the analysis of the TMJs affected by arthritis. Our image processing technique yields images that possible improve the range of use of CBCT.

Optimal control of the COVID-19 pandemic: controlled sanitary deconfinement in Portugal.

The COVID-19 pandemic has forced policy makers to decree urgent confinements to stop a rapid and massive contagion. However, after that stage, societies are being forced to find an equilibrium between the need to reduce contagion rates and the need to reopen their economies. The experience hitherto lived has provided data on the evolution of the pandemic, in particular the population dynamics as a result of the public health measures enacted. This allows the formulation of forecasting mathematical models to anticipate the consequences of political decisions. Here we propose a model to do so and apply it to the case of Portugal. With a mathematical deterministic model, described by a system of ordinary differential equations, we fit the real evolution of COVID-19 in this country. After identification of the population readiness to follow social restrictions, by analyzing the social media, we incorporate this effect in a version of the model that allow us to check different scenarios. This is realized by considering a Monte Carlo discrete version of the previous model coupled via a complex network. Then, we apply optimal control theory to maximize the number of people returning to "normal life" and minimizing the number of active infected individuals with minimal economical costs while warranting a low level of hospitalizations. This work allows testing various scenarios of pandemic management (closure of sectors of the economy, partial/total compliance with protection measures by citizens, number of beds in intensive care units, etc.), ensuring the responsiveness of the health system, thus being a public health decision support tool.

Dynamic Moduli of Polybutylene Terephthalate Glass Fiber Reinforced in High-Temperature Environments.

The aim of this work was to show the evolution over time of the dynamic moduli in components made of Polybutylene Terephthalate reinforced with glass fiber when they are held to temperatures close to the glass transition temperature over time. For this purpose, PBT samples reinforced with short, glass fibers of Ultradur® material with 0%, 20%, and 50% in weight content were tested. Dynamic moduli showed an increment with glass fiber content showing a nonlinear behavior with the temperature. The evolution of storage modulus was depicted by means of a modified law of mixtures with an effectiveness factor depending on temperature and fiber content, whereas the evolution over time was obtained with a time-temperature transformation generated with the TTS Data Analysis software of TA-instruments for a given temperature. Storage modulus showed a linear relationship with glass fiber content when components were held to temperatures near to their respective glass transition temperature, obtained from the maximum of loss modulus curve with temperature. In summary, the value and evolution of dynamic moduli of PBT samples improved with glass fiber content, allowing us to increase the durability of components when they are submitted to high-temperature environments.

Case Report: Effect of Haploscopic Filter on Contrast Sensitivity Function and Color Vision Tests.

SIGNIFICANCE: The options that can help patients with congenital color vision defect, to a better professional and leisure adaptation, are very limited. Different haploscopic lenses can be considered, and their effects need to be investigated in patients with different defects. PURPOSE: The purpose of this study was to present and discuss the effect of a pair of asymmetric long-pass filters fitted for deuteranopia, with the result of a 60% improvement in distinguishing red-green plates when compared with baseline. CASE REPORT: We report the case of a 51-year-old man with congenital deuteranopia fitted with haploscopic ChromaGen filters. During the 2-month follow-up, we observed a decrease in left-eye logMAR visual acuity and contrast sensitivity with an increased ability to discriminate the plates of different color vision tests (Ishihara, Farnsworth, and Hardy-Rand-Rittler). The visual outcomes are discussed considering the spectral sensitivity curves of each filter, measured with a spectrophotometric device. CONCLUSIONS: This report describes an improvement in the ability to resolve color vision plates after using asymmetric haploscopic filters showing a left-eye decrease in logMAR visual acuity and contrast sensitivity function. Subjects with a history of color vision deficiency might benefit from using haploscopic filters that selectively minimize the transmittance within a specific bandwidth to improve the color discrimination in deutan color vision deficiency. The simultaneous analysis of the color vision outcomes and transmittance spectrum of the haploscopic filters might contribute to a better understanding of the mechanisms behind the claimed efficacy of these devices.

Relationship between Corneal Morphogeometrical Properties and Biomechanical Parameters Derived from Dynamic Bidirectional Air Applanation Measurement Procedure in Keratoconus.

The morphogeometric analysis of the corneal structure has become a clinically relevant diagnostic procedure in keratoconus (KC) as well as the in vivo evaluation of the corneal biomechanical properties. However, the relationship between these two types of metrics is still not well understood. The current study investigated the relationship of corneal morphogeometry and volume with two biomechanical parameters: corneal hysteresis (CH) and corneal resistance factor (CRF), both provided by an Ocular Response Analyzer (Reichert). It included 109 eyes from 109 patients (aged between 18 and 69 years) with a diagnosis of keratoconus (KC) who underwent a complete eye examination including a comprehensive corneal topographic analysis with the Sirius system (CSO). With the topographic information obtained, a morphogeometric and volumetric analysis was performed, defining different variables of clinical use. CH and CRF were found to be correlated with these variables, but this correlation was highly influenced by corneal thickness. This suggests that the mechanical properties of KC cornea contribute only in a partial and limited manner to these biomechanical parameters, being mostly influenced by morphogeometry under normal intraocular pressure levels. This would explain the limitation of CH and CRF as diagnostic tools for the detection of incipient cases of KC.

Aproximación al tratamiento de la ludopatía en el sistema penal español / Approach to pathological gambling treatment inSpanish criminal law

El incremento de las casas de apuestas supone un aumento de la oportunidad para iniciarse en los juegos de azar, pero también para el desarrollo de patologías como la ludopatía. Lo mismo podría decirse respecto de la expansión del juego online, especialmente en sectores jóvenes de la población, atendiendo además a las facilidades que la tecnología ofrece respecto de las adicciones comportamentales. Este contexto supone un factor criminógeno que favorece la comisión de hechos delictivos relacionados con el juego patológico, con el objetivo de satisfacer las necesidades económicas de la persona para seguir jugando. De acuerdo con lo expuesto, en este trabajo se analiza el tratamiento penal de la ludopatía, considerando su afectación a la capacidad volitiva del sujeto, mediante la aplicación de la atenuante de análoga significación recogida en el art. 21.7 del Código penal. La descripción del marco legal sobre la imputabilidad y la atenuación de la pena en los casos de ludopatía es acompañada por un estudio de la jurisprudencia del Tribunal Supremo en lo relativo al tratamiento del juego patológico

The increasing number of betting offices entails an increase in opportunities to start gambling, but also concerning the development of pathologies such as compulsive gambling. The situation is the same with respect to the expansion of online gambling, specially focused on young people, according to the new context created by the incidence of technologies regarding behavioral addictions. This context entails a criminogenic risk which could lead to the committing of offences related to pathological gambling, with the purpose of feeding the gambling habit. In line with this issue, this paper analyses the treatment of compulsive gambling in Spanish criminal law, taking into account its effect on a person’s willpower, by means of the analogical mitigating circumstance regulated in art. 21.7 Criminal Code. The description of the legal framework regarding accountability and mitigation of the penalty in compulsive gambling is combined with a study about the Supreme Court case law related to pathological gambling treatment

Urbanity and the dynamics of language shift in Galicia.

Sociolinguistic phenomena often involve interactions across different scales and result in social and linguistic changes that can be tracked over time. Here, we focus on the dynamics of language shift in Galicia, a bilingual community in northwest Spain. Using historical data on Galician and Spanish speakers, we show that the rate at which shift dynamics unfold correlates inversely with the internal complexity of a region (approximated by the proportion of urban area). Less complex areas converge faster to steady states, while more complex ones sustain transitory dynamics longer. We further explore the contextual relevance of each region within the network of regions that constitute Galicia. The network is observed to sustain or reverse the dynamic rates. This model can introduce a competition between the internal complexity of a region and its contextual relevance in the network. Harnessing these sociodynamic features may prove useful in policy making to limit conflicts.

Coexistence of Three Ferroic Orders in the Multiferroic Compound [(CH3 )4 N][Mn(N3 )3 ] with Perovskite-Like Structure.

The perovskite azido compound [(CH3 )4 N][Mn(N3 )3 ], which undergoes a first-order phase change at Tt =310 K with an associated magnetic bistability, was revisited in the search for additional ferroic orders. The driving force for such structural transition is multifold and involves a peculiar cooperative rotation of the [MnN6 ] octahedral as well as order/disorder and off-center shifts of the [(CH3 )4 N](+) cations and bridging azide ligands, which also bend and change their coordination mode. According to DFT calculations the latter two give rise to the appearance of electric dipoles in the low-temperature (LT) polymorph, the polarization of which nevertheless cancels out due to their antiparallel alignment in the crystal. The conversion of this antiferroelectric phase to the paraelectric phase could be responsible for the experimental dielectric anomaly detected at 310 K. Additionally, the structural change involves a ferroelastic phase transition, whereby the LT polymorph exhibits an unusual and anisotropic thermal behavior. Hence, [(CH3 )4 N][Mn(N3 )3 ] is a singular material in which three ferroic orders coexist even above room temperature.

Impact of mindfulness training on attentional control and anger regulation processes for psychotherapists in training.

OBJECTIVES: Little empirical literature focuses on psychotherapists' cultivation of internal states of mind necessary for controlling attention and responding empathically to the client. We explore the effects of mindfulness training on emotional and attentional measures in Spanish resident intern psychiatrists and clinical psychologists. METHOD: One hundred and three residents were assigned to an experimental group (n = 60) that completed an 8-week mindfulness training versus a wait-list control group (n = 43). We evaluated emotional variables (sadness, anxiety, and anger, using standard instruments), state of mindfulness (using the Mindfulness Awareness Attention Scale), and attentional control variables using objective measures such as a continuous performance task and the Stroop task before and after mindfulness training. RESULTS: Our study provides data that suggest that mindfulness training significantly improves measures of trait anger and attentional control. CONCLUSIONS: Further research is needed to replicate these findings, explore the effects of mindfulness training on other aspects of emotional regulation and cognition, and evaluate the impact of these effects within clinical situations.