ABSTRACT
Considering the rising incidence and mortality of thyroid cancer (TC) worldwide, the aim of our study was to determine the risk factors for TC in a province with the highest incidence of TC in the country located at the South of Iran. A population-based case-control study was performed on 708 participants (361 new cases and 347 controls). The case participants were selected from the Iranian National Cancer Registry database. Frequency matched for gender and age, and the control participants were selected randomly from the neighborhood of the cases. Based on the results of multiple logistic regression analysis, benign thyroid diseases (eg, hyperthyroidism ORyes/no = 14.06, 95% CI: 5.13-38.51), family history of TC (ORyes/no = 3.54, 95% CI: 1.51-8.26), radiation exposure of the head (ORyes/no = 1.92, 95% CI: 1.03-3.60), family history of thyroid diseases (ORyes/no = 1.76, 95% CI: 1.19-2.62) and family history of other types of cancer (ORyes/no = 1.67, 95% CI: 1.01-2.74), significantly increased the risk of developing TC. On the other hand, high blood pressure (ORyes/no = 0.35, 95% CI: 0.19-0.64), higher education (ORcollege/illiterate = 0.54, 95% CI: 0.30-0.96), consumption of unsaturated fat (ORunsaturated/saturated = 0.59, 95% CI: 0.39-0.87) and being married (ORmarried/single = 0.60, 95% CI 0.37-0.98) were found to be protective factors. Some community-based interventions, for example, reduction in radiation exposure and screening members of families with underlying thyroid diseases may help in preventing or early diagnosis of TC. More studies on the health effects of local herbs are highly recommended.
Subject(s)
Thyroid Neoplasms/epidemiology , Thyroid Neoplasms/etiology , Adult , Case-Control Studies , Female , Follow-Up Studies , Humans , Incidence , Iran/epidemiology , Male , Middle Aged , Prognosis , Risk Factors , Thyroid Neoplasms/pathologyABSTRACT
PURPOSE: In Iran, cancers are the third leading cause of death, and gastrointestinal cancers are the primary cause of mortality among all the cancers. This study aimed to determine the trend of crude and age-standardized mortality rates (ASMR) for different types of gastrointestinal cancers over an 11-year period in Fars province (Iran). METHODS: In this study, all the mortality data for gastrointestinal cancers were derived from the Electronic Death Registration System (EDRS) between 2005 and 2015. Subsequently, we calculated the crude and age-standardized mortality rates (ASMR) and their trends for different types of gastrointestinal cancers based on age groups and gender over the study period. RESULTS: A total of 6547 deaths from gastrointestinal cancers were identified, with an average age of 66.0 ± 16.4 years. The crude and age-standardized mortality rates for gastrointestinal cancers were respectively 10.9 and 15.0 per 100,000 population in 2005 which significantly increased to 17.4 and 19.4 per 100,000 population in 2015 (P < 0.001). The ASMR for colon, pancreatic, and oral cancers showed an increasing trend; for small intestine cancers, a decreasing trend; and for esophageal, gastric, rectal, and hepatobiliary cancers displayed an almost constant trend. CONCLUSIONS: Our study shows a higher ASMR and an increasing trend of gastrointestinal cancers in Fars province. Prevention and early diagnosis programs with screening techniques should be implemented to control the mortality rate of gastrointestinal cancers in the future.
