1.
Hematology
; 16(6): 368-72, 2011 Nov.
Article
in English
| MEDLINE
| ID: mdl-22183072
ABSTRACT
This study evaluates the prognostic value of MAGE-A3 expression in 28 diffuse large B-cell lymphoma (DLBCL) patients. A significant association was observed between MAGE-A3 expressions, assessed by quantitative real-time RT-polymerase chain reaction (PCR), with advanced stages of disease (P < 0.05). Elevated serum lactate dehydrogenase (LDH) levels and International Prognostic Index (IPI) score were significantly higher in MAGE-A3-positive patients (P = 0.025 and P = 0.004, respectively). Expression of MAGE-A3 was associated with poor response to treatment and a significantly shorter overall survival (P < 0.001). Our data address new information in the association of MAGE-A3 expression and poor prognosis in DLBCL patients.
Subject(s)
Antigens, Neoplasm/genetics , Gene Expression Regulation, Neoplastic , Lymphoma, Large B-Cell, Diffuse/genetics , Neoplasm Proteins/genetics , Adolescent , Adult , Aged , Antigens, Neoplasm/metabolism , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Blotting, Western , Female , Humans , L-Lactate Dehydrogenase/blood , Lymphoma, Large B-Cell, Diffuse/drug therapy , Lymphoma, Large B-Cell, Diffuse/metabolism , Male , Middle Aged , Neoplasm Proteins/metabolism , Neoplasm Staging , Prognosis , Reverse Transcriptase Polymerase Chain Reaction , Survival Analysis , Time Factors , Treatment Outcome , Young Adult
2.
Leuk Res
; 34(9): 1121-2, 2010 Sep.
Article
in English
| MEDLINE
| ID: mdl-20452019
