ABSTRACT
OBJECTIVE: Numerous studies demonstrated the effect of grape on memory improvement. According to Iranian traditional medicine, "mavizË® as a specific type of dried grapes can effectively improve memory. However, there is no reported clinical trial on the effect of "mavizË® on memory improvement in humans. Hence, this study was conducted to investigate "mavizË® effect on memory in university students. MATERIALS AND METHODS: This randomized open-label clinical trial was conducted on a total number of 53 students of Shahed University, Tehran, Iran, from November 2017 to February 2018. The participants were randomly allocated into an intervention group (receiving "mavizË®, 25 g in the morning for 4 weeks) or a control group (who did not take "mavizË®). The Digit Span Task and the N-Back Task were used for the measurement of working memory at the pre- and post-intervention stages. RESULTS: According to the results, no significant differences were found between the two groups regarding age, gender, marital status, and initial working memory test scores. "mavizË® consumption produced a highly significant improvement in total working memory score in the Digit Span Task (5.18 vs. 2.35, p<0.001) and Acoustic Memory Span (1.29 vs. 0.62, p=0.021). Moreover, "mavizË® consumption significantly increased the percentage of true responses in the N-Back Task and reduced the mean reaction time in the first level of the task. CONCLUSION: "mavizË® consumption was improved working memory in young healthy adults.
