Are Nonagenarians Too Old For Total Hip Arthroplasty? An Evaluation of Morbidity and Mortality Within a Total Joint Replacement Registry.

A greater number of patients aged 90 and over will become candidates for total hip arthroplasty (THA) as the nonagenarian population continues to grow. This study evaluated the patient characteristics and incidence of postoperative morbidity and mortality of 183 nonagenarian THA patients among 43,543 primary THA patients followed by a total joint replacement registry. Nonagenarians had a greater number of comorbidities preoperatively, experienced a higher one year mortality and had a longer hospital length of stay. However, nonagenarians did not have an increased risk of infection, deep vein thrombosis or pulmonary embolism and postoperative mortality was within expected rates for individuals 90 years and older. Higher readmission rates, however, highlight the benefits of close follow up during a prolonged postoperative period.

Mortality after shoulder arthroplasty.

One year post-operative mortality among patients with primary elective total shoulder arthroplasty (ETSA) and traumatic shoulder arthroplasty (TSA) were compared to the general population of a large healthcare system. Standardized mortality ratios (SMRs) and 95% confidence intervals (CIs) were calculated. 614 ETSA patients, 1.0% one year mortality, and 168 TSA patients, 5.4% mortality rate, were evaluated. Patients with ETSA (SMR = 0.4, 95% CI 0.1-0.7) had lower odds of mortality than expected, while patients with TSA (SMR = 1.8, 95% CI 0.6-3.0) did not have higher than expected odds of mortality compared to the reference population. Understanding excess mortality following shoulder arthroplasty surgery allows providers to evaluate current practices and identify ways to optimize patients prior to surgery.

Can total knee arthroplasty be safely performed among nonagenarians? An evaluation of morbidity and mortality within a total joint replacement registry.

As the nonagenarian patient population continues to grow, more patients aged 90 and over will become candidates for total knee arthroplasty (TKA). This study evaluated the patient characteristics and incidence of postoperative morbidity and mortality of 216 nonagenarian TKA patients among 81,835 primary TKA patients followed by a total joint replacement registry. Nonagenarians had a greater number of comorbidities preoperatively, experienced a higher rate of deep vein thrombosis and 30 day mortality, and had a longer hospital length of stay. However, nonagenarians did not have an increased risk of infection nor pulmonary embolism and postoperative mortality was within expected rates for individuals 90 years and older. Higher readmission rates, however, highlight the benefits of close follow up during a prolonged postoperative period.

The effect of chronic kidney disease on total hip arthroplasty.

Patients with chronic kidney disease (CKD) undergoing total hip arthroplasty (THA) were evaluated for risk of revision, surgical site infection (SSI), thromboembolic events, mortality and readmission. 20,720 primary TKA cases were included (smaller sample for readmission evaluation, N = 9322). The prevalence of CKD among THA patients was 6.1% (N = 1269). After adjustment for age, gender, race, general health, and diabetes, CKD patients were at 1.4 (95% confidence interval 1.1-1.8) increased risk of readmission within 90 days. The adjusted risks for revision (overall, aseptic, and septic), SSI (deep and superficial), deep vein thrombosis, pulmonary embolism, and mortality (30-day, 90-day, ever) were not significantly different between patients with CKD and those without CKD. However, increased risk for 90-day readmission underscores that CKD patients are a fundamentally different population of patients.

Can total knee arthroplasty be safely performed in patients with chronic renal disease?

BACKGROUND AND PURPOSE: The prevalence of chronic renal disease (CRD) is rising worldwide. Patients with CRD are more likely to have associated medical problems and are at greater risk of postoperative morbidity and mortality. We evaluated patient characteristics and risk of early revision, surgical site infection (SSI), thromboembolic events, mortality, and re-admission of patients with CRD undergoing total knee arthroplasty (TKA). We hypothesized that this patient population would have higher rates of complications. PATIENTS AND METHODS: We conducted a retrospective analysis of data that had been prospectively collected by a Total Joint Replacement Registry. All primary TKAs performed from 2005 through 2010 were included. 41,852 primary TKA cases were evaluated, of which 2,686 (6.4%) TKA procedures had been performed in CRD patients. Patient characteristics, comorbidities, and general health status were evaluated. Cox proportional hazard regressions and logistic regressions were used to evaluate the association of CRD with outcomes while adjusting for confounding variables. Results - The mean age of the CRD cohort was 67 years and approximately two-thirds of the patients were female. The median follow-up time was 2.1 years. Compared to TKA patients without CRD the CRD patients were older, had poorer general health, and had a higher prevalence of comorbidities. They had a higher incidence of deep SSI (0.9% vs. 0.7%), superficial SSI (0.5% vs. 0.3%), deep vein thrombosis (0.6% vs. 0.4%), any-time mortality (4.7% vs. 2.4%), 90-day mortality (0.4% vs. 0.2%), and 90-day re-admission (10% vs. 6.0%) than patients without CRD. However, after adjustment for confounding variables, CRD patients were at 1.9 times (95% CI: 1.1-3.5) increased risk of superficial SSI, 1.3 times (CI: 1.1-1.6) increased risk of re-admission within 90 days, and 1.5 times (CI: 1.2-1.8) increased risk of mortality at any point after the procedure. The risks of all other complications were not statistically significantly different in patients with CRD compared to patients without CRD. CONCLUSIONS: CRD patients undergoing TKA have more comorbidities and a higher risk for superficial SSI, 90-day re-admission, and any-time mortality.

Angiotensin-converting enzyme activity: a novel way of assessing pulmonary changes during total knee arthroplasty.

Emboli after tourniquet release (TR) during total knee arthroplasty (TKA) occur in all patients. This may lead to fat embolism syndrome with lung injury. Angiotensin-converting enzyme (ACE) lines the pulmonary endothelium, and a decrease in ACE metabolism or hydrolysis of (3)HBPAP ((3)H-benzoyl-Phe-Ala-Pro; a substrate specific for ACE) has been associated with lung injury. We evaluated the association of this assay with pulmonary changes during TKA. Eleven consecutive patients undergoing bilateral TKA had the ACE assay performed perioperatively. We determined substrate hydrolysis and pulmonary capillary surface area (capillary perfusion index; CPI) and correlated it with pulmonary vascular resistance (PVR) and clinical outcome. Ten of the 11 patients demonstrated an increase in substrate hydrolysis and CPI along with a decrease in PVR after first or second TR when compared with baseline values (P < 0.05). In the other patient, PVR continued to increase even after TR, whereas CPI and substrate hydrolysis decreased after surgery. Whereas all others did well clinically, this patient developed confusion and hypoxemia. In previous studies, a decrease in PVR with an increase in CPI, as exhibited by the 10 patients, has been associated with pulmonary capillary recruitment. We believe this to be an important mechanism by which the lungs are able to accommodate the burden of emboli at the time of TR.

Perioperative morbidity following total knee arthroplasty among obese patients.

To study the relationship between patient weight and perioperative morbidity, 512 total knee arthroplasties performed in 406 patients were reviewed. Patient height, weight, medical history, length of hospital stay, discharge destination (home versus rehabilitation facility), and all complications were recorded. Height and weight were used to calculate a body mass index (BMI) for each patient. Examination of patient data ordered by BMI established positive correlations between BMI and a cardiac history (P=.02), a history of diabetes mellitus (P=.006), postoperative hospital stays >7 days (P=.03), discharge to a rehabilitation facility (P=.02), and the risk of a postoperative complication (P=.004). Further statistical examination revealed the greatest differences in patient data exist between patients with a BMI >35 and patients with a BMI < or = 35. Patients with the greater BMI (>35) had significantly higher rates of cardiac conditions (56% versus 33%, P=.0001) and diabetes mellitus (10.5% versus 4.1%, P=.03) than patients with a lower BMI (< or = 35). Although there were no significant differences in the rates of specific complications between the two groups, patients in the heavier group were more likely to experience a complication (38% versus 25%, P=.002) and multiple complications (9.3% versus 6.2%, P=.03) than patients in the lighter group.

Global Management of Total Hip and Total Knee Arthroplasty Patient Populations: a New, Comprehensive Approach to Deep Vein Thrombosis Prophylaxis.

Venous thromboembolic disease remains a common and potentially fatal complication after total joint arthroplasty. The incidence of deep vein thrombosis (DVT) has been reported to be between 5% and 60% in a number of studies using a variety of prophylaxis regimens. Symptomatic pulmonary embolism has been documented as high as 23%, while fatal pulmonary embolism, although relatively infrequent, remains one of the most catastrophic complications of total joint arthroplasty.