1.
Mutat Res
; 352(1-2): 23-30, 1996 Jun 10.
Article
in English
| MEDLINE
| ID: mdl-8676911
ABSTRACT
Thioacetamide is confirmed as active in the mouse bone marrow micronucleus assay, following single oral administration to both sexes of two different strains of mice (C57BL/6, BALB/c) in five separate experiments. Acetamide is shown to be consistently and clearly negative as a micronucleus-inducing agent in mouse bone marrow in four repeated assays using different sexes of two strains of mice (C57BL/6, CBA). The present findings support the adequacy of the limited micronucleus test protocol (male animals, two sampling times) for the efficient detection of genotoxic rodent carcinogens in this assay.
Subject(s)
Acetamides/toxicity , Carcinogens/toxicity , Micronucleus Tests/methods , Thioacetamide/toxicity , Animals , Bone Marrow , Female , Male , Mice , Mice, Inbred BALB C , Mice, Inbred C57BL , Mice, Inbred CBA , Rats
2.
Mutat Res
; 322(2): 142-4, 1994 Aug.
Article
in English
| MEDLINE
| ID: mdl-7519322
3.
Prog Clin Biol Res
; 340C: 397-405, 1990.
Article
in English
| MEDLINE
| ID: mdl-2381938
Subject(s)
Benzidines/toxicity , Coloring Agents/toxicity , Mutagens , Adult , Air Pollutants, Occupational/toxicity , Benzidines/metabolism , Carcinogens/toxicity , Chromosome Aberrations , Female , Humans , Lymphocytes/ultrastructure , Male , Micronuclei, Chromosome-Defective/drug effects , Middle Aged , Occupational Diseases/chemically induced , Smoking/genetics , Urinary Bladder Neoplasms/chemically induced
4.
Gig Sanit
; 36(4): 85-90, 1971 Apr.
Article
in Russian
| MEDLINE
| ID: mdl-4937843
