ABSTRACT
The serum levels of some indices of the LPO antioxidant system (dienic conjugates, antioxidative activity), cytokines (IL-1beta, TNF-alpha, IL-4) and the blood antiprotease system protein alpha2-macroglobulin were studied in 97 patients with closed long bone fractures. Based on the finding, a procedure was devised to evaluate the course of an inflammatory process in the early postoperative period, which predicted the development of pyoinflammatory complications at a stage of preclinical manifestations.
Subject(s)
Antioxidants/metabolism , Cytokines/blood , Fractures, Bone/blood , Inflammation/blood , Inflammation/diagnosis , Adult , Female , Fractures, Bone/complications , Fractures, Bone/diagnosis , Fractures, Bone/surgery , Humans , Inflammation/etiology , Male , Middle Aged , Postoperative Complications/blood , Postoperative Complications/diagnosis , Postoperative PeriodABSTRACT
Interleukine (IL-1alpha, IL-4) blood levels and lipid peroxidation--antioxidant agents were assessed in 98 patients with fractures of long tubular bones. Using the data, an algorithm was worked out, which permits prediction of septic complications with a high level of accuracy.
Subject(s)
Fractures, Bone/surgery , Fractures, Closed/surgery , Interleukin-1alpha/blood , Interleukin-4/blood , Surgical Wound Infection/diagnosis , Fractures, Bone/blood , Fractures, Bone/classification , Fractures, Closed/blood , Fractures, Closed/classification , Humans , Lipid Peroxidation , Prognosis , Suppuration/blood , Suppuration/diagnosis , Surgical Wound Infection/bloodABSTRACT
An investigation of the content of interleukins (IL-1alpha, IL-4) in blood serum, indices of the system of "LP-antioxidants" (DC, AOA) was performed in 92 patients with open fractures of long tubular bones. A method of early diagnosis of purulent complications in the postoperative period was worked out which allows timely necessary correction to be introduced in the plans of treatment.
