ABSTRACT
The article presents the publications' review considering the diagnostic value of dysfunction of endothelium. The almost ignored issue of dysfunction of endothelium under infection pathology in children is discussed.
Subject(s)
Endothelium/metabolism , Infections/diagnosis , Nitric Oxide , Child , Endothelium/pathology , Humans , Infections/metabolism , Infections/pathology , Membrane Proteins/metabolism , Nitric Oxide/metabolism , Nitric Oxide Synthase/drug effects , Nitric Oxide Synthase/metabolismABSTRACT
The serum levels of some indices of the LPO antioxidant system (dienic conjugates, antioxidative activity), cytokines (IL-1beta, TNF-alpha, IL-4) and the blood antiprotease system protein alpha2-macroglobulin were studied in 97 patients with closed long bone fractures. Based on the finding, a procedure was devised to evaluate the course of an inflammatory process in the early postoperative period, which predicted the development of pyoinflammatory complications at a stage of preclinical manifestations.
Subject(s)
Antioxidants/metabolism , Cytokines/blood , Fractures, Bone/blood , Inflammation/blood , Inflammation/diagnosis , Adult , Female , Fractures, Bone/complications , Fractures, Bone/diagnosis , Fractures, Bone/surgery , Humans , Inflammation/etiology , Male , Middle Aged , Postoperative Complications/blood , Postoperative Complications/diagnosis , Postoperative PeriodABSTRACT
Interleukine (IL-1alpha, IL-4) blood levels and lipid peroxidation--antioxidant agents were assessed in 98 patients with fractures of long tubular bones. Using the data, an algorithm was worked out, which permits prediction of septic complications with a high level of accuracy.
Subject(s)
Fractures, Bone/surgery , Fractures, Closed/surgery , Interleukin-1alpha/blood , Interleukin-4/blood , Surgical Wound Infection/diagnosis , Fractures, Bone/blood , Fractures, Bone/classification , Fractures, Closed/blood , Fractures, Closed/classification , Humans , Lipid Peroxidation , Prognosis , Suppuration/blood , Suppuration/diagnosis , Surgical Wound Infection/bloodABSTRACT
An investigation of the content of interleukins (IL-1alpha, IL-4) in blood serum, indices of the system of "LP-antioxidants" (DC, AOA) was performed in 92 patients with open fractures of long tubular bones. A method of early diagnosis of purulent complications in the postoperative period was worked out which allows timely necessary correction to be introduced in the plans of treatment.
