1.
Farmakol Toksikol
; 50(5): 78-88, 1987.
Article
in Russian
| MEDLINE
| ID: mdl-2826225
Subject(s)
Calcium Channel Blockers/pharmacology , Platelet Aggregation/drug effects , Animals , Blood Platelets/drug effects , Blood Platelets/metabolism , Calcium/blood , Calmodulin/antagonists & inhibitors , Cyclic AMP/blood , Depression, Chemical , Humans , Platelet Activating Factor/antagonists & inhibitors
2.
Farmakol Toksikol
; 50(2): 42-6, 1987.
Article
in Russian
| MEDLINE
| ID: mdl-3582633
ABSTRACT
It was found in experiments on rabbit platelets that isoptin and derivatives of N,N'-di(beta-phenylisopropyl)polymethylene diamines produce a dose-dependent decrease of the platelet aggregation activity. The effect correlates with a lowering of membrane-bound calcium level in platelets as shown by the fluorescent technique with the use of chlortetracycline probe. The results obtained demonstrate that the derivatives of alkylenediamines significantly suppress platelet aggregation and block membrane-bound calcium at the lower concentrations than those of isoptin.