ABSTRACT
Thermal lesions in children leave behind cicatricial contractions, contractures, deformations of the wrists, feet, face. Sanatorium-resort treatment using balneotherapy is an integral part of rehabilitation measures in such patients. OBJECTIVE: To analyze the results of hydrogen sulfide balneotherapy in children with consequences of thermal injury. MATERIAL AND METHODS: A single-center observational retrospective non-controlled study was carried out, in which sanatorium-resort treatment concerning post-burn scars in 812 children aged 5-17 years was analyzed. Hydrogen sulfide balneotherapy was prescribed to patients depending on the age in mild (5-6 years) or moderate-to-high (7-17 years) exposure modes. The imported hydrogen sulfide mineral water from the T-2000 well of the Matsesta field with the H2S total concentration of 410-420 mg/l was used for treatment. The applications were performed to children alternate days, 8 procedures of balneotherapy per course. RESULTS: Lightening of the affected areas of the skin, reduction of the sensation of contraction and tension of the scars, which became softer, more elastic and more mobile with regard to the subjacent tissues have been noted in patients after the course of balneotherapy. The head mobility increased after applications in the presence of scars. The large joints' range of motion grew up. In addition, an increase in the mobility of the fingers of wrists and feet, a decrease in the stiffness of movements, increase or recovery of the affected skin's tactile sensitivity have been observed. Children well tolerated procedures, adverse events were seen in 0.7% of cases in the form of mild reactions at the beginning of the applications' course, namely of balneological (0.6%) and toxico-allergic (0.1%) nature. CONCLUSION: Hydrogen sulfide balneotherapy in combination with rehabilitation exercises and other sanatorium-resort factors is an effective mean of post-burn scars correction in children.
Subject(s)
Balneology , Burns , Cicatrix , Health Resorts , Hydrogen Sulfide , Humans , Child , Child, Preschool , Adolescent , Male , Female , Burns/complications , Burns/therapy , Burns/rehabilitation , Balneology/methods , Cicatrix/therapy , Cicatrix/etiology , Cicatrix/rehabilitation , Retrospective StudiesABSTRACT
We consider the influence of extracellular signalling on neurite elongation in a model of neurite growth mediated by building proteins (e.g., tubulin). The tubulin production dynamics were supplied by a function describing the influence of extracellular signalling, which can promote or depress neurite elongation. We found that this extracellular feedback could generate neurite length oscillations consisting of a periodic sequence of elongations and retractions. The oscillations prevent further outgrowth of the neurite, which becomes trapped in the non-uniform extracellular field. We analysed the characteristics of the elongation process for different distributions of attracting and repelling sources of the extracellular signalling molecules. The model predicts three different scenarios of neurite development in the extracellular field, including monotonic and oscillatory outgrowth, localised limit cycle oscillations and complete growth depression.
Subject(s)
Feedback, Physiological , Models, Neurological , Neurites/physiology , Periodicity , Tubulin/physiologyABSTRACT
Experimental data are discussed and experience in complex treatment of 102 patients with acute pancreatitis with the application of intralesional+ electrophoresis is analysed. It was demonstrated in experiments on 90 albino rats that in intralesional+ electrophoresis of radioactive++ 5-fluorouracil (5-FU), its concentration in the pancreas was 2.4-3-fold that in the group of animals in which only intraperitoneal injections of the agent were given. Intralesional+ 5-FU, antibiotic, and contrykal electrophoresis was applied in the clinic in 75 patients with edematous and in 27 patients with destructive pancreatitis. Intralesional+ electrophoresis had a favourable effect on the course of acute pancreatitis, but its efficacy was lower in destructive pancreatitis. Intralesional+ electrophoresis made it possible to lower the general therapeutic doses of these agents and to reduce the number of injections per 24 hours. Three fatal outcomes occurred.
Subject(s)
Fluorouracil/administration & dosage , Iontophoresis/methods , Pancreas/drug effects , Pancreatitis/drug therapy , Acute Disease , Adult , Aged , Animals , Drug Evaluation, Preclinical , Fluorouracil/pharmacokinetics , Humans , Middle Aged , Pancreas/metabolism , Pancreatitis/metabolism , RatsABSTRACT
The effect of electrocumulation of 5-fluorouracil with the aid of electric field of constant current was studied in rats with experimental acute pancreatitis. 5-Fluorouracil was injected intraperitoneally in a dose of 4.5 mg per 100 g bw. Serum alpha-amylase, trypsin, trypsin inhibitor, lipase and total protease activity in the pancreatic tissue was studied as indicator of the treatment efficacy with 5-fluorouracil electro-cumulation. The levels of serum enzymes as well as the total proteolytic activity in the pancreatic tissue were far more decreased starting from the 3d-6th hour after induction of acute pancreatitis in rats treated by 5-fluorouracil with the aid of electric field of constant current as compared with other groups of rats.
