ABSTRACT
Depressive state in cancer patients is known to meet the criteria of mild depressive episode (F33.0) according to ICD-10. In the earlier stages of the disease and after successful treatment, depressive symptoms are usually combined with anxiety and obsessive fear, moderate appearances of ideator and motor inhibition, with permanent presence of asthenic symptoms. Once the disease is getting severer and the treatment is less successful, asthenia acquires hyposthenic features, with symptoms of apathy and dysphoria being attached. Cypramil was shown to be an effective medication in the treatment of depression in patients with malignant tumors of gastric-intestinal tract. The most efficient was the treatment conducted on the earlier stages of the cancer process and in cases of successful surgery and chemotherapy, in combination of depression with anxiety, anxious hypochondria, asthenia. Antidepressants must be used together with psychotherapy.
Subject(s)
Citalopram/therapeutic use , Depressive Disorder, Major/drug therapy , Depressive Disorder, Major/etiology , Gastrointestinal Neoplasms/psychology , Selective Serotonin Reuptake Inhibitors/therapeutic use , Adult , Citalopram/administration & dosage , Depressive Disorder, Major/diagnosis , Drug Administration Schedule , Female , Humans , Male , Middle Aged , Selective Serotonin Reuptake Inhibitors/administration & dosage , Severity of Illness IndexABSTRACT
Thirty one patients, aged 23-48 years, with ICD-10 diagnosis of psychogenic neurotic depression (F32.0 and F32.1), were studied. According to antidepressants used, the patients were divided into 2 groups, of which the test one included 19 patients treated by cipramil (20-40 mg/day) and the comparative one consisted of 12 patients treated with amitriptilin (25-50 mg/day). The treatment duration was 28 days. The patient's state was evaluated, using clinical approach and instrumental methods, i.e. Hamilton depression scale, before treatment and on 14th and 28th days. After cipramil treatment, 14 patients out of 19 exhibited an improvement, with 5 revealing neurotic symptoms compensation. However, 5 patients proved to be resistant to the medication. In amitriptilin treatment, complete depression reduction was found only in 1 patient, with pronounced improvement being shown in 8 out of 12 patients. No changes in the patient's state were revealed for 3 cases. Cipramil treatment was not accompanied with any side effects.
Subject(s)
Citalopram/therapeutic use , Depressive Disorder/drug therapy , Selective Serotonin Reuptake Inhibitors/therapeutic use , Adult , Humans , Middle Aged , Treatment OutcomeSubject(s)
Anti-Anxiety Agents/therapeutic use , Antidepressive Agents, Second-Generation/therapeutic use , Paroxetine/therapeutic use , Selective Serotonin Reuptake Inhibitors/therapeutic use , Anti-Anxiety Agents/adverse effects , Anti-Anxiety Agents/pharmacokinetics , Anti-Anxiety Agents/pharmacology , Antidepressive Agents, Second-Generation/adverse effects , Antidepressive Agents, Second-Generation/pharmacokinetics , Antidepressive Agents, Second-Generation/pharmacology , Anxiety/drug therapy , Depression/drug therapy , Humans , Paroxetine/adverse effects , Paroxetine/pharmacokinetics , Paroxetine/pharmacology , Selective Serotonin Reuptake Inhibitors/adverse effects , Selective Serotonin Reuptake Inhibitors/pharmacokinetics , Selective Serotonin Reuptake Inhibitors/pharmacologySubject(s)
Aging/psychology , Gastrointestinal Neoplasms/psychology , Psychophysiologic Disorders/diagnosis , Adult , Combined Modality Therapy , Gastrointestinal Neoplasms/etiology , Gastrointestinal Neoplasms/therapy , Humans , Middle Aged , Psychology, Social , Psychopathology , Psychophysiologic Disorders/psychology , Psychophysiologic Disorders/therapy , PsychotherapyABSTRACT
The studies which were conducted at a group of patients with endogenic psychosis and ulcer of stomach or duodenum have shown that the internal course of ulcer diseases might camouflage for a long period the existence of mental illness that would negatively influence upon the treatment of such patients. In particular these are the cases of continuous sluggish schizophrenia and affective psychosis. All the patients with inadequate course of somatic illness need psychiatric consultation in order to prove the absence of mental illness and choose an adequate medical tactics.
