ABSTRACT
The study of the use of ozone-containing solutions in 40 experimental animals and in 58 patients with diffuse purulent peritonitis revealed their marked detoxicant effect that manifested with early decrease of ESR, leucocytosis, plasma concentration of bilirubin and medium-size molecules, and microbes. Lethality in the experimental and control group were 5.2 and 16.6% respectively.
Subject(s)
Ozone/therapeutic use , Peritonitis/drug therapy , Postoperative Complications/drug therapy , Adolescent , Adult , Animals , Humans , Male , Middle Aged , Postoperative Period , Rats , Solutions , Time FactorsABSTRACT
Comparative study of the microbicidal activity of some traditional (hydrogen peroxide, boric acid, nitrofurazone) and currently available (Baliz-2, dioxidine, chlorhexidine bigluconate, pervomur) antiseptics against the most commonly encountered causative agents of purulent surgical infection showed 0.8%, 1.2%, and 2.4% pervomur solutions to possess the highest bactericidal and sporicidal activity. This circumstance allowed weak (0.8 and 1.2%) solutions of pervomur to be used in the clinic in 68 patients for the management of purulent postoperative complications and localized purulent infection, which improved the results of treatment significantly.
Subject(s)
Anti-Infective Agents, Local/therapeutic use , Bacterial Infections/drug therapy , Surgical Wound Infection/drug therapy , Anti-Infective Agents, Local/pharmacology , Bacterial Infections/microbiology , Boric Acids/pharmacology , Boric Acids/therapeutic use , Enterobacteriaceae/drug effects , Humans , Hydrogen Peroxide/pharmacology , Hydrogen Peroxide/therapeutic use , In Vitro Techniques , Nitrofurazone/pharmacology , Nitrofurazone/therapeutic use , Pseudomonas aeruginosa/drug effects , Quinoxalines/pharmacology , Quinoxalines/therapeutic use , Staphylococcus aureus/drug effects , Surgical Wound Infection/microbiologyABSTRACT
The author used 0.8 and 1.2% solutions of pervomur for complex treatment of purulent postoperative complications and local purulent infection by the method of washing drainage and application in 68 patients which made healing the wound quicker and shortened staying of the patients at the hospital. The authors recommend to widely use solutions of pervomur in complex treatment of purulent wounds especially infected by anaerobic infection.
