ABSTRACT
It was demonstrated in experiments on mice [correction of rats] that the transport of organophosphorus compounds (OPC) through membranes of the histohematic barriers (HHB) of the organism occurs by means of diffusion. The rate of this process depends on the interaction of OPC with the specific sites of binding with the tissues, among which the enzyme carboxylesterase plays an important part. It is suggested that both the rate and direction of OPC diffusion are determined by the relationship between the values of affinity of the ligands for the sites of their specific binding found on both sides of the HHB.
Subject(s)
Cholinesterase Inhibitors/pharmacokinetics , Isoflurophate/pharmacokinetics , Plasma/metabolism , Trichlorfon/pharmacokinetics , Tritolyl Phosphates/pharmacokinetics , Animals , Binding Sites/drug effects , Biological Transport/drug effects , Brain/drug effects , Brain/metabolism , Cholinesterase Inhibitors/toxicity , Diffusion/drug effects , Isoflurophate/toxicity , Liver/drug effects , Liver/metabolism , Mice , Plasma/drug effects , Tissue Distribution/drug effects , Trichlorfon/toxicity , Tritium , Tritolyl Phosphates/toxicityABSTRACT
The action of amino acids prevalent in soy bean proteins, as compared to casein, on lipid metabolism was studied. Administration of aspartate to experimental hyperlipidemic rats produced a pronounced hypocholesterolemic effect and led to an increased alpha-cholesterol level. Addition of glycine, arginine and cysteine to aspartate raised the hypocholesterolemic effect. However, under these conditions the content of triglycerides in the liver as well as their levels in the blood serum of intact experimental animals were increased.
Subject(s)
Amino Acids/therapeutic use , Lipid Metabolism , Animals , Drug Combinations , Drug Evaluation, Preclinical , Electrophoresis, Polyacrylamide Gel , Hypercholesterolemia/drug therapy , Hypercholesterolemia/metabolism , Hyperlipidemias/drug therapy , Hyperlipidemias/metabolism , Lipids/analysis , Liver/drug effects , Liver/metabolism , Male , RatsABSTRACT
Arginine decreased cholesterol and triglyceride content in blood sera of intact rats and inhibited the development of hyperlipidemia provoked by Triton WR-1339 injection. In rabbits pretreated with cholesterol arginine diminished the content of blood serum cholesterol and triglycerides. Introduction of arginine to intact and hyperlipidemic guinea pigs decreased the VLDL and increased the HDL level. Under influence of arginine electrophoretic zone of HDL apo A-1 was more pronounced and apo E zone became less distinct in hyperlipidemic guinea pigs.