ABSTRACT
Geographical distribution of individual genotypes of Helicobacter pylori, predominance of virulent types in various regions of Russia, particularly in the Prymorye Territory, remains unclear. We examined 115 children with various gastroduodenal pathology and 33 patients with gastric cancer, of which 57.39 and 60% respectively were infected with H. pylori. All samples positive for H. pylori were further analyzed for gene vacA mosaicism. In all clinical subgroups, variants s1 and m1 predominated; the frequency of genotype s1 was significantly increased (1.3-fold) in the group of cancer patients in comparison with the group of children with gastroduodenal pathology. Three variants of allele combination of signaling and middle regions of the vacA gene (s1m1, s1m2, and s2m2) were revealed; s1m1 was the most frequent in both groups. We suggest that this genotype is a marker of complicated course of gastroduodenitis and a factor of gastric cancer development in local population.
Subject(s)
Bacterial Proteins/genetics , Duodenal Diseases/microbiology , Gastrointestinal Diseases/microbiology , Helicobacter Infections/microbiology , Helicobacter pylori/genetics , Stomach Neoplasms/microbiology , Adolescent , Adult , Child , Duodenal Diseases/epidemiology , Female , Gastrointestinal Diseases/epidemiology , Gene Frequency , Genes, Bacterial , Genetic Markers , Genetic Variation , Genotype , Helicobacter Infections/epidemiology , Humans , Male , Prevalence , Russia/epidemiology , Stomach Neoplasms/epidemiologyABSTRACT
Adsorbability of alginic acid and its salts extracted from brown seaweeds and character of their biological action were studied. The results of clinical tests alginic acid and its salts as well as of preparations and food-stuffs, prepared from Laminaria japonica Arech, were reflected. The potentialities of use of alginates and food-stuffs containing them in therapeutic nutrition was shown.
