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2.
Prev Chronic Dis ; 20: E52, 2023 Jun 22.
Article in English | MEDLINE | ID: mdl-37347779

ABSTRACT

Food insecurity and obesity coexist among children and families. We examined the association between receipt of plant-based family food packages from the Massachusetts General Hospital Revere Food Pantry and change in body mass index (BMI), adjusted for age and sex, among children during the COVID-19 pandemic. Among 35 children aged 2 to 18 years who received the packages between January 2021 and February 2022, we observed a change in BMI of -0.04 kg/m2 (95% CI, -0.08 kg/m2 to -0.01 kg/m2) for each package received. Our results suggest plant-based food packages might mitigate, and potentially reverse, BMI increase in children in households seeking food assistance.


Subject(s)
COVID-19 , Food Assistance , Humans , Child , Pandemics , COVID-19/epidemiology , Body Mass Index , Obesity/epidemiology , Food Supply/methods
3.
Healthc (Amst) ; 9(4): 100589, 2021 Dec.
Article in English | MEDLINE | ID: mdl-34628211

ABSTRACT

Food insecurity is defined by limited access to adequate food. As a result, it is associated with chronic disease for millions of Americans. Healthcare systems take responsibility for improving patient health and thus are well positioned to create food security interventions that improve health. Given that dietary recommendations now emphasize plant-based foods (such as vegetables, fruits, legumes, and whole grains), interventions could prioritize distributing plant-based foods that promote health and reduce food insecurity. We developed a plant-based food pantry at the Massachusetts General Hospital Revere Healthcare Center, an academic medical center-affiliated community clinic that serves many patients with food insecurity. We partnered with a local food bank and used a color-coded nutrition ranking system to prioritize healthy foods. What began as a pilot program for patients with food insecurity and chronic disease expanded to serve the entire clinic population in response to rising community level food insecurity resulting from the COVID-19 pandemic. We developed and modified a workflow that provided an average of 384 recipients (i.e., patients and their household members) with food monthly during the 10-month study period. A total of 117,742 pounds of food was distributed. Next steps for the food pantry will include investigating health outcomes, assessing patient satisfaction with plant-based foods, and securing sustainable funding. Our experience can be used to guide other health organizations interested in the intersection of food security and chronic disease management.


Subject(s)
COVID-19 , Food Assistance , Academic Medical Centers , Food Supply , Health Promotion , Hospitals, General , Humans , Hunger , Pandemics , SARS-CoV-2 , United States
4.
Am J Health Promot ; 35(7): 904-907, 2021 09.
Article in English | MEDLINE | ID: mdl-33906426

ABSTRACT

As health care systems respond to the COVID-19 pandemic, new virtual care approaches are emerging for health promotion and chronic disease management. Virtual group visits (VGVs) supporting a healthy lifestyle, adapted from the well-established shared medical appointment (SMA) model, hold promise as a primary care delivery tool for preventing and managing chronic disease. In order to establish VGVs as standard of care, evidence for clinical effectiveness, financial sustainability, and access for vulnerable populations is needed. In the future, VGVs could improve the quality and reach of chronic disease prevention and management strategies.


Subject(s)
COVID-19 , Telemedicine , Chronic Disease , Disease Management , Humans , Pandemics/prevention & control , Primary Health Care , SARS-CoV-2
5.
Am J Manag Care ; 26(8): 329-330, 2020 08.
Article in English | MEDLINE | ID: mdl-32835459

ABSTRACT

In the coronavirus disease 2019 (COVID-19) era, clinical registries and innovative virtual care delivery tools should be leveraged to engage populations in effective chronic disease management.


Subject(s)
Chronic Disease/therapy , Coronavirus Infections/epidemiology , Patient Care Management/trends , Pneumonia, Viral/epidemiology , Telemedicine/trends , Betacoronavirus , COVID-19 , Humans , Pandemics , Practice Patterns, Physicians'/trends , SARS-CoV-2 , Virtual Reality
6.
J Health Commun ; 21(1): 85-91, 2016.
Article in English | MEDLINE | ID: mdl-26332306

ABSTRACT

To explore the content of patient-provider e-mails in a safety-net primary care clinic, we conducted a content analysis using inductive and deductive coding of e-mail exchanges (n = 31) collected from January through November 2013. Participants were English-speaking adult patients with a chronic condition (or their caregivers) cared for at a single publicly funded general internal medicine clinic and their primary care providers (attending general internist physicians, clinical fellows, internal medicine residents, and nurse practitioners). All e-mails were nonurgent. Patients included a medical update in 19% of all e-mails. Patients requested action in 77% of e-mails, and the most common requests overall were for action regarding medications or treatment (29%). Requests for information were less common (45% of e-mails). Patient requests (n = 56) were resolved in 84% of e-mail exchanges, resulting in 63 actions. These results show that patients in safety-net clinics are capable of safely and effectively using electronic messaging for between-visit communication with providers. Safety-net systems should implement electronic communications tools as soon as possible to increase health care access and enhance patients' involvement in their care.


Subject(s)
Electronic Mail/statistics & numerical data , Physician-Patient Relations , Primary Health Care , Safety-net Providers , Aged , Chronic Disease , Female , Humans , Male , Middle Aged , Observation , Poverty , Qualitative Research
7.
J Am Med Inform Assoc ; 23(1): 202-6, 2016 Jan.
Article in English | MEDLINE | ID: mdl-26177659

ABSTRACT

BACKGROUND: The high prevalence of limited health literacy among patients threatens the success of secure electronic messaging between patients from diverse populations and their providers. OBJECTIVE: The purpose of this study is to generate hypotheses about the readability of patient and provider electronic messages. METHODS: We collected 31 patient-provider e-mail exchanges (n = 119 total messages) from a safety-net primary care clinic. We compared the messages' mean word count and Flesch-Kincaid Grade Levels (FKGLs), calculated the frequency of provider messages below an FKGL = 8, and assessed readability concordance between patients' and providers' messages. RESULTS: Patients used more words in their initial e-mails compared to providers, but the FKGLs were similar, and 68% of provider messages were written below an FKGL = 8. Of 31 exchanges, 9 (29%) contained at least one patient message with an FKGL > 3 grade levels lower than the corresponding provider message(s). CONCLUSION: Our study demonstrates that most providers are able to respond to patient electronic messages with a matching reading level.


Subject(s)
Comprehension , Electronic Mail , Health Personnel , Humans , Patients , Primary Health Care
8.
Neuroimage ; 95: 61-8, 2014 Jul 15.
Article in English | MEDLINE | ID: mdl-24675647

ABSTRACT

Decline in executive function is the most common age-associated cognitive deficit and may be a risk factor for neurodegenerative disease. The antisaccade (AS) task involves inhibition of a prepotent visuomotor response and is a well-validated executive function test in aging and neurodegeneration. We investigated the functional connectivity of the cortical oculomotor network during successful AS performance in healthy elders. Elevated BOLD activity in the right lateral frontal eye field (rlatFEF), a region linked to volume loss in individuals with impaired AS performance, was associated with worse AS performance and weaker network efficiency. In contrast, hub integrity of the right dorsolateral prefrontal cortex (rDLPFC) and anterior cingulate cortex (rACC) was associated with better AS performance. These data suggest that while several right lateral frontal regions are central nodes in the oculomotor network, the rlatFEF demonstrates early neural aberrations and the rDLPFC and rACC continue to support inhibitory cognitive control in healthy elders. We conclude that alterations in AS task functional connectivity, quantified as hub and network efficiency, may be clinically-relevant biomarkers of cognitive decline in executive functioning.


Subject(s)
Aging/physiology , Brain/physiopathology , Executive Function/physiology , Neural Pathways/physiopathology , Aged , Aged, 80 and over , Brain Mapping , Female , Humans , Image Processing, Computer-Assisted , Magnetic Resonance Imaging , Male , Middle Aged , Saccades
9.
Neurology ; 81(14): 1235-43, 2013 Oct 01.
Article in English | MEDLINE | ID: mdl-23986300

ABSTRACT

OBJECTIVE: The aims of this study were to examine executive dysfunction using an antisaccade (AS) task in normal elderly (NE) and patients with mild cognitive impairment (MCI) and Alzheimer disease (AD) as well as to evaluate the relationship between AS performance and cortical thinning within AD-associated regions. METHODS: We recorded eye movements in 182 subjects (NE: 118; MCI: 36; AD: 28) during an AS task. We also performed neuropsychological measures of executive function for comparison. Brain MRI scans were collected on most subjects, and cortical thickness was determined in 9 regions known to exhibit atrophy in AD dementia ("AD signature"). We investigated the relationships between AS and neuropsychological performance, as well as possible correlations between AS performance and cortical thickness. RESULTS: AS performance in MCI resembled that in NE; subjects with AD were impaired relative to both MCI and NE. In all subjects, AS performance correlated with neuropsychological measures of executive function, even after controlling for disease severity. In the subjects with MCI but not in NE, cortical thickness in frontoparietal AD signature regions correlated with AS performance. CONCLUSIONS: The AS task is a useful measure of executive function across the AD spectrum. In MCI, AS performance may reflect disease burden within cortical brain regions involved in oculomotor control; however, AS impairments in NE may have etiologies other than incipient AD.


Subject(s)
Aging/physiology , Alzheimer Disease/physiopathology , Cerebral Cortex/physiopathology , Cognitive Dysfunction/physiopathology , Executive Function/physiology , Aged , Aged, 80 and over , Aging/pathology , Alzheimer Disease/pathology , Cerebral Cortex/pathology , Cognitive Dysfunction/pathology , Female , Frontal Lobe/pathology , Frontal Lobe/physiopathology , Humans , Magnetic Resonance Imaging , Male , Middle Aged , Neuropsychological Tests , Parietal Lobe/pathology , Parietal Lobe/physiopathology , Saccades/physiology , Severity of Illness Index
10.
Ann Neurol ; 73(5): 603-16, 2013 May.
Article in English | MEDLINE | ID: mdl-23536287

ABSTRACT

OBJECTIVE: Progressive supranuclear palsy (PSP) has been conceptualized as a large-scale network disruption, but the specific network targeted has not been fully characterized. We sought to delineate the affected network in patients with clinical PSP. METHODS: Using task-free functional magnetic resonance imaging, we mapped intrinsic connectivity to the dorsal midbrain tegmentum (dMT), a region that shows focal atrophy in PSP. Two healthy control groups (1 young, 1 older) were used to define and replicate the normal connectivity pattern, and patients with PSP were compared to an independent matched healthy control group on measures of network connectivity. RESULTS: Healthy young and older subjects showed a convergent pattern of connectivity to the dMT, including brainstem, cerebellar, diencephalic, basal ganglia, and cortical regions involved in skeletomotor, oculomotor, and executive control. Patients with PSP showed significant connectivity disruptions within this network, particularly within corticosubcortical and cortico-brainstem interactions. Patients with more severe functional impairment showed lower mean dMT network connectivity scores. INTERPRETATION: This study defines a PSP-related intrinsic connectivity network in the healthy brain and demonstrates the sensitivity of network-based imaging methods to PSP-related physiological and clinical changes.


Subject(s)
Brain/pathology , Brain/physiopathology , Nerve Net/pathology , Neural Pathways/pathology , Supranuclear Palsy, Progressive/pathology , Aged , Brain/blood supply , Brain Mapping , Female , Humans , Image Processing, Computer-Assisted , Magnetic Resonance Imaging , Male , Middle Aged , Nerve Net/physiopathology , Neural Pathways/blood supply , Oxygen/blood , Severity of Illness Index , Statistics as Topic
11.
Arch Neurol ; 69(4): 509-17, 2012 Apr.
Article in English | MEDLINE | ID: mdl-22491196

ABSTRACT

BACKGROUND: Deficits in the generation and control of saccades have been described in clinically defined frontotemporal dementia (FTD) and Alzheimer disease (AD). OBJECTIVE: To determine the saccade abnormalities associated with autopsy-defined cases of frontotemporal lobar degeneration (FTLD) and of AD, because clinical FTD syndromes can correspond to a number of different underlying neuropathologic FTD and non-FTD diagnoses. DESIGN: An infrared eye tracker was used to record visually guided saccades to 10° targets and antisaccades in subjects with autopsy-confirmed FTD and subjects with autopsy-confirmed AD, a mean (SE) of 35.6 (10.0) months prior to death, and age-matched normal controls. Twelve subjects with FTD had an FTLD-TAR DNA-binding protein 43 pathology, 15 had an FTLD-tau pathology, and 1 subject showed an FTLD-fused in sarcoma protein pathology. Receiver operating curve statistics were used to determine the diagnostic value of the oculomotor variables. Neuroanatomical correlates of oculomotor abnormalities were investigated using voxel-based morphometry. SETTING: Memory and Aging Center, Department of Neurology, University of California, San Francisco. PARTICIPANTS: A total of 28 subjects with autopsy-confirmed FTD, 10 subjects with autopsy-confirmed AD, and 27 age-matched normal controls. RESULTS: All subjects with FTD or AD were impaired relative to normal controls on the antisaccade task. However, only FTLD-tau and AD cases displayed reflexive visually guided saccade abnormalities. The AD cases displayed prominent increases in horizontal saccade latency that differentiated them from the FTD cases. Impairments in velocity and gain were most severe in individuals with progressive supranuclear palsy but were also present in other tauopathies. By using vertical and horizontal saccade velocity and gain as our measures, we were able to differentiate patients with progressive supranuclear palsy from other patients. Vertical saccade velocity was strongly correlated with dorsal midbrain volume. CONCLUSION: Decreased visually guided saccade velocity and gain are suggestive of underlying tau pathology in FTD, with vertical saccade abnormalities most diagnostic of progressive supranuclear palsy.


Subject(s)
Alzheimer Disease/complications , Frontotemporal Lobar Degeneration/complications , Ocular Motility Disorders/etiology , Saccades/physiology , Aged , Aged, 80 and over , Alzheimer Disease/diagnosis , Autopsy , Case-Control Studies , Chi-Square Distribution , Female , Frontotemporal Lobar Degeneration/diagnosis , Humans , Magnetic Resonance Imaging , Male , Middle Aged , Neuropsychological Tests , Psychiatric Status Rating Scales , ROC Curve
12.
Cogn Behav Neurol ; 24(2): 50-8, 2011 Jun.
Article in English | MEDLINE | ID: mdl-21697711

ABSTRACT

OBJECTIVE: To assess the neuropsychological and anatomical correlates of anti-saccade (AS) task performance in normal elders. BACKGROUND: The AS task correlates with neuropsychological measures of executive function and frontal lobe volume in neurological diseases, but has not been studied in a well-characterized normal elderly population. Because executive dysfunction can indicate an increased risk for cognitive decline in cognitively normal elders, we hypothesized that AS performance might be a sensitive test of age-related processes that impair cognition. METHOD: The percentage of correct AS responses was evaluated in 48 normal elderly subjects and associated with neuropsychological test performance using linear regression analysis and gray matter volume measured on magnetic resonance imaging scans using voxel-based morphometry. RESULTS: The percentage of correct AS responses was associated with measures of executive function, including modified trails, design fluency, Stroop inhibition, abstraction, and backward digit span, and correlated with gray matter volume in 2 brain regions involved in inhibitory control: the left inferior frontal junction and the right supplementary eye field. The association of AS correct responses with neuropsychological measures of executive function was strongest in individuals with fewer years of education. CONCLUSIONS: The AS task is sensitive to executive dysfunction and frontal lobe structural alterations in normal elders.


Subject(s)
Aging/physiology , Executive Function/physiology , Frontal Lobe/anatomy & histology , Saccades/physiology , Aged , Attention/physiology , Cognition/physiology , Female , Frontal Lobe/physiology , Humans , Magnetic Resonance Imaging , Male , Middle Aged , Neuropsychological Tests , Organ Size/physiology , Reaction Time/physiology
13.
Neuropsychologia ; 49(3): 468-78, 2011 Feb.
Article in English | MEDLINE | ID: mdl-21215762

ABSTRACT

While patients with Alzheimer's disease (AD) show deficits in attention, manifested by inefficient performance on visual search, new visual talents can emerge in patients with frontotemporal lobar degeneration (FTLD), suggesting that, at least in some of the patients, visual attention is spared, if not enhanced. To investigate the underlying mechanisms for visual talent in FTLD (behavioral variant FTD [bvFTD] and semantic dementia [SD]) patients, we measured performance on a visual search paradigm that includes both feature and conjunction search, while simultaneously monitoring saccadic eye movements. AD patients were impaired relative to healthy controls (NC) and FTLD patients on both feature and conjunction search. BvFTD patients showed less accurate performance only on the conjunction search task, but slower response times than NC on all three tasks. In contrast, SD patients were as accurate as controls and had faster response times when faced with the largest number of distracters in the conjunction search task. Measurement of saccades during visual search showed that AD patients explored more of the image, whereas SD patients explored less of the image before making a decision as to whether the target was present. Performance on the conjunction search task positively correlated with gray matter volume in the superior parietal lobe, precuneus, middle frontal gyrus and superior temporal gyrus. These data suggest that despite the presence of extensive temporal lobe degeneration, visual talent in SD may be facilitated by more efficient visual search under distracting conditions due to enhanced function in the dorsal frontoparietal attention network.


Subject(s)
Frontotemporal Lobar Degeneration/psychology , Visual Perception/physiology , Aged , Algorithms , Alzheimer Disease/pathology , Alzheimer Disease/psychology , Attention/physiology , Color , Eye Movements/physiology , Female , Fixation, Ocular , Frontotemporal Lobar Degeneration/pathology , Functional Laterality/physiology , Humans , Image Processing, Computer-Assisted , Magnetic Resonance Imaging , Male , Neuropsychological Tests , Oculomotor Muscles/physiology , Photic Stimulation , Psychomotor Performance/physiology , Reaction Time/physiology , Reading , Saccades/physiology
14.
J Neurol Neurosurg Psychiatry ; 82(2): 196-203, 2011 Feb.
Article in English | MEDLINE | ID: mdl-20562461

ABSTRACT

BACKGROUND: Frontotemporal dementia-amyotrophic lateral sclerosis (FTD-ALS) is a heritable form of FTD, but the gene(s) responsible for the majority of autosomal dominant FTD-ALS cases have yet to be found. Previous studies have identified a region on chromosome 9p that is associated with FTD and ALS. METHODS: The authors report the clinical, volumetric MRI, neuropathological and genetic features of a new chromosome 9p-linked FTD-ALS family, VSM-20. RESULTS: Ten members of family VSM-20 displayed heterogeneous clinical phenotypes of isolated behavioural-variant FTD (bvFTD), ALS or a combination of the two. Parkinsonism was common, with one individual presenting with a corticobasal syndrome. Analysis of structural MRI scans from five affected family members revealed grey- and white-matter loss that was most prominent in the frontal lobes, with mild parietal and occipital lobe atrophy, but less temporal lobe atrophy than in 10 severity-matched sporadic bvFTD cases. Autopsy in three family members showed a consistent and unique subtype of FTLD-TDP pathology. Genome-wide linkage analysis conclusively linked family VSM-20 to a 28.3 cM region between D9S1808 and D9S251 on chromosome 9p, reducing the published minimal linked region to a 3.7 Mb interval. Genomic sequencing and expression analysis failed to identify mutations in the 10 known and predicted genes within this candidate region, suggesting that next-generation sequencing may be needed to determine the mutational mechanism associated with chromosome 9p-linked FTD-ALS. CONCLUSIONS: Family VSM-20 significantly reduces the region linked to FTD-ALS on chromosome 9p. A distinct pattern of brain atrophy and neuropathological findings may help to identify other families with FTD-ALS caused by this genetic abnormality.


Subject(s)
Amyotrophic Lateral Sclerosis/genetics , Amyotrophic Lateral Sclerosis/pathology , Chromosomes, Human, Pair 9/genetics , Frontotemporal Dementia/genetics , Frontotemporal Dementia/pathology , Adult , Amyotrophic Lateral Sclerosis/complications , Autopsy , Brain/pathology , DNA Mutational Analysis , Family , Female , Frontotemporal Dementia/complications , Genetic Linkage , Genetic Predisposition to Disease , Genome-Wide Association Study , Haplotypes , Humans , Immunohistochemistry , Lod Score , Magnetic Resonance Imaging , Male , Middle Aged , Parkinson Disease/genetics , Pedigree
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