Retrospective analysis of time-related three-dimensional iliac bone graft resorption following sinus lift and vertical augmentation in the maxilla.

The atrophic maxilla frequently requires bone grafting using an onlay graft (OG) or sinus lifting (SL) before implant rehabilitation. The resorption of bone grafts is influenced by the time until implantation, quality of donor bone, and grafting technique. The aim of this study was to investigate the impact of both grafting techniques on the time-related resorption of autologous iliac bone graft. Forty-three patients underwent either onlay grafting or a sinus lift at 73 sites in the maxilla. Graft height was measured by cone beam computed tomography after augmentation and during follow-up for up to 12 months prior to implant insertion. The effect of time and technique on graft resorption was evaluated retrospectively. The reduction in bone graft height was greater for OG than SL over the investigated time intervals (OG = 51%, SL = 28%; P = 0.002). Each technique followed a specific course of resorption, which was independent of the initial graft height and could be calculated by a non-linear regression model. Iliac bone graft undergoes rapid resorption when used as an OG prior to implant insertion. For SL, this resorption is reasonably lower. This is especially crucial to determine the optimal time for implant insertion after graft healing to improve implant survival.

A simplified tempo-spatial model to predict airborne pathogen release risk in enclosed spaces: An Eulerian-Lagrangian CFD approach.

COVID19 pathogens are primarily transmitted via airborne respiratory droplets expelled from infected bio-sources. However, there is a lack of simplified accurate source models that can represent the airborne release to be utilized in the safe-social distancing measures and ventilation design of buildings. Although computational fluid dynamics (CFD) can provide accurate models of airborne disease transmissions, they are computationally expensive. Thus, this study proposes an innovative framework that benefits from a series of relatively accurate CFD simulations to first generate a dataset of respiratory events and then to develop a simplified source model. The dataset has been generated based on key clinical parameters (i.e., the velocity of droplet release) and environmental factors (i.e., room temperature and relative humidity) in the droplet release modes. An Eulerian CFD model is first validated against experimental data and then interlinked with a Lagrangian CFD model to simulate trajectory and evaporation of numerous droplets in various sizes (0.1 µm-700 µm). A risk assessment model previously developed by the authors is then applied to the simulation cases to identify the horizontal and vertical spread lengths (risk cloud) of viruses in each case within an exposure time. Eventually, an artificial neural network-based model is fitted to the spread lengths to develop the simplified predictive source model. The results identify three main regimes of risk clouds, which can be fairly predicted by the ANN model.

Reduction of metabolic signs of acute stress in male mice by Papaver rhoaes hydro-alcoholic extract.

In the present study, effects of hydro-alcoholic extract of Papaver rhoeas L. (Papaveraceae) on the metabolic changes induced by electro foot shock stress in male NMRI mice (25-30 g) has been investigated. The mice were received electric foot shock (40 mV) for 100 sec. Plasma corticosterone levels, food and water intake and delay to eating (Anorexia) were assessed 20 min later. Different doses of the plant extract (15, 30 and 60 mg kg(-1)), or saline (10 mL kg(-1)) was injected to the animals intraperitoneally 30 min before the stress. The control groups received saline (10 mL kg(-1)) or the extract (15, 30 and 60 mg kg(-1)) and 30 min later were exposed to the apparatus but did not received stress. Our results indicated that stress can increase plasma corticosterone level significantly and the extract can exacerbate the stress effect. However, stress could reduce food and water intake and increase delay to eating times which were inhibited by the extract pretreatment. The results indicate that administration of the extract of Papaver rhoeas can reduce the side effects of stress but increases plasma corticosterone level which may be due to its effects on the adrenal gland.