ABSTRACT
Experiments on rats showed that 6- and 12-day course treatment by mexidol or 2-ethyl-6-methyl-3-hydroxypyridine hemisuccinate (at doses 200 mg/kg, i.p.) prevented the lipofuscin level increase in rat brain tissue, caused by occlusion of the left middle cerebral artery, both in the damaged and intact (right) cerebral hemispheres. Mexidol significantly decreased the concentration of lipofuscine after 12-days treatment, whereas 2-ethyl-6-methyl-3-hydroxypiridine hemisuccinate markedly decreased lipofuscine levels already after 6-day treatment.
Subject(s)
Antioxidants/pharmacology , Brain Ischemia , Brain/metabolism , Lipofuscin/metabolism , Picolines/pharmacology , Pyridines/pharmacology , Animals , Brain/pathology , Brain Chemistry/drug effects , Brain Ischemia/drug therapy , Brain Ischemia/metabolism , Brain Ischemia/pathology , Male , RatsABSTRACT
We have studied the effect of a GABA conjugate with arachidonic acid (AA) on the morphological state of rat brain tissues after left median cerebral artery occlusion. The results showed that a 6- and 12-day course administration of the GABA - AA conjugate at dose of 2 mg/kg (i.p.) in rats with this model of local permanent brain ischemia led to significant recovery processes in brain tissues. The tissue morphology pattern in the group of animals treated with the GABSA - AA conjugate for 12 days was almost identical to that in intact tissues.
Subject(s)
Arachidonic Acids/pharmacology , Brain Ischemia , Neuroprotective Agents/pharmacology , gamma-Aminobutyric Acid/pharmacology , Animals , Brain Ischemia/drug therapy , Brain Ischemia/pathology , Disease Models, Animal , GABA Agents/pharmacology , Male , RatsABSTRACT
We compared the effects of a pyrrolidone-pyroglutamic acid composition and nimodipine on blood circulation in the middle cerebral artery in rats. The composition produced a strong effect on blood supply to the brain, stimulated blood flow in the middle cerebral artery (by 60 +/- 9%) and decreased blood pressure (by 25.0 +/- 2.7%). The cerebrovascular effects of this composition differed from those of nimodipine. Nimodipine not only increased middle cerebral artery blood flow, but also decreased cerebral blood flow in the early period after treatment.
