ABSTRACT
Popliteal cysts in children differ from those in adults. They are considered to be less frequent and usually appear in the absence of intra-articular lesions. However, their prevalence in asymptomatic children is unknown. We present a prospective epidemiological study of 168 asymptomatic children under 15 years of age hospitalised for various pathologies. Children with knee problems and rheumatic diseases were excluded from the study. The children were examined ultrasonographically with a 7.5 MHz linear scanner. A popliteal cyst could be identified in 4 patients. The prevalence of asymptomatic popliteal cysts was thus 2.4%. For 2 of these patients, we obtained magnetic resonance image of the knee which showed no concommitant intra-articular pathology.
Subject(s)
Popliteal Cyst/diagnostic imaging , Popliteal Cyst/epidemiology , Adolescent , Age Distribution , Child , Child, Preschool , Female , Germany/epidemiology , Humans , Male , Mass Screening/methods , Prevalence , Prospective Studies , Sex Distribution , UltrasonographyABSTRACT
UNLABELLED: An infant with an unusual clinical presentation and course of Niemann-Pick disease type C (NPC) is described. The baby presented with severe pulmonary involvement and hepatosplenomegaly at the age of 3 months and died of respiratory failure at the age of 7 months. Cell hybridization studies revealed that the infant belonged to the rare genetic complementation group 2. To our knowledge, this is the third reported case with early-lethal pulmonary involvement in NPC. All three reported patients belong to the minor complementation group 2. An elder brother of the present case had also died at 6 weeks of age from NPC with severe pulmonary involvement. The two complementation groups cannot be distinguished from each other by clinical, cellular and biochemical criteria except for severe pulmonary involvement which may be characteristic of the second group. CONCLUSION: NPC may present in early infancy with severe pulmonary involvement mimicking interstitial pneumonia. Such manifestation may be characteristic of the rare genetic complementation group 2.
Subject(s)
Lung Diseases, Interstitial/genetics , Niemann-Pick Diseases/genetics , Biopsy, Needle , Fatal Outcome , Female , Genetic Complementation Test , Humans , Infant , Lung Diseases, Interstitial/diagnostic imaging , Lung Diseases, Interstitial/pathology , Niemann-Pick Diseases/diagnostic imaging , Niemann-Pick Diseases/pathology , Radiography , Respiratory InsufficiencyABSTRACT
A new respiration system is described. The system has been developed for the therapy of very ill newborn and premature infants (RDS stage IV, gestation age less than 28 weeks, severe pneumonia etc.). The special feature of the new respiratory device is an alternating between cycles with low frequencies and relatively high amplitudes, and breathes with low amplitudes and relatively high frequencies.
