Subject(s)
Anticoagulants/therapeutic use , Neoplasms/drug therapy , Pulmonary Embolism/prevention & control , Rivaroxaban/therapeutic use , Stroke/drug therapy , Venous Thromboembolism/prevention & control , Venous Thrombosis/drug therapy , Consensus , Disease Management , Drug Administration Schedule , Drug Dosage Calculations , Humans , Neoplasms/blood , Neoplasms/complications , Neoplasms/pathology , Practice Guidelines as Topic , Pulmonary Embolism/blood , Pulmonary Embolism/complications , Pulmonary Embolism/pathology , Stroke/blood , Stroke/complications , Stroke/pathology , Venous Thromboembolism/blood , Venous Thromboembolism/complications , Venous Thromboembolism/pathology , Venous Thrombosis/blood , Venous Thrombosis/complications , Venous Thrombosis/pathologyABSTRACT
The prospective multicenter open noncomparative pharmaco-epidemiological observational project on the use of mydocalm in real clinical practice has been completed in 2013. The project has been performed in 2090 clinical/rehabilitation settings in 284 cities of 13 countries using the results of 35,383 patients. The project aimed to assess the safety of treatment (percentage of patients with adverse-effects) and pain relieving efficacy as well as patient's satisfaction with the treatment. In total, 6603 (19%) adverse-effects were recorded. Their severity was evaluated as mild in 84,48%, no serious adverse-effects were noted. The high efficacy of mydocalm in the treatment of pain syndromes with the muscle spasm has been demonstrated. The high level of tolerability and absence of the clinically significant increase of adverse effects in the combination with nonsteroidal anti-inflammatory drugs have been confirmed.
Subject(s)
Muscle Relaxants, Central/therapeutic use , Pain/drug therapy , Pain/epidemiology , Spasm/drug therapy , Spasm/epidemiology , Tolperisone/therapeutic use , Adult , Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Female , Humans , Male , Middle Aged , Muscle Relaxants, Central/adverse effects , Pain/complications , Pharmacoepidemiology , Prospective Studies , Spasm/complications , Syndrome , Tolperisone/adverse effects , Treatment OutcomeABSTRACT
Examination of chronic mercury intoxication patients in distant (post-contact) period revealed marked vision disorders and inhibited neuro-conductivity--inhibited neuronal structures of retina and optic nerve.
Subject(s)
Eye Diseases/physiopathology , Mercury Poisoning/physiopathology , Mercury/adverse effects , Occupational Diseases/chemically induced , Optic Nerve/drug effects , Retina/drug effects , Vision Disorders/chemically induced , Adult , Chronic Disease , Disease Progression , Electroretinography , Eye Diseases/diagnosis , Humans , Mercury Poisoning/diagnosis , Middle Aged , Occupational Diseases/diagnosis , Occupational Diseases/physiopathology , Ophthalmoscopy , Optic Nerve/physiopathology , Prognosis , Retina/physiopathology , Vision Disorders/diagnosis , Vision Disorders/physiopathology , Vision, Ocular/drug effectsABSTRACT
The authors described the dynamics of disorders of memory, attention and thinking in the course of treatment of patients with circulatory encephalopathy. It was shown that treatment resulted a prevailing regression of neurodynamic disorders of the higher psychic functions that was more productive at early stages of cerebrovascular insufficiency.
Subject(s)
Cerebrovascular Disorders/complications , Hypertension/complications , Intracranial Arteriosclerosis/complications , Mental Disorders/etiology , Adult , Cerebrovascular Disorders/drug therapy , Cerebrovascular Disorders/etiology , Drug Therapy, Combination , Female , Humans , Hypertension/drug therapy , Intracranial Arteriosclerosis/drug therapy , Male , Memory Disorders/diagnosis , Memory Disorders/drug therapy , Memory Disorders/etiology , Mental Disorders/diagnosis , Mental Disorders/drug therapy , Middle Aged , Neuropsychological TestsABSTRACT
On the basis of radiocardiographic and radiocirculatory examination of the central and cerebral hemodynamics in 130 patients with dyscirculatory encephalopathy (DE) caused by essential hypertension and atherosclerosis, the authors have demonstrated that the development of DE is facilitated by disturbances of the central and peripheral hemodynamics. In turn, DE reduces the function of the autoregulatory mechanisms of the cerebral blood flow and leads to insufficiency of compensatory adaptive possibilities of the cardiovascular system. It is recommended that not only cerebral disorders but also the type (hyperkinetic, hypokinetic, eukinetic) of the blood circulation in these patients be taken into consideration in selecting the optimal method of treatment.
Subject(s)
Brain Diseases/etiology , Hemodynamics , Hypertension/complications , Intracranial Arteriosclerosis/physiopathology , Brain Diseases/physiopathology , Cerebrovascular Circulation , Humans , Hypertension/physiopathology , Plethysmography, Impedance , Serum Albumin, Radio-IodinatedABSTRACT
A technique of quantitative RCG analysis is proposed and tested. It enables the unbiased evaluation of regional hemodynamics phases and of the relation between blood flow rate in arterial and venous beds. The technique is based on calculating the first derivative of the radiocirculogram. The specially developed program may be executed by the computer (ZBM EC).
