ABSTRACT
Abnormalities in Stratum Corneum (SC) in leprosy lesions have been demonstrated as evidenced by poor hydration power of SC and increased SC turn-over. In continuation of the same study morphometric studies of the SC in leprosy was undertaken as per measurement of the Thickening of the SC, Mean epidermal thickness and Basal layer: Granular layer cell ratio (B : G ratio) of the H.E. stained tissues. Further, on freshly frozen tissues the SC cell-layers were also counted. The findings suggest increased proliferative activity of the epidermis which may lead to formation of defective SC in leprosy.
Subject(s)
Epidermis/pathology , Leprosy, Borderline/pathology , Leprosy, Tuberculoid/pathology , Adolescent , Adult , Cell Division , Humans , Male , Middle AgedABSTRACT
Stratum corneum showed increased proliferative activity on the patches of leprosy as evidenced by a significantly fast stratum corneum turnover time (p 0.001) measured by fluorescent staining technic with dansyl chloride. These findings suggest imperfect keratinization on the patches of leprosy leading to formation of structurally weak stratum corneum.