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1.
Rev.Soc. Bras. Clín. Med. ; 19(4): 238-241, 2021.
Article in Portuguese | LILACS | ID: biblio-1401228

ABSTRACT

Objetivo: Avaliar a incidência e a evolução da Covid-19 em indivíduos com diagnóstico prévio de doença renal crônica estágio 5D e também comparar diabéticos e não diabéticos. Métodos: Foi analisada a mortalidade por Covid-19 em pacientes com doença renal crônica estágio 5D sem diabetes e no subgrupo de pacientes diabéticos. A comparação da idade média entre diabéticos e não diabéticos e pacientes que morreram e sobreviventes foi realizada por meio do teste t de Student para amostras independentes. A proporção de óbitos entre diabéticos e não diabéticos foi calculada pelo teste do qui-quadrado de Pearson. Resultados: A pro- porção de óbitos entre pacientes diabéticos e não diabéticos com doença renal crônica estágio 5D foi significativamente diferente (p=0,0245; razão de chance de 5,03; IC95% 1,26-21,84). A idade média foi de 55,0±15,6, e 15 pacientes (35,7%) eram diabéticos e significativamente mais velhos que os não diabéticos (p=0,0233). Não foi observada diferença na proporção de diabéticos entre homens e mulheres (p=0,5758) e nem na idade média entre diabéticos e não diabéticos (p=0,1829). Conclusão: A mortalidade por Covid-19 em pacientes com doença renal crônica estágio 5D é significativamente maior do que na população em geral, e este estudo mostrou diabetes mellitus e idade como fatores de risco adicionais para mortalidade nesta população.


Objective: To evaluate the incidence and progression of Covid-19 in individuals previously diagnosed with stage 5 chronic kidney disease and compare diabetic and nondiabetic indi- viduals. Methods: Covid-19 mortality in nondiabetic 5 chronic kidney disease patients and in the subgroup of diabetic patients was analyzed. The average age comparison between diabetic and nondiabetic patients and those who died and survived was performed using Student t test for independent samples. The proportion of deaths between diabetics and nondiabetics was calculated using Pearson's Chi-squared test. Results: The proportion of deaths between diabetic and nondiabetic 5 chronic kid- ney disease patients was significantly different (p=0.0245), odds ratio of 5.03 (95%CI= 1.26-21.84). The average age was 55.0±15.6, and 15 patients (35.7%) were diabetic and significantly older than nondiabetic (p=0.0233). No difference was observed in the proportion of diabetics between men and women (p=0.5758) or in the average age between diabetics and nondiabetics (p=0.1829). Conclusion: Covid-19 mortality in 5 chronic kidney disease patients is significantly higher than in general popula- tion and this study has shown diabetes mellitus and age as ad- ditional risk factors for mortality in this population.


Subject(s)
Humans , Diabetes Mellitus , Renal Insufficiency, Chronic , COVID-19/mortality , Risk Factors , Age Factors , Dialysis
2.
Cardiovasc Toxicol ; 12(4): 359-62, 2012 Dec.
Article in English | MEDLINE | ID: mdl-22740057

ABSTRACT

Amlodipine is a dihydropyridine calcium channel antagonist extensively used for the treatment of arterial hypertension, with predominant effect on the peripheral vascular territory. In most cases of severe intoxication, important hypotension and reflex tachycardia are usually observed. We report a case of young man with severe amlodipine intoxication that developed important bradyarrhythmias, such as low atrial rhythm, prolonged PR interval, atrioventricular block, and left bundle branch block. These rhythm disturbances suggest that, during acute intoxication, dihydropyridine loses its selective action on the vascular territory and can depress automatism and conduction of cardiac electrical stimulus.


Subject(s)
Amlodipine/poisoning , Arrhythmias, Cardiac/chemically induced , Arrhythmias, Cardiac/diagnosis , Adolescent , Arrhythmias, Cardiac/physiopathology , Electrocardiography/drug effects , Humans , Male , Time Factors
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