Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 3 de 3
Filter
Add more filters










Database
Language
Publication year range
1.
J Nerv Ment Dis ; 204(8): 620-9, 2016 08.
Article in English | MEDLINE | ID: mdl-26828911

ABSTRACT

Mobile devices, digital technologies, and web-based applications-known collectively as eHealth (electronic health)-could improve health care delivery for costly, chronic diseases such as schizophrenia. Pharmacologic and psychosocial therapies represent the primary treatment for individuals with schizophrenia; however, extensive resources are required to support adherence, facilitate continuity of care, and prevent relapse and its sequelae. This paper addresses the use of eHealth in the management of schizophrenia based on a roundtable discussion with a panel of experts, which included psychiatrists, a medical technology innovator, a mental health advocate, a family caregiver, a health policy maker, and a third-party payor. The expert panel discussed the uses, benefits, and limitations of emerging eHealth with the capability to integrate care and extend service accessibility, monitor patient status in real time, enhance medication adherence, and empower patients to take a more active role in managing their disease. In summary, to support this technological future, eHealth requires significant research regarding implementation, patient barriers, policy, and funding.


Subject(s)
Delivery of Health Care/methods , Patient Acceptance of Health Care , Schizophrenia/therapy , Telemedicine/methods , Humans
2.
Amyotroph Lateral Scler ; 7(4): 221-6, 2006 Dec.
Article in English | MEDLINE | ID: mdl-17127560

ABSTRACT

hNT cells, derived from a human teratocarcinoma cell line, are versatile neuron-like cells that have been studied as possible treatment vehicles for neurodegenerative diseases. Previously, we showed the postponement of motor deficit symptoms in a G93A mouse model of amyotrophic lateral sclerosis (ALS) by transplanting hNT cells into the lumbar spinal cord. In this study, we examined the engraftment of hNT cells at multiple sites within the lumbar spinal cord by morphological analysis of neuritic process development. Results demonstrated that cells implanted at multiple sites established neuritic processes of different lengths independent of the number of cell implants. The hNT fiber outgrowth was a maximum of 0.15-0.3 mm from the transplants and mostly spread within the gray matter; interconnections between implants were not found. Therefore, we suggest that the observed postponement of motor deficit symptoms in G93A mice was not a result of neuritic outgrowth from the implanted hNT cells.


Subject(s)
Amyotrophic Lateral Sclerosis/pathology , Amyotrophic Lateral Sclerosis/surgery , Disease Models, Animal , Nerve Regeneration , Neurons/transplantation , Spinal Cord/pathology , Spinal Cord/surgery , Amyotrophic Lateral Sclerosis/congenital , Animals , Mice , Mice, Transgenic , Neurons/pathology , Reoperation , Superoxide Dismutase/genetics , Superoxide Dismutase-1 , Survival Rate , Treatment Outcome
3.
Brain Res Dev Brain Res ; 145(1): 107-15, 2003 Oct 10.
Article in English | MEDLINE | ID: mdl-14519498

ABSTRACT

Human, neuronally committed hNT or NT2-N cells, originally derived from the Ntera2/D1 (NT2) clone after exposure to retinoic acid (RA), represent a potentially important source of cells to treat neurodegenerative diseases. Our previous in vitro experiments showed that hNT cells possess immunocytochemically detectable markers typical of dopaminergic (DA) ventral mesencephalic (VM) neurons, including tyrosine hydroxylase (TH), dopamine transporter (DAT), dopamine receptor (D2), and aldehyde dehydrogenase (AHD-2). In the current study, we sought to examine whether Nurr1, an orphan receptor of the nuclear receptor superfamily shown to be essential for the development, differentiation and survival of midbrain DA neurons, would be expressed in 3, 4, or 5 week RA-induced hNT neurons and their NT2 precursors. Our immunocytochemical analyses indicate that NT2 cells as well as hNT neurons independent of the length of RA-driven differentiation were Nurr1-immunoreactive. RT-PCR analysis confirmed the expression of Nurr1-specific mRNA in both NT2 precursors and the hNT neurons. Furthermore, immunocytochemical co-expression of Nurr1 and TH was detected in hNT neurons. The findings of this study suggest that Nurr1 may be important during the development of hNT neurons and involved in their differentiation into the dopaminergic phenotype.


Subject(s)
DNA-Binding Proteins/metabolism , Neurons/metabolism , Transcription Factors/metabolism , Blotting, Northern , Cell Count , Cell Survival , DNA-Binding Proteins/genetics , Dopamine/metabolism , Gene Expression Regulation , Humans , Immunohistochemistry , Indoles/metabolism , Neoplasms, Germ Cell and Embryonal , Nuclear Receptor Subfamily 4, Group A, Member 2 , RNA, Messenger/biosynthesis , Reverse Transcriptase Polymerase Chain Reaction , Time Factors , Transcription Factors/genetics , Tubulin/metabolism , Tumor Cells, Cultured
SELECTION OF CITATIONS
SEARCH DETAIL
...