[Evaluation of modern antibiotics efficacy at experimental Northern Asia rickettsiosis]. / Otsenka khimioterapevticheskoi éffektivnosti sovremennykh antibiotikov pri éksperimental'nom kleshchevom rikketsioze Severnoi Azii.

Comparative investigation of antibiotics therapy efficacy at experimental murine Northern Asia rickettsiosis was performed. The efficacy was evaluated by the determination of protective activity in per cent and by the pathogen erradication. The investigated antibiotics may be ranged in the following order (by the diminishing efficacy): ansamycins (azorif, rifapentine, rifampicin), tetracyclines (doxycycline), macrolides (azitromycin, sumamed), carbapenems (imipenem/cilastatin), fluoroquinolones (lomefloxacin, pefloxacin). Rifampicin and its derivatives--azorif, rifapentine, along with doxycycline and azitromycm can be recommended for clinical trials at experimental rickettsiosis profilaxy and treatment in natural infection focus.

[A new approach to the prevention and treatment of lesions caused by bacterial toxins: prospects for using inhibitors of ADP ribosylation]. / Novyi podkhod k profilaktike i lecheniiu porazhenii bakterial 'nymi toksinami: perspektivy primeneniia ingibitorov ADF-ribozilirovaniia.

The damaging action of a number of bacterial toxins is determined by their capacity for blocking the specific functions of regulatory proteins of eukaryotic cells by ADP-ribosylation. Experiments, made with the use of type B botulinic toxin and 3,N-butyrylaminobenzamide as an example, have demonstrated that specific ADP-ribosylation inhibitors are capable of making up a new group of highly active antagonists of microbial toxins.

[The effect of salmonella infection on the functional activity of the polymorphonuclear leukocytes]. / Vliianie sal'monelleznoi infektsii na funktsional'nuiu aktivnost' polimorfnoiadernykh leikotsitov.

Experiments on noninbred white mice have revealed that in the animals infected with S. moscow secondary immunodeficiency develops, which is manifested by a significant decrease in the activity of the bactericidal system of peripheral blood granular leukocytes. Simultaneously, the content of myeloperoxidase in the blood neutrophils of infected mice decreases 1.4 times and the content of lysozyme in these neutrophils decreases 2 times. Such changes are the consequence of an increase in the secretory activity of cells, occurring in the process of the development of Salmonella infection.

[Evaluation of the adhesion, colonization and enterotoxigenicity of Vibrio cholerae in the enteral infection of intact and passively immunized newborn animals]. / Ostenka adgezii, kolonizatsii i énterotoksigennosti kholernykh vibrionov pri énteral'nom zarazhenii intaktnykh i passivno immunizirovannykh novorozhdennykh zhivotnykh.

V. eltor were introduced into 323 suckling rabbits through a gastro-duodenal tube and into 629 suckling mice either by the same method, or per annum by a new specially developed technique. Passive immunization was achieved in suckling mice by the preliminary introduction of antibacterial sera into the small intestine or by feeding them with the milk of female mice immunized at the end of pregnancy, and in suckling rabbits by feeding them with the milk of goats immunized by introducing vibrios through the tests of the udder. To evaluate the results, the accumulation of liquid in the intestine and the development of diarrhea were taken into account, quantitative inoculation of homogenized intestinal matter was made; vibrios on the epithelium of the villi in the small intestine were counted and the changes of enterocytes and the lamina propria, observed in light and electron microscopy, were considered. The results of the complex quantitative evaluation in intact suckling animals revealed that the enterotoxigenicity of vibrios was manifested after their adhesion to and later colonization on the intestinal epithelium. Passive antibacterial immunization suppressed their adhesion and colonization, which resulted in protection from the enterotoxigenic effect of vibrios and their elimination from the intestine.