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Planta Med ; 75(1): 59-61, 2009 Jan.
Article in English | MEDLINE | ID: mdl-19031368

ABSTRACT

Bidens pilosa is used in folk medicine for various applications due to the presence of polyacetylenes, flavonoids, terpenoids, phenylpropanoids and others. Bioactivity-guided fractionation of different extracts of B. pilosa leaf showed potential in vitro anticancer and antimalarial activity and led to the identification of a potential marker compound, phenyl-1,3,5-heptatriyne. Erythrocyte osmotic fragility experiments revealed the various extracts as well as the marker component's toxicity profiles on normal blood cells.


Subject(s)
Alkynes/pharmacology , Antimalarials/pharmacology , Antineoplastic Agents, Phytogenic/pharmacology , Bidens/chemistry , Drugs, Chinese Herbal/pharmacology , Alkynes/chemistry , Alkynes/isolation & purification , Animals , Antimalarials/chemistry , Antimalarials/isolation & purification , Antineoplastic Agents, Phytogenic/chemistry , Antineoplastic Agents, Phytogenic/isolation & purification , Cell Line, Tumor , Drugs, Chinese Herbal/chemistry , Drugs, Chinese Herbal/isolation & purification , Erythrocytes/drug effects , Humans , Osmotic Fragility/drug effects , Plant Leaves/chemistry , Plasmodium falciparum/drug effects
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