Efficacy and cost analysis of intravenous conscious sedation for long oral surgery procedures.

The aim of this study was to determine what is considered a long oral surgery and conduct a cost-effective analysis of sedative agents used for intravenous sedation (IVS) and sedation protocols for such procedures. Pubmed and Google Scholar databases were used to identify human studies employing IVS for extractions and implant-related surgeries, between 2003 and July/2023. Sedation protocols and procedure lengths were documented. Sedative satisfaction, operator satisfaction, and sedation assessment were also recorded. Cost estimation was based on The British National Formulary (BNF). To assess bias, the Cochrane Risk of Bias tools were employed. This review identified 29 randomised control trials (RCT), six cohorts, 14 case-series, and one case-control study. The study defined long procedures with an average duration of 31.33 minutes for extractions and 79.37 minutes for implant-related surgeries. Sedative agents identified were midazolam, dexmedetomidine, propofol, and remimazolam. Cost analysis revealed midazolam as the most cost-effective option (<10 pence per procedure per patient) and propofol the most expensive option (approximately £46.39). Bias analysis indicated varying degrees of bias in the included studies. Due to diverse outcome reporting, a comparative network approach was employed and revealed benefits of using dexmedetomidine, propofol, and remimazolam over midazolam. Midazolam, dexmedetomidine, propofol, and remimazolam demonstrated safety and efficacy as sedative agents for conscious IVS in extended procedures like extractions or implant-related surgeries. While midazolam is the most cost-effective option, dexmedetomidine, propofol, and remimazolam offer subjective and clinical benefits. The relatively higher cost of propofol may impede its widespread use. Dexmedetomidine and remimazolam stand out as closely priced options, necessitating further clinical investigations for comparative efficacy assessment.

Incidents relating to paediatric regional anaesthesia in the first 8000 cases reported to webAIRS.

Regional anaesthesia is an essential tool in the armamentarium for paediatric anaesthesia. While largely safe and effective, a range of serious yet preventable adverse events can occur. Incidence and risk factors have been described, but few detailed case series exist relating to paediatric regional anaesthesia. Across Australia and New Zealand, a web-based anaesthesia incident reporting system enables voluntary reporting of detailed anaesthesia-related events in adults and children. From this database, all reports involving paediatric regional anaesthesia (age less than 17 years) were retrieved. Perioperative events and their outcomes were reviewed and analysed. When offered, the reported contributing or alleviating factors relating to the case and its management were noted. This paper provides a summary of these reports alongside an evidence review to support safe practice. Of 8000 reported incidents, 26 related to paediatric regional anaesthesia were identified. There were no deaths or reports of permanent harm. Nine reports of local anaesthetic systemic toxicity were included, seven equipment and technical issues, six errors in which regional anaesthesia made an indirect contribution and four logistical and communication issues. Most incidents involved single-shot techniques or a neuraxial approach. Common themes included variable local anaesthetic dosing, cognitive overload, inadequate preparation and communication breakdown. Neonates, infants and medically complex children were disproportionately represented, highlighting their inherent risk profile. A range of preventable incidents are reported relating to patient, systems and human factors, demonstrating several areas for improvement. Risk stratification, application of existing dosing and administration guidelines, and effective teamwork and communication are encouraged to ensure safe regional anaesthesia in the paediatric population.

A Kinematic Analysis of Wrist and Carpal Function Using Four-Dimensional Computed Tomography Technology: A Dynamic Perspective.

PURPOSE: An emerging imaging modality, four-dimensional computed tomography, can provide dynamic evaluation of carpal motion, which allows for a better understanding of how the carpals work together to achieve range of motion. The objective of this work was to examine kinematic motion of the carpus through a flexion/extension arc of motion using four-dimensional computed tomography. METHODS: A convenience sample of 20 uninjured participants underwent a four-dimensional computed tomography scanning protocol through a complete arc of flexion/extension motion. Kinematic changes in motion were quantified using helical axes motion data for each carpal. Rotation angles were compared between bones to identify differences in kinematic motion between bones. RESULTS: The bones within the proximal carpal row, the lunate, scaphoid, and triquetrum, rotate significantly to differing magnitudes at the ends of motion (40° of flexion and 40° of extension). The scaphoid rotates to the highest magnitude, followed by the triquetrum, and lastly, the lunate. The distal carpal row bones rotate to similar magnitudes throughout the entire range of motion. CONCLUSIONS: This work describes the kinematics of the carpals throughout dynamic in vivo flexion and extension. CLINICAL RELEVANCE: This study adds to an understanding of wrist mechanics and the possible clinical implications of pathological deviation from baseline kinematics.

Inadequate proximal screw fixation increases risk of failure following plate fixation of diaphyseal humerus fractures.

BACKGROUND: Operative treatment of humeral shaft fractures (AO/OTA 12) is being performed more frequently. Accordingly, it is important to understand the complications associated with plate fixation. This study analyzes risk factors associated with mechanical failure following plate fixation of humeral shaft fractures in order to further elucidate the mode and location of failure. METHODS: A retrospective review of 351 humeral shaft fractures was completed at a single level I trauma center. Eleven of eighty-five humeral shaft fractures had aseptic mechanical failure requiring revision (12.9%), following initial plate fixation. Fracture characteristics (AO type, comminution, location) and fracture fixation (plate type, multiplanar, number of screws proximal and distal to the fracture) were compared between aseptic mechanical failure and those without failure. A forward stepwise logistic regression analysis was performed to determine any significant predictors of aseptic mechanical failure. RESULTS: There was significant differences in fixation between the aseptic mechanical failure group and those without failure, specifically in the number of screws for proximal fixation (p = 0.008) and distal fixation (p = 0.040). In the aseptic mechanical failure group, patients tended to have less than < 8 cortices of proximal fixation (82%) and less than < 8 cortices of distal fixation (64%). Conversely, in patients without mechanical failure there was a tendency to have greater than > 8 cortices in both the proximal (62%) and distal fixation (70%). A forward stepwise logistic regression analysis found that less than < 8 cortices of proximal fixation was a significant predictor of aseptic failure, OR 7.96 (p = 0.011). We think this can be accounted for due to the variable bone quality, thinner cortices and multiple torsional forces in the proximal shaft that may warrant special consideration for fixation. CONCLUSION: The current dogma of humeral shaft fracture stabilization is to use a minimum of 3 screws proximal and distal to the fracture, however the current study demonstrates this is associated with higher rates of mechanical failure. In contrast, 4 bicortical screws or more of fixation on either side of the fracture had lower failure rates and may help to reduce the risk of mechanical failure. Level of Evidence Level III.

Development and validation of a national perioperative mortality risk model for pediatric surgery: The New Zealand pediatric surgical risk tool (NZRISK-pediatric): NZRISK-Pediatric.

BACKGROUND: Risk prediction models are well established as an adjunct to perioperative decision making, but few exist for pediatric surgical outcomes. The majority of risk tools do not feature Australasian data and do not estimate mortality risk beyond 30-days. Our aim was to develop and validate a model for mortality risk prediction in children (age <18yrs) at 30-days, 90-days and 1 year following all types of surgery using a national database. METHODS AND RESULTS: The New Zealand Ministry of Health National Minimum Dataset was accessed to obtain clinical and demographic data for all children having surgery between June 1st 2011 and July 1st 2016. Three quarters of the data were used to derive 3 models to predict 30-day, 90-day and 1-year mortality risk, and the remaining data used for validation. We constructed 3 models using data from 135 217 patients, validating a total of 11 covariates for risk prediction. Included were neonate, prematurity, ASA-PS status, heart and lung disease, active malignancy, sepsis, surgical type, surgical severity score, surgical urgency, ethnicity and socioeconomic deprivation. All models showed excellent discrimination (area under the receiver operating characteristic curve (AUROC) values of 0.947, 0.933 and 0.908 respectively) and calibration statistics (calibration slopes of 0.778, 1.125, 1.153, Brier scores of 0.001, 0.002, 0.003 respectively). CONCLUSION: Combining objective data with severity indices, NZRISK-Paed presents a risk stratification model which is intuitive and practical. Application of 30-day, 90-day and 1-year percentage mortality risk aids in longer-term planning, shared decision-making and allocation of resource to the individual and to high needs populations. Risk prediction tools add an objective measure to pre-operative assessment but few exist for pediatric surgery and none predict mortality beyond 30-days.

Spatial visualization ability and laparoscopic skills in novice learners: evaluating stereoscopic versus monoscopic visualizations.

Elevated spatial visualization ability (Vz) is thought to influence surgical skill acquisition and performance. Current research suggests that stereo visualization technology and its association with skill performance may confer perceptual advantages. This is of particular interest in laparoscopic skill training, where stereo visualization may confer learning advantages to novices of variant Vz. This study explored laparoscopic skill performance scores in novices with variable spatial ability utilizing stereoscopic and traditional monoscopic visualization paradigms. Utilizing the McGill Inanimate System for Teaching and Evaluating Laparoscopic Skills (MISTELS) scoring protocol it was hypothesized that individuals with high spatial visualization ability (HVz) would achieve higher overall and individual MISTELS task scores as compared to low spatial visualization ability (LVz) counterparts. Further, we also hypothesized that a difference would exist between HVz and LVz individual scores based on the viewing modality employed. No significant difference was observed between HVz and LVz individuals for MISTELS tasks scores, overall or individually under both viewing modalities, despite higher average MISTELS scores for HVz individuals. The lack of difference between scores obtained under the stereo modality suggested that the additional depth that is conferred by the stereoscopic visualization may act to enhance performance for individuals with LVz, potentially equilibrating their performance with their HVz peers. Further experimentation is required to better ascertain the effects of stereo visualization in individuals of high and low Vz, though it appears stereoscopic visualizations could serve as a prosthetic to enhance skill performance.

Application of stereoscopic visualization on surgical skill acquisition in novices.

OBJECTIVE: The use of stereoscopic imaging can provide additional depth cues that may increase trainee performance on surgical tasks, but it has yet to be evaluated using a validated surgical skill system. This study examines the influence of monoscopic vs stereoscopic visualization in novice trainees performing the McGill Inanimate System for Training and Evaluation of Laparoscopic Skill (MISTELS) tasks, a validated laparoscopic skill-evaluation system, predicting a difference in performance based on visualization modality. DESIGN: A total of 31 first- and second-year medical students at the University of Western Ontario were selected, each performed the MISTELS battery of tasks (circle cutting, peg transfer, ligated loop Placement, intracorporeal knot tying, and extracorporeal knot tying) using either monoscopic or stereoscopic visualization displays. Performance was evaluated in accordance with the MISTELS protocol. Participant visual spatial ability and manual dexterity skills were also analyzed and compared with performance. p values less than 0.05 were considered significant. RESULTS: For ligated loop placement, extracorporeal knot tying, and intracorporeal knot tying, no significant difference was found between monoscopic and stereoscopic visualization on task performance (p > 0.05). Monoscopic visualization was shown to produce significantly better performance in the peg transfer task alone (p = 0.001). Qualitatively, 57.1% of participants believed their performance was aided by stereoscopic visualization and 68.8% believed that future learners would benefit from its implementation into surgical education. Most participants rated the peg transfer task to be the least difficult task (60%) and rated the intracorporeal knot-tying task to be the most difficult (65.9%). CONCLUSIONS: These results suggest that the intrinsic difficulty of the MISTELS tasks may exceed a novice user's skill. No benefit with additional 3-dimensional cues in naïve surgical trainees was found. Additional visual cues in stereoscopic visualization may only serve to increase cognitive load and potentially decrease skill acquisition and learning.