1.
Br J Hosp Med (Lond)
; 76(6): 370, 2015 Jun.
Article
in English
| MEDLINE
| ID: mdl-26053915
Subject(s)
Adrenergic beta-Antagonists , Myocardial Ischemia/prevention & control , Preoperative Care/methods , Adrenergic beta-Antagonists/administration & dosage , Adrenergic beta-Antagonists/adverse effects , Clinical Trials as Topic , Humans , Patient Selection , Surgical Procedures, Operative/methods
2.
Clin Med (Lond)
; 14(6): 604-7, 2014 Dec.
Article
in English
| MEDLINE
| ID: mdl-25468844
ABSTRACT
Perioperative ß-blocker therapy has been advocated to reduce cardiac mortality and morbidity in high-risk cardiac patients undergoing non-cardiac surgery. Core data that supported this intervention and informed international societal guidelines has recently been withdrawn. A subsequent meta-analysis of the remaining data reporting excess mortality has re-opened the debate about the utility of ß-blocker therapy in the perioperative period. Criticism of remaining trial designs and new insights into the protective mechanisms of ß-blocker therapy in critical illness raise important questions that should now be addressed by a further robust, high-quality randomised control trial.
Subject(s)
Adrenergic beta-Antagonists , Heart Diseases , Perioperative Care , Surgical Procedures, Operative/statistics & numerical data , Adrenergic beta-Antagonists/adverse effects , Adrenergic beta-Antagonists/therapeutic use , Death , Heart Diseases/drug therapy , Heart Diseases/mortality , Humans , Perioperative Care/methods , Perioperative Care/mortality , Risk
3.
Br J Hosp Med (Lond)
; 74(12): 706, 2013 Dec.
Article
in English
| MEDLINE
| ID: mdl-24326727