ABSTRACT
Experimental studies demonstrated that hypothyroidism can lead to depressive behavior and that thyroid hormones can have antidepressant effects. Postnatal changes in local blood flow in the dorsal hippocampus and cerebellar cortex were studied in the offspring of rats kept in conditions of iodine deficiency at conception and throughout gestation. The data obtained from these studies showed that severe limitation of iodine intake before and during gestation leads to marked deficiency in the blood supply to both of these brain structures, though the decrease in local blood flow in the dorsal hippocampus was more marked. Addition of iodine to the diet of females prevented this deficit of blood flow in both structures.
Subject(s)
Cerebellar Cortex/blood supply , Cerebrovascular Circulation/physiology , Hippocampus/blood supply , Iodine/deficiency , Prenatal Exposure Delayed Effects , Animal Feed , Animals , Cerebellar Cortex/growth & development , Cerebellar Cortex/metabolism , Female , Hippocampus/growth & development , Hippocampus/metabolism , Iodine/metabolism , Maternal-Fetal Exchange , Neurons/metabolism , Pregnancy , Rats , Receptors, Thyroid Hormone/metabolism , Thyroid Hormones/physiology , Trace Elements/deficiency , Trace Elements/metabolismABSTRACT
Studies on white rats showed that intraperitoneal administration of small doses of fentanyl (0.005 mg/kg) and morphine (1 mg/kg) decreased local blood flow and increased partial pressure of oxygen (pO2) in the frontoparietal area of the cerebral cortex but had the opposite effects in the nucleus accumbens--where there was a significant increase in local blood flow and just as significant a decrease in pO2. Analysis of the data led to the conclusion that these changes must result from significant changes in functional-metabolic activity in these structures, induced by intraperitoneal administration of fentanyl or morphine.
