1.
Bioorg Med Chem Lett
; 16(19): 5207-11, 2006 Oct 01.
Article
in English
| MEDLINE
| ID: mdl-16870427
ABSTRACT
A novel series of substituted quinoline analogs were designed and synthesized as potent and selective melanin concentrating hormone (MCH) antagonists. These analogs show potent (nM) activity (12a-k) with a moderate selectivity. Conversely, the conformationally constrained thienopyrimidinone analogs (18a-g) showed improved activity in MCH-1R and selectivity over 5HT2C.