ABSTRACT
This study used a randomized control group design to investigate the impact of an assistive technology and home modification intervention on function for individuals who are aging with a disability. There were 91 participants with polio, rheumatoid arthritis, cerebral palsy, spinal cord injury, stroke, and other impairments. Outcome data were collected at 12 and 24 months through in-home interviews using the Older Americans Resources and Services Instrument (OARS) and the Functional Independence Measure (FIM), and through monthly telephone contact on the hours of in-home care, hospitalizations, and acquisition of AT. The treatment group received an in-home evaluation of their equipment and home modification needs. All recommended AT and home modifications were provided and paid for in full or in part by the study. The control group received the standard community-available health care. A significant "group by time" interaction for the FIM suggested a slower decline in function for the treatment group over 2 years. Further analyses found that the treatment group was more likely to use equipment to maintain independence vs. personal assistance. This study supports the value of assistive technology for adults aging with a disability and suggests that it be provided earlier in the aging process.
Subject(s)
Aging , Disabled Persons/rehabilitation , Self-Help Devices , Activities of Daily Living , Adult , Age Factors , Aged , Aged, 80 and over , Arthritis, Rheumatoid/physiopathology , Arthritis, Rheumatoid/rehabilitation , Cerebral Palsy/physiopathology , Cerebral Palsy/rehabilitation , Female , Health Status Indicators , Humans , Male , Middle Aged , Poliomyelitis/physiopathology , Poliomyelitis/rehabilitation , Spinal Cord Injuries/physiopathology , Spinal Cord Injuries/rehabilitation , Stroke/physiopathology , Stroke RehabilitationABSTRACT
[structure: see text] Brasilibactin A, a naturally occurring siderophore related to the mycobactins, has been synthesized in six steps. Use of asymmetric titanium-mediated aldol reactions allowed the preparation of both diastereomers from a common synthetic intermediate, thus allowing the relative stereochemistry of the natural product to be assigned. Brasilibactin A exhibits no inhibition of histone deacetylases (HDACs) in spite of the N-formyl-N-hydroxy lysine moiety that is expected to affect the activity of these metal-dependent lysine-modifying enzymes.
Subject(s)
Enzyme Inhibitors/chemical synthesis , Stearic Acids/chemical synthesis , Amides/chemistry , Enzyme Inhibitors/chemistry , Histone Deacetylase Inhibitors , Histone Deacetylases/metabolism , Histones/chemistry , Hydroxylation , Lysine/chemistry , Metals/chemistry , Molecular Structure , Oxazoles/chemistry , Stearic Acids/chemistry , Stereoisomerism , Thiazolidines/chemistryABSTRACT
An efficient synthesis of the lactam core of pseurotin A has been accomplished. Key features of this synthesis include a tandem oxidation-cyclization to form the lactam from an acetylenic amide precursor. Although coupling of a lactam aldehyde with an appropriate side chain was not effective, it is anticipated that incorporating a partial side chain at an earlier stage should permit completion of the total synthesis of pseurotin A.