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2.
J Urol ; 165(6 Pt 2): 2394-8, 2001 Jun.
Article in English | MEDLINE | ID: mdl-11371985

ABSTRACT

PURPOSE: We review our initial cases of continent cystostomy to assess long-term functional results and complications after a minimum of 15 years of followup. MATERIALS AND METHODS: Between 1976 and 1984, 23 continent cystostomies were performed on 15 boys and 8 girls with neuropathic bladders. Mean patient age at surgery was 8 years and 4 months (range 3 to 16) and mean followup was 20 years (range 15 to 23). The neurological lesions were due to 21 myelomeningocele (2 associated with an imperforated anus in 21 cases), spinal neuroblastoma in 1 and complex genitourinary malformation associated with an imperforated anus in 1. Closure of the bladder neck was performed in 21 cases (16 during the same procedure, 5 secondarily) and 2 did not undergo this procedure. The appendix was used as the catheterizable conduit in 20 cases, 1 ureter in 2 and a bladder tube in 1. Bladder augmentation was performed during the same procedure in 2 cases and at a later stage in 8. Five patients presented with unilateral or bilateral secondary vesicoureteral reflux. RESULTS: One death occurred after conversion to cutaneous diversion due to a postoperative infection leading to a ventriculoperitoneal valve infection. The remaining 22 patients were followed every 6 to 12 months. No metabolic disorder, secondary malignancy or spontaneous bladder perforation was noted. Bilateral upper tract deterioration was found in 10 cases leading to secondary bladder augmentation by enterocystoplasty in 6 and creation of noncontinent diversion in 4. Leakage occurred after bladder neck closure in 5 patients. Bladder stones were found in 5 patients (2 had prior bladder augmentation). Complications related to the conduit included stomal stenosis or persistent leakage in 11 cases, which required surgical revision and/or repeated dilations and 1 noncontinent diversion after revision failure. Five patients presented with intestinal occlusion due to volvulus in 3 and adhesion in 2. We noted that after 10 years of followup complications were rare and concerned mostly the catheterizable conduit. Therefore, 16 patients had a good and stable result while 6 have noncontinent diversion. CONCLUSIONS: The rate of complications has a tendency to decrease with time. The results obtained in this series may appear less satisfactory than those of more recent series, which may be due to the fact that these oldest continent cystostomies correspond to acquisition of experience of this novel approach, and to a period when the concept of low pressure reservoir was not yet established and bladder augmentations were not routinely performed. Since 1984 no continent cystostomy performed at our institution was converted into a noncontinent diversion. This series with long followup demonstrates that continent cystostomy is a procedure with lasting efficiency.


Subject(s)
Cystostomy , Urinary Bladder, Neurogenic/surgery , Urinary Incontinence/surgery , Adolescent , Child , Child, Preschool , Cystostomy/adverse effects , Cystostomy/methods , Female , Humans , Male , Meningocele/complications , Retrospective Studies
3.
Eur J Obstet Gynecol Reprod Biol ; 94(2): 296-300, 2001 Feb.
Article in English | MEDLINE | ID: mdl-11165742

ABSTRACT

The authors report three cases of pregnancy in women treated for bladder exstrophy. Based on a review of the literature, and the follow-up of these cases, the aim of this study was to determine the prognosis of pregnancy, which is currently possible due to the progress in antibiotherapy and surgery. Nevertheless, these pregnancies need to be carefully followed-up, not only because of the complications that may occur to the mother and the infant, but also because of the type of delivery involved.


Subject(s)
Bladder Exstrophy/complications , Bladder Exstrophy/surgery , Pregnancy Complications , Cesarean Section , Female , Humans , Infant, Newborn , Infertility, Female/etiology , Pregnancy , Pregnancy Outcome
4.
Eur Urol ; 38(5): 627-30, 2000 Nov.
Article in English | MEDLINE | ID: mdl-11096248

ABSTRACT

OBJECTIVE: The aim of this study was to evaluate the usefulness of investigating underlying urinary tract pathology after the first episode of acute epididymitis in children with no prior urological history, and also to assess the possible predictive factors of urological disease at the time of diagnosis. METHODS: Children with acute epididymitis were studied retrospectively over a period of 8 years. Diagnosis was made either using ultrasonography or surgical exploration. Renal ultrasonography and voiding cystourethrography were performed 1 month after epididymitis. RESULTS: These tests were carried out in 38 children who revealed 7 anomalies (18%). Only 1 patient received further surgery : endoscopic treatment of a ureterocele. We also studied 3 predictive factors: age <2 years; recurrence, and urine bacteria. None could be associated with the presence of urinary tract pathology. CONCLUSION: The authors suggest that, when there is no previous urological anomaly and absence of bacteriuria, routine screening for epididymitis should be carried out following the second episode.


Subject(s)
Epididymitis/diagnosis , Acute Disease , Adolescent , Child , Child, Preschool , Humans , Infant , Male , Retrospective Studies
5.
Ann Urol (Paris) ; 34(4): 228-31, 2000 Aug.
Article in French | MEDLINE | ID: mdl-10994140

ABSTRACT

Enterocystoplasty complications related to the presence of intestinal mucous presence in the bladder are well known and well reported in the literature. Mechanical problems in the intestinal tract due to using gut for bladder augmentation are not as well recognised. We analyzed three cases of children treated by ileocystoplasty who presented an intestinal volvulus in two cases and a cecal volvulus in one case around the vascular pedicle of the intestinal patch used for bladder augmentation.


Subject(s)
Intestinal Obstruction/etiology , Plastic Surgery Procedures/adverse effects , Urinary Bladder/surgery , Urogenital Surgical Procedures/adverse effects , Adolescent , Child , Female , Humans , Male , Postoperative Complications
6.
Eur Urol ; 38(1): 96-9, 2000 Jul.
Article in English | MEDLINE | ID: mdl-10859449

ABSTRACT

Stenosing and calcified ureteritis occurring in Henoch-Schönlein purpura remains a rare urological complication. The authors describe their own experience of the diagnosis and treatment of this rare pathology along with a review of the literature. Recognition and early surgical management may prevent serious renal outcome. In cases of ureteral replacement, different procedures using ileal segment have been proposed. We report the results of the Cockett and Goodwin procedure with a follow-up of more than 25 years.


Subject(s)
IgA Vasculitis/complications , Ileum/transplantation , Ureteral Obstruction/surgery , Child , Constriction, Pathologic , Follow-Up Studies , Humans , Inflammation/complications , Inflammation/etiology , Ureteral Diseases/complications , Ureteral Diseases/etiology , Ureteral Obstruction/etiology , Ureteral Obstruction/pathology
7.
J Urol ; 164(1): 145-8, 2000 Jul.
Article in English | MEDLINE | ID: mdl-10840448

ABSTRACT

PURPOSE: Temporary high diversion for posterior urethral valves remains controversial. Even in the most severe cases some physicians deny the efficacy of this treatment. They assert that high diversion does not change the outcome of kidney function and has an iatrogenic, deleterious effect on the bladder. We believe that these 2 assertions may be inaccurate. MATERIALS AND METHODS: We evaluated 17 of 120 boys with posterior urethral valves who underwent temporary high diversion via Sober-en-T ureterostomy. This procedure immediately decompresses the upper urinary tract and leaves the bladder functional. Mean duration of diversion was 13 months. Bladder function results were good and diversion clearly had no deleterious effect. However, our series was too small to conclude with certainty that renal function improved due to diversion and not to valve resection only. Rapid improvement in creatinine was noted in all cases after diversion. RESULTS: In this study we reviewed opposing opinions. It appears clearly evident that physicians who believe that ureterostomy creates a valve bladder are considering only loop diversion, which temporarily defunctionalizes the bladder. On the contrary, Sober-en-T diversion preserves bladder cycling. In addition, those who report poor kidney function after high diversion fail to mention that this procedure is usually performed only in the most severe cases. CONCLUSIONS: For severe cases of posterior urethral valves one should not hesitate to create temporary high diversion, which may possibly improve renal function. Sober-en-T ureterostomy does not damage the bladder.


Subject(s)
Postoperative Complications/epidemiology , Urethra/abnormalities , Urethra/surgery , Urinary Diversion/adverse effects , Urinary Diversion/methods , Child , Humans , Male , Time Factors
8.
Eur J Pediatr Surg ; 10(1): 30-4, 2000 Feb.
Article in English | MEDLINE | ID: mdl-10770244

ABSTRACT

BACKGROUND/PURPOSE: Bladder augmentation for small vesical capacity represents an important aid to these patients, but the appearance of complications is not rare. We analysed the complications of the enterocystoplasty techniques used in our Department. METHODS: From 1983 to 1997 sixteen girls and fourteen boys were treated. We performed 28 bladder augmentations (in 13 cases using small bowel, in one case using ileum and caecum and in 14 cases using sigmoid colon) and 2 bladder substitutions (in one case with ileum and sigmoid colon and in the second using a colonic segment). RESULTS: Twelve children present recurrent urinary infections. In five children bladder stones were formed (among them a case of familial cystinuria-lysinuria). Two children presented intestinal volvulus and another one a caecal volvulus. In two children a perforation of the augmented bladder was treated operatively. An 11-years-old child presented severe electrolyte disturbances. CONCLUSIONS: The complications presented in our patients confirm the view that they are associated with intestinal mucosa in the bladder and our study proves, once more, the current necessity to seek alternative tissues for bladder augmentation.


Subject(s)
Intestine, Small/surgery , Urinary Bladder, Neurogenic/surgery , Urinary Bladder/surgery , Urologic Surgical Procedures/adverse effects , Adolescent , Child , Female , Humans , Intestinal Obstruction/etiology , Male , Recurrence , Ureter/surgery , Urinary Bladder Calculi/etiology , Urinary Tract Infections/etiology
9.
Eur J Pediatr Surg ; 10(1): 72-6, 2000 Feb.
Article in English | MEDLINE | ID: mdl-10770254

ABSTRACT

The authors report four cases of arterial priapism in the child, a rare condition since only 13 cases are described in the literature. High-flow priapism follows perineal or penile injury with damage to a cavernosal artery and formation of an arteriosinusoidal fistula. The onset may be immediate but more often occurs after a few days. Arterial priapism is painless, as the corpora cavernosa are less tumescent in the anterior third of the penis. The clinical appearance and circumstances of onset suggest the diagnosis. Doppler ultrasound is the complementary investigation of choice, confirming and localising the fistula. Various methods of treatment have been proposed. Injections of alphastimulant seem ineffective in most cases and are not without danger. Surgery, which is potentially damaging, has been used only in the adult. Most authors propose embolising with resorbable material the artery which feeds the fistula. However, priapism may resolve spontaneously in less than three weeks, as occurred in our cases, without recurrence or subsequent erectile dysfunction. We thus consider the condition may initially be managed by observation alone, with recourse to embolisation if priapism does not resolve after a period of time which however remains to be defined.


Subject(s)
Penis/injuries , Priapism/etiology , Arteries/injuries , Child , Humans , Male , Penis/blood supply
10.
Arthritis Rheum ; 43(1): 109-19, 2000 Jan.
Article in English | MEDLINE | ID: mdl-10643706

ABSTRACT

OBJECTIVE: To retrospectively assess, with a sufficiently long followup (mean 11.6 years; median 9 years), the long-term outcome of chronic recurrent multifocal osteitis (CRMO), a multifocal, inflammatory bone disease. METHODS: Patients included were 8 children/adolescents and 7 adults with no family history of rheumatic disease who had been diagnosed as having CRMO between 1979 and 1995. Ten patients had undergone at least 1 bone biopsy of the lesions, with histologic examination and multiple cultures. In 1996, in addition to an in-depth interview, 12 patients underwent an extensive physical examination, laboratory evaluation, HLA-A, B, C, and DR typing, bone radiography and scintigraphy, and computed tomography scan of the sternoclavicular and sacroiliac joints. RESULTS: Remission was observed in 3 patients. The other 12 patients developed various associations of vertebral (n = 10), sacroiliac (n = 6), anterior thoracic (n = 7), peripheral articular (n = 2), enthesopathic (n = 4), or dermatologic (palmoplantar pustulosis in 3 cases and psoriasis in 2) involvements. Spine involvement was the most common and occurred the earliest (median time to appearance after the onset of osteitis 5.63 years). Clinical sacroiliitis was always unilateral. No patients carried the HLA-B27 haplotype. CRMO responded well to nonsteroidal antiinflammatory drugs. Twelve patients met the European Spondylarthropathy Study Group criteria for spondylarthopathy. CONCLUSION: After 10 years, CRMO had usually evolved to spondylarthropathy, but with certain features not usually seen in the latter: predominantly, unilateral sacroiliitis, no familial form, and no link with HLA-B27.


Subject(s)
Osteitis/pathology , Sacroiliac Joint/pathology , Spondylitis/pathology , Thoracic Vertebrae/pathology , Acute Disease , Adolescent , Adult , Age of Onset , Anti-Inflammatory Agents, Non-Steroidal/administration & dosage , Child , Chronic Disease , Disease Progression , Europe , Family Health , Female , Follow-Up Studies , Humans , Male , Middle Aged , Osteitis/diagnostic imaging , Osteitis/drug therapy , Recurrence , Retrospective Studies , Spondylitis/diagnostic imaging , Spondylitis/drug therapy , Tomography, X-Ray Computed
11.
BJU Int ; 84(9): 1054-7, 1999 Dec.
Article in English | MEDLINE | ID: mdl-10571635

ABSTRACT

OBJECTIVE: To report our experience of assessing children with chronic voiding dysfunction (>6 months' duration) using a minimal urodynamic evaluation, and the management of detrusor-sphincter dyscoordination (DSdc) using pelvic floor biofeedback. PATIENTS AND METHODS: From 1994 to 1997, 120 children (mean age 7.5 years) with three predominant and associated symptoms were referred to one urologist; they had nocturnal enuresis (28 children), urge incontinence (42) or urinary tract infection (50). All patients were assessed by urinary culture, renal ultrasonography and a minimal urodynamic evaluation, i.e. urinary flowmetry with sphincter electromyography (EMG) using perineal surface electrodes. If they had urinary tract infection and/or renal dilatation, they underwent voiding cysto-urethrography. In children with DSdc, urinary training with frequent voiding was instituted initially, with subsequent pelvic floor biofeedback exercises if the improvement was deemed unsatisfactory. RESULTS: DSdc was diagnosed in 33 children (28%), none of whom had isolated nocturnal enuresis. Pelvic floor biofeedback was undertaken by 15 children (12 girls and three boys); it was well accepted because it was administered as a computer game. In all affected patients the DSdc resolved on EMG and there was a significant clinical improvement. Vesico-ureteric reflux was detected in 24 patients, associated with DSdc in 10. The reflux resolved spontaneously on antibiotic prophylaxis in six children and after urinary re-education in four. CONCLUSION: A minimal urodynamic evaluation seems to be useful in the diagnosis of DSdc which caused urinary tract infection and/or bladder overactivity. The results with pelvic floor biofeedback were excellent in these children.


Subject(s)
Biofeedback, Psychology/methods , Urination Disorders/rehabilitation , Urodynamics , Child , Child, Preschool , Chronic Disease , Female , Humans , Male , Pelvic Floor , Retrospective Studies , Urination Disorders/physiopathology , Vesico-Ureteral Reflux/etiology , Vesico-Ureteral Reflux/physiopathology
12.
Pediatr Radiol ; 29(10): 742-7, 1999 Oct.
Article in English | MEDLINE | ID: mdl-10525781

ABSTRACT

BACKGROUND: In at least 15 % of dilated urinary tracts, diuresis renography fails to assess the presence or absence of urinary obstruction. OBJECTIVE: To determine the shortcomings of (99 m)Tc-DTPA frusemide diuresis renography by reference to pressure flow studies. MATERIALS AND METHODS: Thirty-four patients, aged 1 month to 20 years, with questionable obstruction were evaluated by diuresis renography and pressure flow studies (the Whitaker test) as the reference method during the same short period of time. Discrepancies were analysed. RESULTS: In patients with type I or IIIa renographic response, pressure flow studies never led to any change in management. Poor function, major dilatation and prior surgery were found to be risk factors of inaccurately obstructive pattern (type II) on renography (n = 6). In patients with type IIIb response, pressure flow studies could show low-grade (n = 3) or intermittent obstruction (n = 2). Intermittent obstruction was also demonstrated in two patients with type II response. CONCLUSION: In patients with risk factors, type II response was sometimes inaccurate, and urodynamic evaluation showed absence of obstruction and led to conservative management. Type IIIb response should be considered equivocal rather than partially obstructive, and pressure flow studies could be considered in such patients.


Subject(s)
Radioisotope Renography , Urologic Diseases/diagnostic imaging , Adolescent , Adult , Child , Child, Preschool , Diuresis , Diuretics , Female , Furosemide , Humans , Infant , Infant, Newborn , Male , Pressure , Radiopharmaceuticals , Technetium Tc 99m Pentetate
13.
Ann Pathol ; 19(1): 26-9, 1999 Mar.
Article in French | MEDLINE | ID: mdl-10320908

ABSTRACT

Two observations of extrarenal nephrogenic nodule in inguinal canal are reported. We underline the difficulties in differential diagnostic with true Wilms' tumor, and in sparing these pediatric cases from more aggressive treatment. The main morphological arguments in favor of non-tumoral nephrogenic nodular remnants are: the size of the lesion, the association with a congenital inguinal hernia suggesting a congenital abnormality, and the organoid organization of blastemic tissue surrounding the cavities lined with "hobnail" epithelium evoking a mesonephrogenic origin.


Subject(s)
Abdominal Neoplasms/pathology , Inguinal Canal/pathology , Wilms Tumor/pathology , Choristoma/pathology , Diagnosis, Differential , Female , Humans , Infant, Newborn , Kidney Diseases/pathology
14.
BJU Int ; 83(6): 658-61, 1999 Apr.
Article in English | MEDLINE | ID: mdl-10233575

ABSTRACT

OBJECTIVE: To evaluate whether contralateral meatal advancement based on the technique described by Gil Vernet decreases the risk of postoperative contralateral reflux, which may occur after a unilateral reimplantation. PATIENTS AND METHODS: From January 1986 to 1997, 321 reimplantations were performed for unilateral vesico-ureteric reflux (VUR) using the Cohen procedure. In cases where the contralateral meatus was symmetrical or had a pathological appearance, preventive contralateral surgery with meatal advancement was performed. RESULTS: Ureteric reimplantation was exclusively performed unilaterally in 254 patients and in 67 a contralateral meatal advancement was performed. There were 29 cases of contralateral reflux at the 4-month follow-up. In nine patients contralateral reimplantation was necessary for persistent symptomatic VUR, the reflux resolved spontaneously in 14 and a radiological examination was necessary in six. Reflux also appeared on the Gil Vernet side in only 6% of patients; there were no clinical symptoms and the outcome was favourable. CONCLUSION: The advancement of the meatus using the Gil Vernet procedure is simple, with no surgical complications. We suggest that this technique constitutes a useful surgical alternative in the prevention of contralateral reflux.


Subject(s)
Postoperative Complications/prevention & control , Vesico-Ureteral Reflux/prevention & control , Vesico-Ureteral Reflux/surgery , Child , Follow-Up Studies , Humans , Reoperation
15.
Prog Urol ; 8(2): 254-7, 1998 Apr.
Article in French | MEDLINE | ID: mdl-9615937

ABSTRACT

Ureteric polyp is a benign lesion, and an uncommon cause of hydronephrosis in children. It is associated with intermittent lumbar pain and haematuria. The diagnosis is usually based on intravenous urography or retrograde urography. Treatment must be conservative and consists of simple resection of the polyp, associated with varying degrees of ureteric resection depending on the size of the lesion. No case of recurrence after treatment has been reported to date. The authors report a case in a 7-year-old boy and present a review of the literature.


Subject(s)
Polyps/diagnosis , Ureteral Neoplasms/diagnosis , Child , Follow-Up Studies , Hematuria/etiology , Humans , Hydronephrosis/etiology , Low Back Pain/etiology , Male , Neoplasm Recurrence, Local , Polyps/complications , Polyps/surgery , Ureteral Neoplasms/complications , Ureteral Neoplasms/surgery , Urography
16.
Prog Urol ; 8(1): 78-82, 1998 Feb.
Article in French | MEDLINE | ID: mdl-9533156

ABSTRACT

OBJECTIVES: Laparoscopy now constitutes the reference technique for the diagnosis and treatment of cryptorchid testes. We report our experience over the last three years (1993-1996). MATERIAL AND METHODS: 48 strictly impalable testes were investigated in 46 boys between the ages of 11 months and 14.5 years (mean age: 40 months). The intraperitoneal investigation assessed both deep inguinal regions looking for gonads, vas deferens and pedicles. Intra-abdominal gonads were ligated and their pedicle was sectioned laparoscopically allowing transinguinal descent 6 months later according to the Fowler-Stephens technique. RESULTS: We found 21 cases of typical antenatal torsion, including one bilateral case (pedicle and vas deferens present, but gonad absent), one case of total unilateral agenesis and 3 cases of incomplete agenesis (only the vas deferens was detected) and performed three resections of the gonadal rest for histological examination. The first-stage of cryptorchid testis descent was performed in 20 cases, by laparoscopy in 19 cases (1 failure of insufflation). Definitive descent was possible in 13 cases, with early onset of atrophy in only one case. CONCLUSION: Laparoscopy is therefore a simple technique, allowing a definitive diagnosis and two-stage descent without increasing the risk of testicular atrophy.


Subject(s)
Cryptorchidism/diagnosis , Laparoscopy , Adolescent , Atrophy , Child , Child, Preschool , Cryptorchidism/surgery , Gonadal Dysgenesis/diagnosis , Gonadal Dysgenesis/surgery , Humans , Infant , Inguinal Canal/pathology , Insufflation/adverse effects , Laparoscopy/adverse effects , Ligation , Male , Peritoneum/pathology , Risk Factors , Spermatic Cord/pathology , Spermatic Cord Torsion/diagnosis , Spermatic Cord Torsion/surgery , Testis/abnormalities , Testis/pathology , Treatment Outcome , Vas Deferens/pathology
17.
J Urol ; 159(3): 1006-9, 1998 Mar.
Article in English | MEDLINE | ID: mdl-9474217

ABSTRACT

PURPOSE: We report a series of 35 neonates presenting with ureterocele diagnosed during the antenatal period or during the first weeks of life. The first line treatment was an endoscopic incision. MATERIALS AND METHODS: Immediate postnatal evaluations detected 37 ureteroceles (bilateral in 2 cases), including 16 of the intravesical type and 21 that were ectopic. Endoscopic incision permitted decompression of the majority of ureteroceles and improvement in renal function in most cases. Secondary low grade vesicoureteral reflux appeared in 9 neonates (ectopic in 8 cases) and had already been present in 14 patients. RESULTS: Endoscopic treatment alone proved effective in 14 of the intravesical ureteroceles, while the other 2 cases requiring upper pole nephrectomy (1) and ureterovesical reimplantation using the Cohen technique (1). In contrast, among patients with the ectopic form additional surgery was necessary in 18 cases. Treatment comprised resection of the ureterocele with bladder reconstruction and ureteral reimplantation without remodeling according to the Cohen technique in 15 cases, total ureteronephrectomy in 1 and pole nephrectomy in 2. CONCLUSIONS: We suggest that early endoscopic incision be used for first line treatment of ureteroceles. The aim of this procedure is to ensure better urine drainage, preserve function of the parenchyma and reduce the risk of severe infection in the neonate. The principal complication remains secondary vesicoureteral reflux onset, which can be controlled well by antibiotic prophylaxis but requires regular radiological monitoring.


Subject(s)
Endoscopy , Ureterocele/surgery , Female , Humans , Infant, Newborn , Male , Nephrectomy , Retrospective Studies , Ureterocele/diagnosis
18.
Eur J Pediatr Surg ; 7(5): 292-5, 1997 Oct.
Article in English | MEDLINE | ID: mdl-9402489

ABSTRACT

The buried penis is a rare congenital entity, whose treatment is surgical. There are few publications concerning this matter. The authors report on their experience in 10 cases (1990-1995). In this abnormality, the tip of the glans does not project from the pubic or scrotal skin. It is due to: 1) an excessive development of the penile fascia which retracts the penis; 2) insufficient attachment of the penile skin at the base of the penis; 3) often excessive prepubic fat worsens the appearance of the abnormality but does not by itself totally explain it; 4) a tight phimosis is often present. Surgical treatment is necessary because this aspect tends to persist even after puberty. One cannot indeed count on the development at the age of puberty, neither on the diminution of the fat, nor on the simple cure of the phimosis. One must above all ban circumcision which causes the risk of eliminating the skin necessary for reconstruction. The surgical procedure will comprise: 1) a longitudinal dorsal incision extended circumferentially; 2) resection of the thickened fascia penis; 3) anchoring of the deep face of the dermis to the proximal part of the fascia penis at the base of the penis. This surgical procedure has always brought a significant improvement to the appearance of the penis.


Subject(s)
Penis/abnormalities , Penis/surgery , Plastic Surgery Procedures/methods , Child , Child, Preschool , Humans , Infant , Male
20.
Ann Urol (Paris) ; 31(2): 92-6, 1997.
Article in French | MEDLINE | ID: mdl-9245255

ABSTRACT

A prospective bacteriological study in 50 children with acute pyelonephritis (APN) (32 girls and 18 boys) and 132 children with lower urinary tract infections (LUTI) (89 girls and 43 boys) was conducted from May to December 1993. Infection was defined by Kass' criteria and APN was defined by the clinical findings. C-Reactive Protein (CRP) assay and postcontrast computed tomography in the presence of a doubt concerning the diagnosis. Escherichia coli (EC) was the bacterial species most frequently isolated (76%). A systematic search for fimbriae protein adhesins (group PAP: pyelonephritis associated pil) on the EC was performed by haemagglutination (human group A red blood cells). 64% of EC possessed fimbriae protein adhesions in the APN group versus only 20% in the LUTI group. In children in whom an organic abnormality was demonstrated, the incidence of fimbriae protein-positive EC was 33% while in children with no organic abnormality, particularly without reflux, 89% of EC presented fimbriae protein. A statistically significant difference was demonstrated between these two groups (p < 0.01). The results of this study illustrate the important role of these adhesins in the development of APN. These adhesins facilitate countercurrent ascension of bacteria in the ureter towards the upper urinary tract and can make the bacteria resistant to certain antibiotics. Testing for fimbriae protein can be useful in clinical practice when investigating the aetiology of APN in the absence of demonstrated reflux. A latex test should soon be available to facilitate the detection of fimbriae protein.


Subject(s)
Adhesins, Bacterial/analysis , Pyelonephritis/microbiology , Acute Disease , Adhesins, Escherichia coli/analysis , Adolescent , Anti-Bacterial Agents/pharmacology , Child , Child, Preschool , Data Interpretation, Statistical , Escherichia coli/drug effects , Escherichia coli/isolation & purification , Female , Hemagglutination Tests , Humans , Infant , Male , Microbial Sensitivity Tests , Prospective Studies , Urinary Tract Infections/microbiology
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