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4.
Farmakol Toksikol ; 49(5): 74-6, 1986.
Article in Russian | MEDLINE | ID: mdl-3770181

ABSTRACT

It was found that a hypotensive effect of penbutolol used for treatment of 234 patients with hypertensive disease exceeded that of propranolol and developed at a dose of 20-80 mg a day at the end of the 2nd week of treatment. Penbutolol produces a less negative chronotropic effect as compared to propranolol. The excess of penbutolol therapeutic dose leads to the further augmentation of a positive clinical effect.


Subject(s)
Hypertension/drug therapy , Penbutolol/therapeutic use , Propanolamines/therapeutic use , Adult , Aged , Drug Evaluation , Female , Hemodynamics/drug effects , Humans , Hypertension/physiopathology , Male , Middle Aged , Propranolol/therapeutic use , Random Allocation
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