[Total pelvic exenteration in the treatment of advanced pelvic cancer]. / Exenteratia pelvina totala in tratamentul cancerului pelvin avansat.

Total pelvic exenteration (TPE) is a radical and aggressive procedure performed in the local advanced pelvic cancer started from any pelvic organ. The experience of 73 TPE performed for local invasive cancer and centro-pelvic recurrences with initial malignancy at the cervix (45 cases), rectum (19 cases), vagina (5 cases), endometrial (3 cases) and urinary bladder (1 case), in 61 females and 12 males with age range 27-78 years, are analysed. The procedures were performed for advanced pelvic cancer in 24 cases and also for invasive centro-pelvic recurrences in 49 cases (67.5%). In 5 cases, TPE was extended laterally. In 42 patients reconstructive procedures were added. All patients survived to surgery but 5 postoperative deaths (6.8%) were recorded. Complications occurred in 52% of cases, 38 from 73 patients had one or more than one complication with an average of 1.5 per patient. 22 among these patients (30%) requiring operative treatment. The average survival was 49.07 months, the median survival of 55 months and the estimated survival at 11 and 78 months was 66%, respectively 50%. The procedure is indicated in the absence of pelvic wall invasion and secondary distant dissemination and lengthens significantly the life span and increase the quality of life.

[Retinoschisis--the clinical associations and therapeutic possibilities]. / Retinoschizis--asocieri clinice si posibilitati terapeutice.

Retinoschisis is a vitreo retinal dystrophy characterized by splitting of the neuroretinal layers. The paper presents two cases of retinoschisis associated with retinal detachment. As a particularity, one patient was diagnosed with von Willebrand disease and the other one, with otomandibular dysostosis (Francois-Haustrade). There are presented therapeutical methods used in this two cases: Laser, Argon photocoagulation, transscleral cryopexia, scleral buckling and also the functional and anatomical results.

[The effects of the drug Mirtilene Sifi on retinal sensitivity in healthy subjects]. / Efectele medicamentului Mirtelene Sifi asupra sensibilitatii retiniene la subiectii sanatosi.

Our study involve 15 normal ophthalmological subjects, when take 4 doses a day of Mirtelene Sifi for 15 days. The assessment of the efficiency of this drug on visual performances was made by comparison of the results (before and after the administration) obtained by testing the retinal sensibility (threshold central 30-2, Humphrey visual field analyzer) and the adaptation ability to dark of the retina. The results show the real efficiency of the drug on both the parameters.

[Drug therapy regimens in diabetic retinopathy]. / Scheme terapeutice medicamentoase în retinopatia diabetica.

Diabetes mellitus constitutes the fourth cause of general mortality and diabetic retinopathy, one of the most important cause of blindness. The paper shows the necessity and the possibilities of the most precocious treatment of diabetic retinopathy, depending of the complex pathogenesis of the disease, as well as the necessity of the new clinical and pharmacological trials for certify its effects.

[Normal-tension glaucoma. Its diagnosis and treatment]. / Glaucomul cu presiune normala. Diagnostic si tratament.

The paper attempt a NPG definition in the light of the most recently data from literature. Modern investigation techniques (CDI, LDF, laser scan angiography) are summarized to support the presently most accepted pathogenic theory--the vascular theory. There are also reviewed the main clinical conditions to do differential diagnosis and main methods of its treatment.