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Expression of human MxA protein in mosquito cells interferes with LaCrosse virus replication.
Miura, T A; Carlson, J O; Beaty, B J; Bowen, R A; Olson, K E.
J Virol ; 75(6): 3001-3, 2001 Mar.
Article in English | MEDLINE | ID: mdl-11222725

ABSTRACT

Human MxA protein inhibits LaCrosse virus (LAC virus; family Bunyaviridae) replication in vertebrate cells and MxA-transgenic mice. LAC virus is transmitted to humans by Aedes triseriatus mosquitoes. In this report, we have shown that transfected mosquito cells expressing the human MxA cDNA are resistant to LAC virus but permissive for Sindbis virus (family Togaviridae) infection.


Subject(s)
Aedes/virology , Antiviral Agents/metabolism , GTP-Binding Proteins , La Crosse virus/physiology , Proteins/metabolism , Virus Replication/drug effects , Aedes/cytology , Aedes/genetics , Animals , Antiviral Agents/genetics , Cells, Cultured , Humans , Myxovirus Resistance Proteins , Proteins/genetics , Sindbis Virus/physiology , Transfection
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