Expanding the Scope of C-Glycoside Synthesis from Unstable Organolithium Reagents Using Flow Microreactors.

C-glycosides are versatile scaffolds for drugs and bioactive compounds. The common organolithium-based synthesis of C-glycosides is limited by low reaction temperatures and a restricted substrate scope. To address these issues, a flow microreactor (FMR) was utilized for rapid mixing and precise temperature control, enabling C-glycoside synthesis at temperatures up to 40 °C and expanding the substrate scope. Continuous C-glycoside synthesis was achieved with a throughput of 21.9 g h-1, demonstrating the industrial potential of FMRs.

Linked Rotaxane Structure Restricts Local Molecular Motions in Solution to Enhance Fluorescence Properties of Tetraphenylethylene.

The restriction of local molecular motions is critical for improving the fluorescence quantum yields (FQYs) and the photostability of fluorescent dyes. Herein, we report a supramolecular approach to enhance the performance of fluorescent dyes by incorporating a linked rotaxane structure with permethylated α-cyclodextrins. Tetraphenylethylene (TPE) derivatives generally exhibit low FQYs in solution due to the molecular motions in the excited state. We show that TPE with linked rotaxane structures on two sides displays up to 15-fold higher FQYs. Detailed investigations with variable temperature 1 H NMR, UV-Vis, and photoluminescence spectroscopy revealed that the linked rotaxane structure rigidifies the TPE moiety and thus suppresses the local molecular motions and non-radiative decay. Moreover, the linked rotaxane structure enhances the FQY of the dye in various solvents, including aqueous solutions, and improves the photostability through the inhibition of local molecular motions in the excited TPE.

Suppression of Undesirable Isomerization and Intermolecular Reactions of Double Bonds by a Linked Rotaxane Structure.

For luminescent materials, the isomerization and intermolecular reactions of their double bonds are often undesirable because they cause a reduction in the luminescence properties of the π-system. Herein, we report a new methodology to simultaneously prevent isomerization and intermolecular reactions by utilizing the steric effect of a linked rotaxane structure. The ring units are covalently linked in order to prevent any undesired shuttling effect from occurring during isomerization. In addition, the insulated structure provides robust optical properties by prevention of intermolecular reactions. Bulky linked rotaxane structures on both sides of the N=N and C=C double bonds suppress E/Z isomerization; photoluminescence quantum yield (PLQY) measurements reveal that this results in suppression of PLQY reduction caused by isomerization. Moreover, an improvement in the stability under light irradiation and air atmosphere is demonstrated.

Insulated conjugated bimetallopolymer with sigmoidal response by dual self-controlling system as a biomimetic material.

Biological systems are known to spontaneously adjust the functioning of neurotransmitters, ion channels, and the immune system, being promoted or regulated through allosteric effects or inhibitors, affording non-linear responses to external stimuli. Here we report that an insulated conjugated bimetallopolymer, in which Ru(II) and Pt(II) complexes are mutually connected with insulated conjugations, exhibits phosphorescence in response to CO gas. The net profile corresponds to a sigmoidal response with a dual self-controlling system, where drastic changes were exhibited at two threshold concentrations. The first threshold for activation of the system is triggered by the depolymerization of the non-radiative conjugated polymer to luminescent monomers, while the second one for regulation is triggered by the switch in the rate-determining step of the Ru complex. Such a molecular design with cooperative multiple transition metals would provide routes for the development of higher-ordered artificial molecular systems bearing bioinspired responses with autonomous modulation.

Synthesis and Acid-Responsiveness of an Insulated π-Conjugated Polymer Containing Spiropyrans in Its Backbone.

A π-conjugated polymer containing spiropyrans (SPs), which could be almost completely converted to protonated merocyanines (MCH⁺) and back to the SP form by adding an acid and a base, respectively, was developed. The insulation of the π-conjugated polymer, referred to as insulated spiropyran-containing poly(p-phenylene ethynylene) (ins-SP-PPE), using permethylated α-cyclodextrins (PM α-CD) suppressed the π-π interaction between the polymer chains containing MCH⁺, and the installation of PM α-CD improved the switching ability of SPs. The polymer exhibited repeatable acidochromism with almost complete conversion between the SP and MCH⁺ forms. Photoluminescence measurements were conducted and the acid-induced luminescence quenching of the polymer in the solution was observed, which stemmed from energy transfer from the PPE to MCH⁺ moieties. In the solid state, the quantum yield of ins-SP-PPE was more than twice that of the uninsulated polymer, which derived from the insulation effects. The acid-induced luminescence quenching was also observed in the solid state.