ABSTRACT
A 73-year-old man had undergone right hemicolectomy for advanced colon cancer in May 2006, and he concurrently had multiple liver metastases. After the operation, the patient was given chemotherapy with FOLFIRI. A partial response was achieved for twelve months, and then the liver tumors enlarged. Second-line chemotherapy with FOLFOX was delivered. After several months the liver tumors further enlarged and a new pulmonary lesion appeared with an increased serum CEA level. Therefore, chemotherapy with S-1 (120 mg/day) was started, with 2 weeks' administration followed by a one-week drug-free period. Several months later, the liver tumors and tumor makers decreased. S-1 is expected to be an effective agent for the treatment of advanced colon cancer with liver metastases after FOLFIRI and FOLFOX.
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Colonic Neoplasms/drug therapy , Liver Neoplasms/drug therapy , Oxonic Acid/therapeutic use , Salvage Therapy , Tegafur/therapeutic use , Aged , Biopsy , Camptothecin/analogs & derivatives , Camptothecin/therapeutic use , Carcinoembryonic Antigen/blood , Colonic Neoplasms/blood , Colonic Neoplasms/diagnostic imaging , Drug Combinations , Fluorouracil/therapeutic use , Humans , Leucovorin/therapeutic use , Liver Neoplasms/blood , Liver Neoplasms/diagnostic imaging , Liver Neoplasms/secondary , Male , Organoplatinum Compounds/therapeutic use , Oxonic Acid/administration & dosage , Tegafur/administration & dosage , Tomography, X-Ray ComputedABSTRACT
We present a case of a bronchogenic pulmonary cyst in a 48-year-old patient. We performed [corrected] mucoclasis using argon laser photocoagulation following resection of mucosa, closure of some drainage bronchus, and covering of the inner surface by the intrapulmonary bronchogenic cyst with an [corrected] absorbable vicryl mesh. At [corrected] 4-year [corrected] follow-up, the patient had no signs of recurrence.
Subject(s)
Bronchogenic Cyst/diagnosis , Bronchogenic Cyst/surgery , Laser Coagulation/methods , Lung Diseases/diagnosis , Lung Diseases/surgery , Pneumonectomy/methods , Bronchoscopy/methods , Combined Modality Therapy , Follow-Up Studies , Humans , Male , Middle Aged , Risk Assessment , Severity of Illness Index , Tomography, X-Ray Computed , Treatment OutcomeABSTRACT
OBJECTIVE: The purpose of this study was to describe the computed tomography (CT) and pathologic features of 5 nodules of pulmonary dirofilariasis in 4 patients. METHODS: Four patients with 5 nodules of pathologically confirmed pulmonary dirofilariasis who under went CT were enrolled, and the imaging interpretations were retrospectively compared with the histopathologic characteristics. RESULTS: Three of the 4 patients had a solitary nodule, and the remaining patient had 2 nodules. All the nodules were distributed in the right lower lobe and were attached to the pleura. They were all round or oval in shape and ranged in size from 11 to 22 mm in largest diameter (mean=17 mm). On thinner section CT, the nodules had a well-defined smooth margin with or without a shallow notch; they were connected to the arterial branch and, occasionally, to the venous branch. On contrast-enhanced CT, all the nodules contained a homogeneous low-attenuation area, which corresponded to areas of coagulative necrosis on histopathologic examination. CONCLUSION: Although the CT findings of a pulmonary dirofilariasis nodule are nonspecific, awareness of the findings on contrast-enhanced CT and the pathologic appearance of this rare benign condition may facilitate its differentiation from a malignant nodule.