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Bioorg Med Chem Lett
; 14(11): 2897-900, 2004 Jun 07.
Article
in English
| MEDLINE
| ID: mdl-15125955
ABSTRACT
Reverse hydroxamate-based selective TACE inhibitors are described. They have potent TACE inhibitory activities and excellent selectivities against MMP-1, 2, 3, 8, 9, 13, 14, and 17. One representative compound, 18 has demonstrated an excellent oral inhibitory activity of the lipopolysaccharide (LPS)-stimulated TNF-alpha production in rats.
