ABSTRACT
An 83-year-old man had been prescribed clopidogrel for pontine infarction since 8 months previously, and had had a cough for the last 2 weeks of this period. Laboratory examinations on admission showed a marked increase in eosinophils and elevated serum immunoglobulin E levels. Chest radiography showed bilateral ground-glass opacities, mild reticulation, and interlobar pleural effusion in the minor fissure. After clopidogrel was discontinued his symptoms resolved, and his laboratory tests showed normal results. Bronchoalveolar lavage also showed an increase in eosinophils, and transbronchial biopsy revealed infiltration of eosinophils in the subepithelium of the bronchial mucosa. On the basis of these findings, we diagnosed eosinophilic pneumonia induced by clopidogrel. Reports on cases of lung diseases caused by anti-platelet drugs are rare. To the best of our knowledge, this case is the first report on clopidogrel-induced eosinophilic pneumonia.
Subject(s)
Platelet Aggregation Inhibitors/adverse effects , Pulmonary Eosinophilia/chemically induced , Ticlopidine/analogs & derivatives , Aged, 80 and over , Clopidogrel , Humans , Male , Ticlopidine/adverse effectsABSTRACT
The patient was a 95-year-old-man admitted to the urological section of our hospital because of hematuria. Transurethral resection of the bladder tumor (TUR-Bt) was performed. This tumor was diagnosed pathologically as bladder cancer (transitional cell carcinoma Grade 3 pT1). After 8 months, local reccurence was seen and TUR-Bt was performed. (pTa). After 1 month, his chest radiograph and computed tomogram showed a mass shadow in the left upper lung field. Cystoscopy did not reveal a local reccurence. The patient's condition worsened, and he died of respiratory failure after about 1 month. At autopsy, pathologic studies of the lung tumor revealed transitional cell carcinoma, and local recurrence was not seen. We report a rare case of pulmonary metastases from superficial bladder cancer without local reccurence.
