[Morphometric parameters of hepatic lobule vessels in mice during the restorative period after leg injury].

The diameters of the hepatic lobule vessels (interlobular veins, central veins, interlobular arteries, intralobular sinusoidal capillaries, interlobular bile ducts) were been studied 3, 7 and 28 days after shin bones fracture in CBA mice (n=30). Most pronounced changes of morphometric parameters indicative of hemodynamic disturbances, were found 3 days after the trauma. The increase of the diameter of central, interlobulat veins and sinusoidal capillaries took place, together with the decrease of the diameter of interlobular arteries, which, probably, promoted the reduction of arterial blood supply. The tendency for normalization of the diameter of interlobular veins, arteries and bile ducts was detected 28 days after the start of an experiment. However, the diameter of the central veins and sinusoidal capillaries remained significantly higher than in control group. Thus, it was found that the leg bone fracture was accompanied by the changes of morphometric parameters of the hepatic lobule, mediated by the organ response to injury.

[Microcirculatory bed and epithelial reproduction in avian liver at different stages of ontogenesis following a single exposure to hyperthermic conditions].

The aim of the present work was to study the reactive changes in avian (chicken) hepatic microcirculatory bed and epithelium following a single exposure to hyperthermic conditions at different stages of ontogenesis. Application of morphometric methods resulted in a demonstration of a unidirectional response of hepatic acinus vascular bed in embryonic period and after hatching of the birds, as well as differently directed effects of the mechanisms of cellular reproduction. In both experimental groups, heat shock results in the destructive changes in hepatic epithelium.

[Structural bases for the minimization of function of the proximal epitheliocytes of the nephrons in a single acute overheating of the body]. / Strukturnye osnovy "minimizatsii funktsii" proksimal'nykh épiteliotsitov nefronov pri odnokratnom ostrom peregrevanii organizma.

Morphological bases of functional potentialities of nephrons were studied in the experiment with 115 two-month rats under conditions of general momentary hyperthermia. The size of renal corpuscles tends to diminish. It is found that damages occur mainly in epithelium of the proximal parts of nephrons with disturbances in the reabsorption apparatus. The lowered epithelium reabsorptivity is directed to provide survival of the cells and their further participation in reparative processes.

[Effect of thermal stress on the morphogenetic potencies of nephron epithelium]. / Vliianie teplovogo stressa na morfogeneticheskie potentsii épiteliia nefrona.

Experiments on 46 male rats aged 6 months have been carried out to study the effect of thermal stress on biological potencies of the nephron epithelium with the use of the F. M. Lazarenko's method for cultivating organs and tissues in the body. Acute hyperthermia was found to intensify the destruction of proximal parts and renal corpuscles, to activate and prolong the proliferative phase of the implantation growth. In the implants, the epithelium gives rise to the formation of lining layers, immersion growth bands and spongy structures. In the course of differentiation there form atypical renal corpuscles and epithelial tubules whose structure conforms to the proximal and distal parts, as well as to Henle's loop. Thermal stress initiates morphogenetic potencies of the nephron epithelium. The method of cultivation under consideration holds promise for elaborating objective criteria of the appraisal of the effect produced by extreme factors on biological properties of tissues.